Intercalation into the DNA double helix and in vivo biological activity of water-soluble planar [Pt(diimine)(N,N-dihydroxyethyl-N′-benzoylthioureato)]+Cl− complexes: A study of their thermal stability, their CD spectra and their gel mobility

Synthesis, structure and interactions with DNA of novel tetranuclear, [Mn4(II/II/II/IV)] mixed valence complexes

“…Relaxation of negatively supercoiled plasmid is observed until comigration of the two forms occurs. Similar results have been reported previously [76,77].…”

DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

“…A compound's fluorescence excitation wavelength may also shift upon interaction with DNA [7]. Furthermore, changes in the circular dichroic spectrum of DNA in the presence and absence of varying ratios of drug:DNA can also indicate an interaction with DNA [10,11].…”

Polyaniline–DNA based sensor for the detection of anthracycline drugs

“…The potential was measured when its shift did not exceed 0.1 mV min -1 . 6 ] at the potential equal to a half sum of the peak potentials of ferricyanide ion with the amplitude of the applied sine potential of 5 mV within the frequency from 100 kHz to 0.04 Hz with a sampling rate of 12 points per decade. The calculations of capacitance and the charge transfer resistance from EIS spectra were made using NOVA software (Metrohm Autolab) by fitting procedure using the Randles equivalent circuit (2).…”

“…red shift of the DNA bands in UV-vis spectra [5], changes in circular dichroism of the complexes [6], or excitation of fluorescence of some indicators (ethidium bromide [7]). Being universal, optical methods are less appropriate for sensor mode and excessively sensitive to matrix interferences affecting the response of target interactions.…”