Interactive magnetic resonance imaging for paediatric vesicoureteric reflux (VUR)

Arthurs, Owen J.; Edwards, Andrea; Joubert, Ilse; Graves, Martin J.; Set, P. A. K.; Lomas, David J.

doi:10.1016/j.ejrad.2012.10.024

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…blueberry pineapple juice) have been investigated as oral contrast agents. [51][52][53][54][55][56] The following Table 4 summarizes the OCAs that are currently available for clinical application. These are not widely used.…”

Section: 12mentioning

confidence: 99%

Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

et al. 2018

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Tens of millions of contrast enhanced magnetic resonance imaging (MRI) exams are performed annually around the world. The contrast agents, which improve diagnostic accuracy, are almost exclusively small, hydrophilic gadolinium(III) based chelates. In recent years concerns have arisen surrounding the long term safety of these compounds, and this has spurred research into alternatives. There has also been a push to develop new molecularly targeted contrast agents or agents that can sense pathological changes in the local environment. This comprehensive review describes the state of the art of clinically approved contrast agents, their mechanism of action, and factors influencing their safety. From there we describe different mechanisms of generating MR image contrast such as relaxation, chemical exchange saturation transfer, and direct detection and the types of molecules that are effective for these purposes. Next we describe efforts to make safer contrast agents either by increasing relaxivity, increasing resistance to metal ion release, or by moving to gadolinium(III)-free alternatives. Finally we survey approaches to make contrast agents more specific for pathology either by direct biochemical targeting or by the design of responsive or activatable contrast agents.

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Section: 12mentioning

confidence: 99%

Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

et al. 2018

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“…7 Interactive MRI for VUR (iMRVC) shows promise, providing results comparable to MCUG. 25 The benefits of MRI and the lack of radiation remain offset by the sedation needed for the lengthy examinations, the cost of the procedure and lack of access to the study by the vast majority of patients undergoing investigation for UTI.…”

Section: Mrimentioning

confidence: 99%

A case-based approach to UTI imaging – making sense of the guidelines

et al. 2015

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Urinary tract infections (UTIs) are common amongst children and invariably result in imaging tests to look for correctable causes that may predispose the child to infection. The objective of imaging is to identify those children at risk of long-term renal damage. The ideal imaging algorithm is extensively debated in the literature owing to the lack of evidence-based data, evolving theories on the pathophysiology of UTI and vesicoureteric reflux (VUR). The present article provides a case-based approach to the imaging of UTIs and proposes guidelines relevant to the South African setting.

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MR of the Urogenital Tract in Children

Grattan‐Smith

Jones

2018

Pediatric Urogenital Radiology

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Interactive magnetic resonance imaging for paediatric vesicoureteric reflux (VUR)

Cited by 7 publications

References 25 publications

Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers

A case-based approach to UTI imaging – making sense of the guidelines

MR of the Urogenital Tract in Children

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