In this paper the three-dimensional design of animation which is based on computer software is studied. The method that is used to design the animation is introduced. Through the three-dimensional design of animation, the designers can use software like 3D-Max to animate the model and to exhibit the design idea. With the construction of geometric model of stereo by the means of computer, the designers can found the model with dramatic color and texture; then can set up the model of movement and camera light. After the final rendering, which can generate a series of play, the animation of three-dimensional design can be real time continuous image. And finally realization of the computer simulation of the scene and the real object in space is accomplished. At the end of the paper, a example is made by the design software that shows the design process and effect of the three-dimensional design. The conclusion of this research is that the application of three dimension design is efficient to design the animation.