Interactions between drugs and polyvinyl chloride infusion bags.

Abstract

12 kinds of injectable drugs were investigated for adsorption to polyvinyl chloride intravenous fluid bags. The solutions were assayed by spectrophotometry or high performance liquid chromatography (HPLC). Diazepam and prochlorperazine dimaleate in unbuffered aqueous solution, and diazepam, clomipramine HCl, promethazine HCl, prochlorperazine dimaleate, clorpromazine HCl and levomepromazine HCl and levomepromazine HCl in buffered solution (pH 7 .4) showed significant adsorption.In all drugs studied, adsorption increased with time while loss of the drugs were not related to initial concentration.Adsorption also increased in parallel with a rise in temperature. Loss of diazepam was unaffected by pH. On the other hand, the extent of loss was greater at higher pH levels in levomepromazine HCl, promethazine HCl and clomipramine HCl.