Interactions between loaded drugs and surfactant molecules in micellar drug delivery systems: A critical review

Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media

“…Surfactants' ability to solubilize medicines in micellar form has been the focus of numerous studies. 1,32,[83][84][85][86][87][88][89] Several authors have examined the effects of polysorbates, ethoxylated alcohols, ethoxylated alkyl esters, alkyl sulphates, and alkyl trimethyl ammonium bromides (TABs) on the solubility of various drugs [90][91][92][93][94][95][96][97][98] and observed that the micellar solubilization capacity of a surfactant depends largely on its architecture. Hence, in the present study we have investigated the solubilising behaviour of two PEG based nonionic surfactants, Ge 48/16 and T1304 to check the solubility power of both the nonionic surfactants for the poorly water-soluble anticancer drug, QCT in the presence and absence of salt using HPLC technique.…”

Study on the association and phase separation behavior of surfactants and promethazine hydrochloride: impact of ammonium electrolytes

“…Numerous amphiphilic compounds have been extensively used in a variety of industries, including farming, food engineering, oil industry, environmental and biological areas, pharmaceutical technology, textiles, and metallurgy. 1–10 These molecules are composed of two parts: (i) a hydrophobic component that prefers oil to water and (ii) a hydrophilic component that prefers water to oil. Above their CMC, these amphiphilic compounds in an aqueous environment can form a molecular self-assembly, which is referred to as a micelle.…”