Interactions between occupational exposure to extremely low frequency magnetic fields and chemicals for brain tumour risk in the INTEROCC study

Turner, Michelle C.; Benke, Geza; Bowman, Joseph D.; Figuerola, Jordi; Fleming, Sarah; Hours, Martine; Kincl, Laurel; Krewski, Daniel; McLean, Dave; Parent, Marie‐Élise; Richardson, Lesley; Sadetzki, Siegal; Schlaefer, Klaus; Schlehofer, Brigitte; Schüz, Joachim; Siemiatycki, Jack; Tongeren, Martie van; Cardis, Elisabeth

doi:10.1136/oemed-2016-104080

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…Due in part to the widespread exposure of the general population to magnetic fields (MF) emitted by systems related to the generation, distribution and use of electricity, a debate has been going on for years focusing on the possibility that exposure to power frequency (50-60 Hz) fields could have adverse health effects, being those related to cancer development and/or promotion the most widely studied ones. Although the evidence of an association between chronic occupational exposure to these extremely low frequency (ELF) MF and the incidence of cancer is limited [1][2][3], the International Agency for Research on Cancer (IARC) of the World Health Organization, included this type of physical agent in its list of possible carcinogens, class 2B (IARC 2002 [4]), mainly on the basis of the epidemiological link between incidence of childhood leukaemia and residential exposure to MF [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Involvement of the EGF Receptor in MAPK Signaling Activation by a 50 Hz Magnetic Field in Human Neuroblastoma Cells

Martínez

Úbeda

Trillo

2019

Cell Physiol Biochem

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Section: Introductionmentioning

confidence: 99%

Involvement of the EGF Receptor in MAPK Signaling Activation by a 50 Hz Magnetic Field in Human Neuroblastoma Cells

Martínez

Úbeda

Trillo

2019

Cell Physiol Biochem

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“…A recent Canadian study found no evidence of an association between PM 2.5 or NO 2 and malignant brain tumors [ 23 ]. Turner et al [ 30 ] reported on malignant tumors of the brain, adjusted for a comprehensive array of personal and area-level confounders, and found no significant association with PM 2.5 , NO 2 or O 3 . When accounting for the different unit scales, the HRs in that study were very similar to those observed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…An ecological study from the US found volatile organic compounds to be associated with county-level incidence of tumors of the CNS [29]. Two studies of a cohort from the US found no association between a range of air pollutants (particulate matter with a diameter less than 2.5 μm (PM2.5) and 10 μm (PM 10 ), sulphur dioxide, nitrogen dioxide, carbon monoxide or ozone (O 3 )) and mortality from malignant tumors of the brain [30,31]. In an exploratory analysis of 54,304 members of the Danish Diet Cancer and Health cohort, mean outdoor residential NO x levels since 1971 were associated with an incidence rate ratio of 2.28 (95% confidence interval (CI): 1.25-4.19, cases = 95) per 100 μg/m 3 increase, for tumors of the brain and central nervous system [26].…”

Section: Introductionmentioning

confidence: 99%

Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark

et al. 2020

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Background: Inconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. Methods: We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10year mean residential outdoor exposure to particulate matter < 2.5 μm (PM 2.5), nitrous oxides (NO X), primary emitted black carbon (BC) and ozone. We used conditional logistic regression to calculate odds ratios (OR) linearly (per interquartile range (IQR)) and categorically. We accounted for personal income, employment, marital status, use of medication as well as socio-demographic conditions at area level. Results: Malignant tumors of the intracranial CNS was associated with BC (OR: 1.034, 95%CI: 1.005-1.065 per IQR. For NO x the OR per IQR was 1.026 (95%CI: 0.998-1.056). For malignant non-glioma tumors of the brain we found associations with PM 2.5 (OR: 1.267, 95%CI: 1.053-1.524 per IQR), BC (OR: 1.049, 95%CI: 0.996-1.106) and NO x (OR: 1.051, 95% CI: 0.996-1.110). Conclusion: Our results suggest that air pollution is associated with malignant intracranial CNS tumors and malignant non-glioma of the brain. However, additional studies are needed.

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“…The field of bioelectromagnetic research is still mainly focused on the initial exploration of biological effects. Accordingly, many countries are continuously studying the possible biological effects of various EMF sources and effective protection measures in addition to the application of EMF [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Long‐Term Exposure to L‐Band High‐Power Microwave on the Brain Function of Male Mice

Lin

Gao

Guo³

et al. 2021

BioMed Research International

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Currently, the impact of electromagnetic field (EMF) exposure on the nervous system is an increasingly arousing public concern. The present study was designed to explore the effects of continuous long-term exposure to L-band high-power microwave (L-HPM) on brain function and related mechanisms. Forty-eight male Institute of Cancer Research (ICR) mice were exposed to L-HPM at various power densities (0.5, 1.0, and 1.5 W/m2) and the brain function was examined at different time periods after exposure. The morphology of the brain was examined by hematoxylin-eosin (HE) and deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. Furthermore, cholinergic markers, oxidative stress markers, and the expression of c-fos were evaluated to identify a “potential” mechanism. The results showed that exposure to L-HPM at 1.5 W/m2 can cause generalized injuries in the hippocampus (CA1 and CA3) and cerebral cortex (the first somatosensory cortex) of mice, including cell apoptosis, cholinergic dysfunction, and oxidative damage. Moreover, the deleterious effects were closely related to the power density and exposure time, indicating that long-term and high-power density exposure may be detrimental to the nervous system.

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Interactions between occupational exposure to extremely low frequency magnetic fields and chemicals for brain tumour risk in the INTEROCC study

Abstract: There was no clear evidence for interactions between occupational ELF and chemical exposures in relation to glioma or meningioma risk observed. Further research with more refined estimates of occupational exposures is recommended.

Cited by 10 publications

References 39 publications

Involvement of the EGF Receptor in MAPK Signaling Activation by a 50 Hz Magnetic Field in Human Neuroblastoma Cells

Involvement of the EGF Receptor in MAPK Signaling Activation by a 50 Hz Magnetic Field in Human Neuroblastoma Cells

Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark

Effects of Long‐Term Exposure to L‐Band High‐Power Microwave on the Brain Function of Male Mice

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