Interactive Effects of the COMT Gene and Training on Individual Differences in Supervisory Control of Unmanned Vehicles

Parasuraman, Raja; Kidwell, Brian; Olmstead, Ryan; Lin, Mingkuan; Jankord, Ryan; Greenwood, Pamela M.

doi:10.1177/0018720813510736

Cited by 11 publications

(7 citation statements)

References 62 publications

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“…COMT is an enzyme that catalyzes the transfer of a methyl froug from S-adenosymethionine to catecholamines, including the neurptransmitters dopamine, epinephrine, and norepinephrine [30]. Many studies have demonstrated that genetic polymorphism of the important estrogen-metabolizing enzyme COMT increased the risk of BC [31,32].…”

Section: Discussionmentioning

confidence: 99%

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis

Wang¹,

Yin

et al. 2018

Gynecol Obstet Invest

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Background: This study aimed to investigate the action mechanism of β-estradiol in MCF-7 breast cancer (BC) cells. Methods: The cell samples were sequenced using Hiseq 2000, including 2 MCF-7 controls and 2 samples treated with β-estradiol. Differentially expressed genes (DEGs) were screened using the NOISeq package in R, followed by the functions and pathways analyses using Database for Annotation, Visualization and Integrated Discovery. DEGs associated with β-estradiol were selected using the WbeGestalt software, and the corresponding target miRNAs of these genes were analyzed from different miRNA databases. Additionally, protein-protein interaction network of the drug-associated genes was constructed using Cytoscape. Results: A total of 1,835 DEGs in BC samples were screened. Thereinto, DEGs associated with BC (17 upregulated and 28 downregulated DEGs) were involved in the regulation of cell proliferation, response to endogenous stimulus, and response to hormone stimulus, while the genes participated in several significant pathways. Cyclin D1, estrogen receptor 1, catechol-O-methyltransferase, and cathepsin D (CTSD; hub genes) were the predicted new genes associated with β-estradiol. Besides, hsa-miR-140-3p was the only target miRNA of CTSD. Conclusion: β-Estradiol may play a key role in contributing to BC progression and metastasis by regulating the expression of the selected genes.

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Section: Discussionmentioning

confidence: 99%

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis

Wang¹,

Yin

et al. 2018

Gynecol Obstet Invest

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“…Neuro-ergonomic approaches in Nelson et al (2014) improved vigilance task performance via transcranial direct current stimulation. Parasuraman et al (2014) identified a genotype associated with higher skill acquisition for executive function and supervisory control. Sarter and Woods (1993, p. 118) advised directions to support awareness through 'new approaches to training human supervisory controllers' , and Gopher (1991) suggested potential promise via the enhancement of 'skill at the control of attention' .…”

Section: Solution Area (4): Support the Role From The Behaviourism Pamentioning

confidence: 99%

How to keep drivers engaged while supervising driving automation? A literature survey and categorisation of six solution areas

Cabrall

Eriksson

Dreger

et al. 2019

Theoretical Issues in Ergonomics Science

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This work aimed to organise recommendations for keeping people engaged during human supervision of driving automation, encouraging a safe and acceptable introduction of automated driving systems. First, heuristic knowledge of human factors, ergonomics, and psychological theory was used to propose solution areas to human supervisory control problems of sustained attention. Driving and non-driving research examples were drawn to substantiate the solution areas. Automotive manufacturers might (1) avoid this supervisory role altogether, (2) reduce it in objective ways or (3) alter its subjective experiences, (4) utilize conditioning learning principles such as with gamification and/or selection/ training techniques, (5) support internal driver cognitive processes and mental models and/or (6) leverage externally situated information regarding relations between the driver, the driving task, and the driving environment. Second, a cross-domain literature survey of influential human-automation interaction research was conducted for how to keep engagement/attention in supervisory control. The solution areas (via numeric theme codes) were found to be reliably applied from independent rater categorisations of research recommendations. Areas (5) and (6) were addressed by around 70% or more of the studies, areas (2) and (4) in around 50% of the studies, and areas (3) and (1) in less than around 20% and 5%, respectively. The present contribution offers a guiding organisational framework towards improving human attention while supervising driving automation. Relevance to human factors/Relevance to ergonomics theory A good amount of human factors research has already previously been devoted to examining human vigilance in supervising automated process (both by experimental investigation and literature review synthesis). However, given recent advances and accidents with humans ARTICLE HISTORY

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“…At the same time, some studies emphasize the relationship of the Met allele of the BDNF and COMT genes with a high level of attention switching during problem solving, multitasking [22], and higher executive functions [23][24][25].…”

Section: Genetic Factors Associated With Other Cognitive Emotional Pmentioning

confidence: 99%

A review of current research on genetic factors associated with the functioning of the perceptual and emotional systems of the brain

et al. 2019

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This article is a review of modern research on the relationship of genes of neurotransmitter, hormonal and neurotrophic systems of the brain with the work of perceptual and emotional systems of a person. The role of the BDNF, COMT, DRD2, HTR2A and other genes in the processes of visual recognition of words, virtual navigation, social perception, as well as in the implementation of other cognitive, emotional processes and executive functions, is discussed. The prospects of using the accumulated scientific data to study the characteristics of the visual perception of emotionally charged Internet-content with various informational orientations are discussed.

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Interactive Effects of the COMT Gene and Training on Individual Differences in Supervisory Control of Unmanned Vehicles

Abstract: Potential applications of this research include the development of individualized training methods for operators of multi-UV systems and selecting personnel for complex supervisory control tasks.

Cited by 11 publications

References 62 publications

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis

How to keep drivers engaged while supervising driving automation? A literature survey and categorisation of six solution areas

A review of current research on genetic factors associated with the functioning of the perceptual and emotional systems of the brain

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