Interactions du benzoate d'oestradiol et de la progesterone sur le development de l'oviducte de caille (Coturnix coturnix japonica)

Laugier, Christian; Brard, E; Sandoz, Daniel; Boisvieux‐Ulrich, Emmanuelle

doi:10.1016/0016-6480(75)90082-9

Cited by 21 publications

(15 citation statements)

References 14 publications

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“…Nous n'envisagerons ici que ce qui concerne l'6pith61ium luminal, l'ensemble de la diff6rencia-tion, et la formation des glandes 6tant d6j~ dEcrites (8,15) ou en pr6paration.…”

Section: Resultatsunclassified

“…Chez la poule en ponte la concentration plasmatique des cestrog~nes (eestradiol et oestrone) se situe entre 100 et 250 pg/ml, aiors que celle de la progesterone varie de 0.5 ~ 2 ng/ml (16). Les concentrations plasmatiques des cestrog6nes restent faibles et ne justifient pas les doses massives injectEes habituelle- 466 THE JOURNAL OF CELL BIOLOGY 9 VOLUME 71, 1976 ment (1-5 mg/jour) et qui stimulent beaucoup plus les ph6nom6nes s6cr6toires que la ciliogen~se (8,15). C'est pour cette raison que malgr6 les r6centes 6tudes ultrastructurales de l'action des oestrog~nes (6, 12) la ciliogen~se a 6t6 tr~s peu illustr6e dans le magnum des oiseaux.…”

Section: Discussionunclassified

“…I1 est connu que la progest6rone inhibe les divisions et stimule fortement les ph6no-m~nes s6cr6toires du magnum des oiseaux lorsqu'elle agit avec ou apr~s les cestrog~nes (10)(11)(12)8). Notre 6tude montre par ailleurs, l'importance fondamentale de la dose de benzoate d'0estradiol dans les traitements ~stro-progestatifs puisque avec 10 p,g/jour d'~estrog6ne, la progest6rone permet en 6 jours la mise en place d'un 6pith61ium comparable h celui d'une caille en ponte alors qu'en doublant la dose d'oestrog~ne, toutes les cellules de l'6pith61ium luminal deviennent s6cr6trices.…”

Section: Discussionunclassified

“…Aussi, avant de provoquer la transformation des cellules h mucus en cellules cili6es, nous avons cherch6 h contr61er, chez des cailles ovariectomis6es, la diff6renciation des cellules ~pith61iales soit en cellules cili6es, soit en cellules h mucus. La dose d'oestrog~ne inject6e nous parait &re tr~s critique, notamment dans les traitements oestroprogestatifs (8,3,15). De tr~s nombreux traitements ont 6t6 6tudi6s en faisant varier les doses, les dur6es, et le moment d'action des oestrog~nes et de la progest6rone.…”

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[Ciliogenesis in the mucous cells of the quail oviduct. II. Hormonal control]

Sandoz¹,

Biosvieux-Ulrich²,

Laugier³

et al. 1976

The Journal of Cell Biology

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The hormonal control of ciliogenesis and transformation of mucous cells was studied in the oviduct (magnum) of ovariectomized quails. Estradiol benzoate induces ciliogenesis with doses varying from 10 t~g/day to 100 txg/day after 6 days of treatment. With 100 txg/day, differentiation of some mucous cells is also induced as well as the formation of transitory "mixed cells" which are in the process of ciliogenesis and contain mucous granules.Associated with progesterone (1 mg/day), estradiol benzoate (10 txg/day) induces the differentiation of mucous cells and ciliated cells. The luminal epithelium of quails injected with this mixture is similar to the luminal epithelium observed in the oviduct of laying quails. With the same dose of progesterone (1 mg/day) and 20 ~g/day of estradiol benzoate for 6 days, ciliogenesis is completely inhibited. All epithelial cells are secretory cells.Transformation of 50% of the mucous cells into ciliated cells is obtained by following the previous estradiol-progesterone treatment with the injection of estradiol benzoate (20 /zg/day) for 3 days. Divisions of mucous cells were also observed. It is also possible to induce ciliogenesis in some mucous cells by withdrawing both hormones for 3 days. In this case, no cell divisions were observed.La ciliogen~se s'effectue spontan6ment dans les cellules ~ mucus de l'6pith61ium du magnum des cailles en ponte (article I), mais ce ph6nom~ne n'int6resse qu'une faible proportion des cellules. Dans le but de d6montrer la transformation de cellule h mucus en cellule cili6e, nous avons cherch6 ~ reproduire et ~ g6n6raliser ces transformations par des traitements hormonaux chez des cailles castr6es.Bien que le magnum des oiseaux soit un organe cible des hormones st6roides particuli~rement 6tu-di6, le contr61e hormonal de la ciliogen~se n'a pas 6t6 jusqu'ici clairement d6montr6. Aussi, avant de provoquer la transformation des cellules h mucus en cellules cili6es, nous avons cherch6 h contr61er, chez des cailles ovariectomis6es, la diff6renciation des cellules ~pith61iales soit en cellules cili6es, soit en cellules h mucus. La dose d'oestrog~ne inject6e 460

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“…Nous n'envisagerons ici que ce qui concerne l'6pith61ium luminal, l'ensemble de la diff6rencia-tion, et la formation des glandes 6tant d6j~ dEcrites (8,15) ou en pr6paration.…”

Section: Resultatsunclassified

Section: Discussionunclassified

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[Ciliogenesis in the mucous cells of the quail oviduct. II. Hormonal control]

Sandoz¹,

Biosvieux-Ulrich²,

Laugier³

et al. 1976

The Journal of Cell Biology

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“…Even when it can be induced by estrogen injections, such as in immature bird oviduct [3,44,45,68,70], all steps of ciliogenesis are found simultaneously in the same oviduct ( Fig. Even when it can be induced by estrogen injections, such as in immature bird oviduct [3,44,45,68,70], all steps of ciliogenesis are found simultaneously in the same oviduct ( Fig.…”

Section: Centriolooenesismentioning

confidence: 99%

Development and functions of the cytoskeleton during ciliogenesis in metazoa

Lemullois¹,

Boisvieux‐Ulrich²,

Lainé³

et al. 1988

Biology of the Cell

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The different steps of ciliogenesis occurring in quail oviduct were compared to the ciliogenesis pattern described in other metazoan species. Centrioles are generated according to pathways that are found within the same cell: the centriolar and the acentriolar pathways. In the acentriolar pathway, centrioles are generated in the Golgi area, without contact with the preexisting centrioles of the centrosomes, and they migrate toward the apical membrane. The control of this polarized migration was studied by means of several drugs (colchicine, nocodazol, taxol, cytochalasin D, benzodiazepines) and immunocytochemistry. It was suggested that an actin-myosin system was involved in the migration of centrioles, whereas labile microtubules were not necessary. Basal bodies must dock with plasma membrane or cytoplasmic vesicles for the initiation of axonemal microtubule polymerization. This signal is necessary even in the presence of taxol.

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