Interactions Between Electromagnetic Fields and Immune System: Possible Mechanism for Pain Control

Markov, Marko S.; Nindl, Gabi; Hazlewood, Carlton F.; Cuppen, J.J.M.

doi:10.1007/1-4020-4278-7_12

Cited by 23 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunological studies show that PEMF, even low-intensity PEMF, can interact with cells and tissues 2,4. For example, the effect of PEMF on the immune system in phagocytic cells alone has attracted attention because of the role that extremely-low frequency electromagnetic field (ELF-EMF) plays in decreasing the growth rate of bacteria 3.…”

Section: Introductionmentioning

confidence: 99%

Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages

Ross¹,

Harrison²

2013

JIR

View full text Add to dashboard Cite

In the treatment of bacterial infections, antibiotics have proven to be very effective, but the way in which antibiotics are dosed can create a lag time between the administration of the drug and its absorption at the site of insult. The time it takes an antibiotic to reach therapeutic levels can often be significantly increased if the vascular system is compromized. Bacteria can multiply pending the delivery of the drug, therefore, developing treatments that can inhibit the inflammatory response while waiting for antibiotics to take effect could help prevent medical conditions such as septic shock. The aim of this study was to examine the effect of a pulsed electromagnetic field on the production of inflammatory markers tumor necrosis factor (TNF), transcription factor nuclear factor kappa B (NFkB), and the expression of the A20 (tumor necrosis factor-alpha-induced protein 3), in an inflamed-cell model. Lipopolysaccharide-challenged cells were exposed to a pulsed electromagnetic field at various frequencies in order to determine which, if any, frequency would affect the TNF-NFkB-A20 inflammatory response pathway. Our study revealed that cells continuously exposed to a pulsed electromagnetic field at 5 Hz demonstrated significant changes in the downregulation of TNF-α and NFkB and also showed a trend in the down regulation of A20, as compared with controls. This treatment could be beneficial in modulating the immune response, in the presence of infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages

Ross¹,

Harrison²

2013

JIR

View full text Add to dashboard Cite

show abstract

“…Several authors (see Blank et al 1992;Goodman et al 1994;Blank et al 1995;Simkó and Mattsson 2004;Monselise et al 2003;De Bruyn and de Jager 1994;Mevissen et al 1998;Markov et al 2006;Cossarizza et al 1993;Cuppen and Vink 2004) discussing the effects initiated by various EMF signals have demonstrated the production of cytokines, increased immune parameters and stress effects and concluded that EMF causes stress at the cellular level and that this leads to production of cytokines and consequently biological response, including immune response. This has led Simkó and Mattson (2004) to formulate a hypothesis that proposes a mechanism for immune activation due to short term EMF exposure (see Fig.…”

Section: Introductionmentioning

confidence: 99%

Immune stimulation in fish and chicken through weak low frequency electromagnetic fields

Cuppen¹,

Wiegertjes

Lobee³

et al. 2007

Environmentalist

View full text Add to dashboard Cite

A hypothesis is proposed how Low Frequency Electromagnetic Field (LF EMF) exposure can stimulate an immune response, based on recent insights in immunology. We hypothesize that the Immunent EMF treatment induces mild stress to cells, which then produce cytokines that function as alarms or so called danger signals for the immune system. In this way EMF treatment takes the place of multiplying pathogens, and the damage these cause, in the triggering of an immune response. In a first series of experiments in vitro common carp head kidney-derived phagocytes were used to determine ROS production as a measure for immune activation. Exposure to LF EMF signals (200-5,000 Hz) at 5 lT or 1.5 mT led to 42 or 33% increase in immune activity, respectively, compared to negative control values. EMF could also additionally stimulate chemically pre-stimulated samples up to 18% (5 lT) or 22% (1.5 mT). Significance of increase in ROS production in the total series was: p < 0.0001. In a second series of experiments in vitro commercial goldfish were used. Groups of fish were housed under equal conditions in at least four control tanks and 8-16 EMF-exposed tanks. Exposure was done with a predominantly vertical field at field strengths (rms) between 0.15 and 50 lT. Without treatment mortality was about 50% after 18 days, while the treatment at 5 lT reduced it to 20% on average. At field strengths 0.15, 0.5, 1.5, 5, 15 and 50 lT an equally strong effect was found. Reducing the field strength to 0.05, 0.06, 0.01 and 0.003 lT showed a gradually decreasing effect, which only at 0.003 lT is no longer statistically significant. Finally, in vitro experiments were done with 560 commercial broiler chickens exposed to infection pressure from coccidiosis. EMF exposure at 6.5 lT reduced intestinal lesions by 40% and improved feed conversion by 8%.

show abstract

“…Benefits include low cost, ready availability, ease of localized application, few if any side effects, and indefinite shelf life Rubik (1997). Immunological studies show that MF, even low-intensity MF, can interact with cells and tissues (Blank and Goodman, 1997;Markov et al, 2006). The antiinflammatory and wound healing applications of MF are well known (Selvam et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of time-varied magnetic field on inflammatory response in macrophage cell line RAW 264.7

Ross¹,

Harrison²

2012

Electromagnetic Biology and Medicine

View full text Add to dashboard Cite

The aim of this feasibility study was to determine the effectiveness of a commercially manufactured magnetic field (MF) device as an adjunct to pharmaceuticals during acute phase inflammatory response. The goal was to determine if inflammatory response interleukins IL-1, IL-6, IL-10, and tumor necrosis factor-alpha (TNF-α) would be affected by a 30 Hz time-varying magnetic field (MF). RAW 264.7 macrophage-like cells were induced with Gram-negative bacteria lipopolysaccharide (LPS) to initiate an acute inflammatory reaction. Following lipopolysaccharide (LPS) treatment, both inflamed and control cells were exposed to MF for 1 h. After MF exposure, cytokines of interest were measured and compared with controls. Outcomes revealed that LPS challenged cells continuously exposed to a 30 Hz time-varying magnetic field for 1 h demonstrated significant changes compared with controls. From cytokine test it was determined that MF exposure significantly decreased levels of IL-6 and IL-10 compared to unexposed counterparts. TNF-α production was significantly affected when MF was applied to cells only, but not to inflamed cells. Results suggest that the biological effect of 1 h exposure to a 30 Hz time-varied magnetic field may act to down regulate specific cytokines in an inflamed environment.

show abstract

Interactions Between Electromagnetic Fields and Immune System: Possible Mechanism for Pain Control

Cited by 23 publications

References 6 publications

Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages

Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages

Immune stimulation in fish and chicken through weak low frequency electromagnetic fields

Effect of time-varied magnetic field on inflammatory response in macrophage cell line RAW 264.7

Contact Info

Product

Resources

About