Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis

Abstract

Background/Aims: The aim of this study was to investigate the possibility that the K469E and G241R polymorphisms in the intercellular adhesion molecule-1 (ICAM-1) gene and the C-634G polymorphism in the interleukin (IL)-6 gene are associated with endometriosis in the Korean population. Methods: The ICAM-1 gene K469E and G241R polymorphisms and the IL-6 gene C-634G polymorphism were evaluated in 390 patients with endometriosis and 351 controls by polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The ICAM-1 gene G241R polymorphism was not observed in all subjects. No differences were observed in the ICAM-1 K469E and IL-6 C-634G genotype distributions and allele frequencies between patients with endometriosis and controls. In subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometriomas, no significant differences were observed in the ICAM-1 gene K469E or the IL-6 gene C-634G polymorphism frequencies between the subgroups and the controls. The combined analysis of the ICAM-1 gene K469E polymorphism and the IL-6 gene C-634G polymorphism did not show any additional significant findings. Conclusions: The K469E and G241R polymorphisms in the ICAM-1 gene and the C-634G polymorphism in the IL-6 gene may not be genetic factors related to susceptibility to advanced-stage endometriosis in the Korean population.

Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis

“…For further analysis, 54 full text articles were obtained. After thorough evaluation, 17 studies were found to be repeated in the database (Hsieh et al., ; Wieser et al., , ; Asghar et al., ; Teramoto et al., ; Bhanoori et al., ; Kitawaki et al., ; Zhao et al., ; Chae et al., ; Lee et al., ; Lu et al., ; Hank Juo et al., ; Chae et al., ; Vijaya Lakshmi et al., ; Mao et al., , ), 10 did not provide the raw data of TNF‐α/IL‐6 polymorphism that we needed for statistical analysis, and these studies reported specificity and sensitivity without the exact counts (Teramoto et al., ; Luo & He, ; Zhang et al., ; Chae et al., ; Lu et al., ; Zhang et al., ; Hank Juo et al., ; Zhou et al., ; Zhao et al., ; Kim et al., ), six studies were excluded because of duplication of data (Luo et al., , b; ; Zhou et al., , b; Mao et al., ), one was not a study of the human (Zhen et al., ), and three studies were on Caucasians (Wieser et al., , ; Zhao et al., ). Finally, 17 studies were selected (Hsieh et al., ; Lee et al., ; Asghar et al., ; Bhanoori et al., ; Kitawaki et al., ; Luo et al., ; Wang et al., ; Lee et al., ; Chae et al., ; Che et al., , b; Vijaya Lakshmi et al., ; Zeng et al., ; Mao et al., ; Zeng & Huang, ; Mao et al., ) (Fig.…”

“…Thus, the TNF‐α ‐308A/G polymorphism might not be a useful prognostic biomarker for endometriosis, especially in the Asian population. For the IL‐6 ‐634C/G genotype, no association was found with endometriosis in Asians and the results are supported by Chae et al (), who also found no association of the ‐634C/G gene polymorphism with endometriosis, or with any clinical subgroup of endometriosis. The subgroup of endometriosis stages III–IV cases was considered under the condition that one study (Chae et al., ) selected endometriosis stages III and IV as cases.…”

“…A G to A substitution at position ‐238 (D'Alfonso & Richiardi ), a G to A substitution at position ‐308 (Wilson et al., ), and a C to T substitution at position ‐1031 (Higuchi et al., ) are in the proximal promoter of the TNF‐α gene, and have already been examined for an association with endometriosis in previous studies. Also, some authors (Kitawaki et al., ; Wang et al., ; Chae et al., ) have suggested that the levels of IL‐6 in the blood and peritoneal fluid of women with stages III–IV endometriosis are markedly increased. According to these controversial results, it is still unclear whether these polymorphisms in the TNF‐α gene could affect the expression of the gene and could be related to the development of endometriosis.…”

“…Within the IL‐6 promoter region, some alleged single nucleotide polymorphisms (SNPs) are G‐597A , G‐572C , C‐634G , and G‐174C (Chae et al., ). Recently, several studies focused on the association between these polymorphisms in the IL‐6 gene and endometriosis (Lee et al., ; Wieser et al., ; Bhanoori et al., ; Chae et al., ), especially the G‐174C polymorphism and the C‐634G polymorphism (rs1800796, previously denoted as ‐572G/C ) (Wang et al., ). In different populations, an inconsistent correlation between these polymorphisms and endometriosis has been reported.…”

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss

“…Following the general definition, we classified patients into different groups according to the heterozygous or homozygous of IL-6 -576 (CC/GG/CG) (Oana et al 2014). Similarly, the ICAM-1 phenotypes were also defined as KK/ EE/KE according to the heterozygotes or homozygotes as described by others (Chae et al 2010;Liou et al 2015).…”