Interactions between progesterone and tumor necrosis factor-α in the regulation of primordial follicle assembly

Nilsson, Eric; Stanfield, Jacob; Skinner, Michael K.

doi:10.1530/rep-06-0045

Cited by 56 publications

(54 citation statements)

References 42 publications

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“…While there is evidence that these proteins are present in the adult ovary (Cai & Stocco 2005, Peluso 2006, their expression in the developing mouse ovary has not been examined. In a recent study, PGRMC1 and PGRMC2 were detected in neonatal rat ovaries by microarray analysis and RT-PCR (Nilsson et al 2006).…”

Section: Hormonesmentioning

confidence: 98%

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Follicular assembly: mechanisms of action

Pepling¹

2012

Reproduction

211

190

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The differentiation of primordial germ cells (PGCs) into functional oocytes is important for the continuation of species. In mammals, PGCs begin to differentiate into oocytes during embryonic development. Oocytes develop in clusters called germ line cysts. During fetal or neonatal development, germ cell cysts break apart into single oocytes that become surrounded by pregranulosa cells to form primordial follicles. During the process of cyst breakdown, a subset of cells in each cyst undergoes cell death with only one-third of the initial number of oocytes surviving to form primordial follicles. The mechanisms that control cyst breakdown, oocyte survival, and follicle assembly are currently under investigation. This review describes the mechanisms that have been implicated in the control of primordial follicle formation, which include programmed cell death regulation, growth factor and other signaling pathways, regulation by transcription factors and hormones, meiotic progression, and changes in cell adhesion. Elucidation of mechanisms leading to formation of the primordial follicle pool will help research efforts in ovarian biology and improve treatments of female infertility, premature ovarian failure, and reproductive cancers.

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Section: Hormonesmentioning

confidence: 98%

“…However, a non-metabolizable version of progesterone, promegestone, also inhibited cyst breakdown and follicle assembly. A non-metabolizable progesterone analog blocked follicle formation in rat ovaries as well (Nilsson et al 2006). Like estrogen, there are several possible sources of progesterone.…”

Section: Hormonesmentioning

confidence: 99%

Follicular assembly: mechanisms of action

Pepling¹

2012

Reproduction

211

190

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“…In mouse and rat models, estradiol and progesterone have been shown to inhibit primordial follicle formation by inhibiting apoptosis [48,49] a process that could be reversed by pro-apototic TNFα [58,59]. The actions of estradiol and estrogenic EDCs (e.g., DES) may involve the inhibition of pro-apoptotic molecules, such as Fas ligand [60] leading to multioocyte follicles (MOFs) that in the long-term, do not progress to healthy ovulations [48].…”

Section: Introductionmentioning

confidence: 99%

Effects of Endocrine-disrupting Chemicals on Female Reproductive Health

Zama¹,

Bhurke²,

Uzumcu³

2016

TOBIOTJ

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Endocrine-disrupting chemicals (EDCs) are increasingly prevalent in the environment and the evidence demonstrates that they affect reproductive health, has been accumulating for the last few decades. In this review of recent literature, we present evidence of the effects of estrogen-mimicking EDCs on female reproductive health especially the ovaries and uteri. As representative EDCs, data from studies with a pharmaceutical estrogen, diethylstilbestrol (DES), an organochlorine pesticide methoxychlor (MXC), a phytoestrogen (genistein), and a chemical used in plastics, bisphenol a (BPA) have been presented. We also discuss the effects of a commonly found plasticizer in the environment, a phthalate (DEHP), even though it is not a typical estrogenic EDC. Collectively, these studies show that exposures during fetal and neonatal periods cause developmental reprogramming leading to adult reproductive disease. Puberty, estrous cyclicity, ovarian follicular development, and uterine functions are all affected by exposure to these EDCs. Evidence that epigenetic modifications are involved in the progression to adult disease is also presented.

