Interactive Effect of Cigarette Smoking With Human 8-Oxoguanine DNA N-Glycosylase 1 (hOGG1) Polymorphisms on the Risk of Lung Cancer: A Case-Control Study in Taiwan

Abstract

Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens. In this case-control study, the authors examined the interactive effect of hOGG1 gene polymorphisms and cigarette smoking on the risk of lung cancer in Taiwan. A total of 1,096 cases and 1,007 controls were enrolled from 6 medical centers in Taiwan during 2002-2004. hOGG1 Ser326Cys genetic polymorphisms were determined using the MassARRAY system (SEQUENOM, Inc., San Diego, California). Tobacco smoking history was obtained through personal interview according to a structured questionnaire. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals. The odds of developing lung cancer for persons with the Cys/Cys genotype versus the Ser/Ser genotype were 1.11 (95% confidence interval (CI): 0.74, 1.65) for never smokers, 1.45 (95% CI: 0.74, 2.83) for moderate smokers, and 3.52 (95% CI: 1.54, 8.06) for heavy smokers. The P value for interaction in the logistic model was 0.01. The increased risk associated with the Cys/Cys genotype among heavy smokers remained statistically significant for various histologic types of lung cancer, including adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. The authors conclude that there was a noticeable modifying effect on the association between hOGG1 genotype and lung cancer risk by cigarette smoking status.

Smoking, Green Tea Consumption, Genetic Polymorphisms in the Insulin-Like Growth Factors and Lung Cancer Risk

“…The mean age of our lung cancer patients at recruitment was 66.2 years was also comparable to that found in a previous study for Taiwanese (63.4 years) [35]. In addition, prevalence of cigarette smoking in our study subjects (cases, 54.1%; controls, 27.1%) was consistent with the findings of a previous study in Taiwanese (cases, 52.4%; controls, 29.9%) [36]. Therefore, our study subjects could be regarded to as representative of the general population of Taiwan.…”

hOGG1, p53 Genes, and Smoking Interactions are Associated with the Development of Lung Cancer

“…The risk of lung cancer among Henanese with Cys/Cys is 2.12 (1.03 -4.39) times high of that among Henanese with Ser/Ser or Ser/Cys genotype. Thess results are sinliar with the previous studies (Chang et al, 2009;Liu et al, 2010).…”

The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies

“…Previous studies demonstrated that genetic variation in OGG1 affects cancer susceptibility; the frequency of the OGG1 326Cys allele was found to be significantly higher in patients when compared with controls [22], [24], [25], [37], [38]; however, this association was not replicated by other studies [9], [13]–[17]. Overall, we did not found that individuals carrying the Cys/Cys genotype had significantly increased risk of lung cancer when compared with the Ser/Ser genotype, no significant association with lung cancer risk was found in dominant model, recessive model and heterozygous co-dominant model (Ser/Cys vs. Cys/Cys).…”