Interactions between the immune system and the hypothalamo-pituitary-interrenal axis in fish

Weyts, F.A.A.; Cohen, Nicholas; Flik, G.; Kemenade, B.M.L. Verburg-van

doi:10.1006/fsim.1998.0170

Cited by 208 publications

(100 citation statements)

References 106 publications

(152 reference statements)

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“…For instance, the induced expression of mitochondrial chaperones of the heat shock protein 70 family (GRP75 or mortalin) was persistent in liver but not in head kidney after prolonged exposure to intermediate-high stock densities [39]. Despite this, we observed here that the head kidney expression of PRDX4-6 was significantly down-regulated by prolonged exposure to high-rearing densities, which might be indicative of the well known immunosuppressive effects of stressors related to rearing conditions [73,74], regardless of changes of feed intake in a pair-fed experimental model. In summary, six gilthead sea bream PRDX isoforms were unequivocally recognized as PRDX mammalian counterparts with a ubiquitous expression that was tissue-specific for each PRDX isoform.…”

Section: Discussioncontrasting

confidence: 51%

Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors

Pérez‐Sánchez

Bermejo-Nogales

Calduch-Giner

et al. 2011

Fish & Shellfish Immunology

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ABSTRACT. The aim of this work was to underline the physiological role of the antioxidant peroxiredoxin (PRDX) family in gilthead sea bream (Sparus aurata L.), a perciform fish extensively cultured in the Mediterranean area. First, extensive BLAST searches were done on the gilthead sea bream cDNA database of the AQUAMAX European Project (www.sigenae.org/iats), and six contigs were unequivocally identified as PRDX1-6 after sequence completion by RT-PCR. The phylogenetic analysis evidenced three major clades corresponding to PRDX1-4 (true 2-Cyst PRDX subclass), PRDX5 (atypical 2-Cys PRDX subclass) and PRDX6 (1-Cys PRDX subclass) that reflected the present hierarchy of vertebrates. However, the PRDX2 branch of modern fish including gilthead sea bream was related to the monophyletic PRDX1 node rather than to PRDX2 cluster of mammals and primitive fish, which probably denotes the acquisition of novel functions through vertebrate evolution. Transcriptional studies by means of quantitative real-time PCR evidenced a ubiquitous PRDX gene expression that was tissue-specific for each PRDX isoform. In a second set of transcriptional studies, liver and head kidney were chosen as target tissues in fish challenged with i) the intestinal parasite Enteromyxum leei, ii) a plant oil (VO) diet with deficiencies in essential fatty acids and iii) prolonged exposure to high rearing densities. These studies showed that PRDX genes were highly and mostly constitutively expressed in the liver and were not affected by dietary intervention or high density. In contrast, head kidney was highly sensitive to the different experimental challenges: significantly lower values were found for PRDX5 in the three trials, for PRDX6 in parasitized and high density fish and for PRDX1 in parasitized and VO fish. PRDX2, 3 and 5 were decreased only in VO, high density and parasitized animals, respectively. These findings would highlight the role of PRDXs as integrative and highly predictive biomarkers of health and welfare in fish and gilthead sea bream in particular.

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Section: Discussioncontrasting

confidence: 51%

Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors

Pérez‐Sánchez

Bermejo-Nogales

Calduch-Giner

et al. 2011

Fish & Shellfish Immunology

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“…Roulin 2004b; Griffith et al 2006). The fact that glucocorticoid suppression of immune function has been observed throughout various vertebrate taxa (McEwen et al 1997;Weyts et al 1999) provide a likely proximate link between eumelanin colouration and disease resistance which so far has received little attention. On an applied level, there are some potentially important implications of this trait correlation in fishes.…”

Section: Discussionmentioning

confidence: 99%

Melanin-based skin spots reflect stress responsiveness in salmonid fish

Kittilsen

Schjolden

Beitnes-Johansen

et al. 2009

Hormones and Behavior

134

122

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This version available http://nora.nerc.ac.uk/7671/ NERC has developed NORA to enable users to access research outputs wholly or partially funded by NERC. Copyright and other rights for material on this site are retained by the authors and/or other rights owners. Users should read the terms and conditions of use of this material at http://nora.nerc.ac.uk/policies.html#access This document is the author's final manuscript version of the journal article, incorporating any revisions agreed during the peer review process. Some differences between this and the publisher's version remain. You are advised to consult the publisher's version if you wish to cite from this article. www.elsevier.comContact CEH NORA team at nora@ceh.ac.ukThe NERC and CEH trade marks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. Wilson et al. 1994;Réale et al. 2007). Notwithstanding a certain lack of consensus in terminology, the evolution of these analogues of human personality has evoked considerable scientific interest. Among the questions raised are by which mechanisms behavioural syndromes are inherited, how the variation is maintained, which circumstances benefit different complex phenotypes, and what are the costs and benefits of limited plasticity imposed by more or less fixed trait associations (DeWitt et al. 1998;Koolhaas et al. 1999;Sih et al. 2004; Dingemanse and Réale 2005;McElreath et al. 2007;Réale et al. 2007;Wolf et al. 2007). Furthermore, in the barn owl (Tyto Alba) melanin-based colouration is associated with several behavioural, morphological and physiological characteristics that have been linked to stress coping ability (Almasi et al. 2008).Based on observations that HR and LR trout differed in melanin pigmentation our hypothesis was that spotted fish, in the closely related specie Atlantic salmon (Salmo Salar), 5 would show a lower cortisol reponse to stress when compared to a non-spotted group of individuals. Furthermore, several documented changes in the behaviour of the two trout lines made us predict that also behaviour would differ between groups of spotted and non-spotted fish. The main focus of this study was therefore to test the hypothesis that there exist an association between melanin-based pigmentation and hypothalamus-pituitary-interrenal (HPIaxis) reactivity in salmonid fish. Furthermore, we tested the prediction that behavioural differences are present in two groups of fish chosen divergently on melanin pigmentation. Materials and methods Quantification of melanin-based colorationIn the studies described below, photographs of experimental fish were captured with a Canon EOS 450D digital camera and transferred to a computer for further analyses of melanin-based coloration. Prior to photography, each fish were sedated in 200 mg/l MS-222 and placed adjacent to a measuring tape with millimetre resolution, allowing for an accurate estimation of the area where spots were counted. The d...

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“…Climate change is predicted to alter host-parasite relationships during this century, especially for example, thermal stress that leads to reduced immune-competency (Weyts et al 1999;76 Nikokelainen et al 2004) and enhanced consumption rates of prey that leads to increased 77 parasite exposure via intermediate hosts (Toscano et al 2014 The S. cephalus used in the experiment were all between 69 and 89 mm starting length (mean 118 80.8 ± 0.8 mm) and age 1+ years. They were sourced from an aquaculture site in Southern…”

mentioning

confidence: 99%

Interactions of warming and exposure affect susceptibility to parasite infection in a temperate fish species

2016

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Interactions between the immune system and the hypothalamo-pituitary-interrenal axis in fish

Cited by 208 publications

References 106 publications

Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors

Molecular characterization and expression analysis of six peroxiredoxin paralogous genes in gilthead sea bream (Sparus aurata): Insights from fish exposed to dietary, pathogen and confinement stressors

Melanin-based skin spots reflect stress responsiveness in salmonid fish

Interactions of warming and exposure affect susceptibility to parasite infection in a temperate fish species

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