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“…Observation indicate that P4 acts through the surface membrane progesterone receptors to regulate primordial follicle assembly, and that TNFα can override the inhibitory actions of P4 on follicle assembly. 12 The current study utilized a systems approach to detect all genes that are differentially expressed in response to seven different growth factor and hormone treatments known to influence (increase or decrease) primordial follicle assembly. One novel factor, basic fibroblast growth factor (FGF2), was experimentally determined to inhibit follicle assembly.…”

mentioning

confidence: 99%

“…bFGF was found to stimulate both theca cells and stromal cell growth. 12 Therefore, bFGF influence primordial follicle development.…”

mentioning

confidence: 99%

The Mechanism of Human Ovarian Primordial Follicular Assembly and Development

Sutandar

Santoso

2015

JKR

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ABSTRAKLatar Belakang: Pembentukan dan perkembangan folikel primordial merupakan aspek yang penting pada sistem reproduksi perempuan, tetapi mekanismenya masih kurang dipahami. Pembentukan folikel primordial adalah proses dimana folikel primordial ovarium terbentuk. Sebuah folikel primordial terdiri dari oosit yang berada di profase jika pembelahan meiosis yang pertama dan dikelilingi oleh satu lapisan sel-sel pra-granulosa. Proses ini secara langsung memengaruhi jumlah oosit yang tersedia bagi seorang wanita sepanjang usia reproduksinya. Kelainan pada perkembangan folikel primordial menyebabkan sejumlah patofisiologi, tetapi mekanisme terjadi masih belum dapat dipahami. Tujuan: Untuk memahami mekanisme perakitan dan pengembangan manusia ovarium folikel primordial. Metode: Review artikel Kesimpulan: Pembentukan folikel primordial adalah proses dimana folikel primordial ovarium terbentuk. Pembentukan folikel primordial dihambat oleh progesteron untuk tingkat yang lebih besar daripada estrogen, namun kedua steroid tersebut menghambat proses pembentukan. Proses apoptosis oosit secara acak dalam sarang oosit diperlukan untuk pembentukan folikel dan tumor necrosis factor-alpha (TNF) tampaknya juga terlibat dalam proses ini. Baru-baru ini, penelitian telah menunjukkan bahwa KL, basic fibroblast growth factor (bFGF), leukemia inhibitory factor (LIF), KGF, dan bone morphogenic protein -4 (BMP-4) dapat memengaruhi perkembangan folikel primordial.Kata kunci: folikel, primordial, pembentukan, perkembangan. ABSTRACTBackgrounds: primordial follicle assembly and development is a critical aspect of female reproduction, but poorly understood process on mechanistic level. Primordial follicle assembly is the process by which ovarian primordial follicles are formed. A primordial follicle is composed of an oocyte arrested in prophase if the first meiotic division and surrounded by a single layer of pre-granulosa cells. These processes directly affect the number of oocytes available to a female throughout her reproductive life. Abnormalities in primordial follicle development lead to a number of pathologies, but the mechanism are poorly understood. Objective: To understand the mechanism of assembly and development of human ovarian primordial follicle. Method: Literature review Conclusion: Primordial follicle assembly is the process by which ovarian primordial follicles are formed. Primordial follicle assembly was inhibited by progesterone to a greater degree than estrogen, but both steroids inhibited the assembly process. The apoptosis of random oocytes in the oocyte nests is required for primordial follicle assembly and tumor necrosis factor-alpha (TNFβ) appears to be involved in this process. More recently, studies have demonstrated that KL, basic fibroblast growth factor (bFGF), leukemia inhibitory factor (LIF), KGF, and bone morphogenic protein-4 (BMP-4) can influence primordial follicle development.

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Interactions between progesterone and tumor necrosis factor-α in the regulation of primordial follicle assembly

Cited by 56 publications

References 42 publications

Follicular assembly: mechanisms of action

Follicular assembly: mechanisms of action

Effects of Endocrine-disrupting Chemicals on Female Reproductive Health

The Mechanism of Human Ovarian Primordial Follicular Assembly and Development

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