2015
DOI: 10.1111/jphp.12453
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Interactions between histamine H1 receptor and its antagonists by using cell membrane chromatography method

Abstract: The studies showed CMC could be applied to investigate drug-receptor interactions.

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Cited by 10 publications
(6 citation statements)
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“…With the development of molecular biology, it is possible to construct cell lines with high expression of specific receptors, which makes the CMC method have stronger specificity and selectivity. Based on the development of CMC, a variety of CMC models such as L-type calcium channel, α 1A adrenergic receptor, histamine H 1 receptor and vascular endothelial growth factor receptor models are established in order to determine the K D values [75] , [76] , [77] , [78] .…”
Section: Affinity Chromatographymentioning
confidence: 99%
“…With the development of molecular biology, it is possible to construct cell lines with high expression of specific receptors, which makes the CMC method have stronger specificity and selectivity. Based on the development of CMC, a variety of CMC models such as L-type calcium channel, α 1A adrenergic receptor, histamine H 1 receptor and vascular endothelial growth factor receptor models are established in order to determine the K D values [75] , [76] , [77] , [78] .…”
Section: Affinity Chromatographymentioning
confidence: 99%
“…Finally, increase HCL solution (PH = 2, 150 μLÁmin −1 ) was used to remove the sample in the system. The SPR assay was conducted as described previously [26,27].…”
Section: Surface Plasmon Resonance (Spr) Analysismentioning
confidence: 99%
“…According to the previous work, frontal analysis of CMC could be used for direct determination of drug-receptor binding interactions by the following reversible equation [32,33]:…”
Section: Frontal Analysismentioning
confidence: 99%