Intercellular Adhesion Molecule 1 Gene Polymorphisms in Graves’ Disease

Krętowski, Adam; Wawrusiewicz, Natalia; Mirończuk, Katarzyna; Myśliwiec, Janusz; Krętowska, Małgorzata; Kinalska, I

doi:10.1210/jc.2003-030131

Cited by 38 publications

(33 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The associations between age at onset and different human leukocyte antigen genotypes [28,29] and ICAM-1 gene alleles [30] have been reported. The criteria we used to stratify the patients into those with early and later ages of onset of disease were based on the epidemiological observations of the highest risk of the onset of GD [2].…”

Section: Discussionmentioning

confidence: 99%

A C/T Polymorphism in the 5' Untranslated Region of the CD40 Gene Is Associated with Later Onset of Graves' Disease in Japanese

et al. 2005

View full text Add to dashboard Cite

Abstract. Graves' disease (GD) is an autoimmune disorder with genetic predisposition. CD40, which stimulates lymphocyte proliferation and differentiation, is an important immunomodulator and is expressed in the thyroid follicular cells as well as antigen-presenting cells. A single nucleotide polymorphism (SNP) at position -1 of the Kozak sequence of the CD40 gene has been reported to be associated with the development of GD. The aim of the present study was to investigate whether CD40 gene polymorphism confers susceptibility to GD in Japanese. CD40 gene polymorphisms were studied in Japanese GD patients (n = 324) and healthy control subjects without anti-thyroid autoantibodies or a family history of autoimmune disorders (n = 229). A C/T polymorphism at position -1 of the CD40 gene was measured using the polymerase chain reaction restriction fragment length polymorphism. There was no significant difference in allele or genotype frequency of the CD40 SNP between GD and control subjects. There was a significant decrease in the TT genotype frequency in the GD patients, who developed GD after 40 years old, than those under 40 year of age. These data suggest that the SNP of CD40 gene is associated with susceptibility to later onset of GD in Japanese.

show abstract

Section: Discussionmentioning

confidence: 99%

A C/T Polymorphism in the 5' Untranslated Region of the CD40 Gene Is Associated with Later Onset of Graves' Disease in Japanese

et al. 2005

View full text Add to dashboard Cite

show abstract

“…ICAM1 is constitutively expressed in cells involved in immune response and induced on other cells, including endothelial and epithelial cells. It has a wellknown role in inflammation-related processes and immune surveillance, and derangements of its expression have been implicated in the development of a variety of inflammatory diseases (23)(24)(25) as well as in tumor progression of several cancers, including breast cancer (26 -28). ICAM1 is also involved in transmembrane signal transduction after binding to ␤2 integrin ligands and multimer formation (29), activating the mitogen-activated protein kinase pathway (30) and eventually transcription factors like AP-1 that regulate cell proliferation events (31).…”

Section: Discussionmentioning

confidence: 99%

Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus

et al. 2004

View full text Add to dashboard Cite

We conducted a large-scale association study to identify genes that influence nonfamilial breast cancer risk using a collection of German cases and matched controls and >25,000 single nucleotide polymorphisms located within 16,000 genes. One of the candidate loci identified was located on chromosome 19p13.2 [odds ratio (OR) ‫؍‬ 1.5, P ‫؍‬ 0.001]. The effect was substantially stronger in the subset of cases with reported family history of breast cancer (OR ‫؍‬ 3.4, P ‫؍‬ 0.001). The finding was subsequently replicated in two independent collections (combined OR ‫؍‬ 1.4, P < 0.001) and was also associated with predisposition to prostate cancer in an independent sample set of prostate cancer cases and matched controls (OR ‫؍‬ 1.4, P ‫؍‬ 0.002). High-density single nucleotide polymorphism mapping showed that the extent of association spans 20 kb and includes the intercellular adhesion molecule genes ICAM1, ICAM4, and ICAM5. Although genetic variants in ICAM5 showed the strongest association with disease status, ICAM1 is expressed at highest levels in normal and tumor breast tissue. A variant in ICAM5 was also associated with disease progression and prognosis. Because ICAMs are suitable targets for antibodies and small molecules, these findings may not only provide diagnostic and prognostic markers but also new therapeutic opportunities in breast and prostate cancer.

show abstract

“…In our previous study serum L-selectin and Intercellular Adhesion Molecule-1 (ICAM-1) were found to be elevated in patients with active GO, suggesting enhanced T cell recruitment [10]. Moreover the ICAM-1 gene polymorphism could influence the intensity and duration of the autoimmunity process and the infiltration of orbital tissues [11].…”

Section: Introductionmentioning

confidence: 97%

Increased percentage of L-selectin+ and ICAM-1+ peripheral blood CD4+/CD8+ T cells in active Graves' ophthalmopathy.

Pawłowski

Myśliwiec²,

Stasiak-Barmuta³

et al. 2009

Folia Histochem Cytobiol.

Self Cite

View full text Add to dashboard Cite

Abstract:The purpose of the study was to evaluate the percentage of CD4 + /CD8 + peripheral T cells expressing CD62L + and CD54 + in patients with Graves' disease and to assess if these estimations could be helpful as markers of active ophthalmopathy. The study was carried out in 25 patients with Graves' disease (GD) divided into 3 groups: 1/ 8 patients with active Graves' ophthalmopathy (GO) (CAS 3-6, GO complaints ≤1 year), 2/ 9 patients with hyperthyroid GD without symptoms of ophthalmopathy (GDtox) and 3/ 8 patients with euthyroid GD with no GO symptoms (GDeu). The control group consisted of 15 healthy volunteers age and sex matched to groups 1-3. The expression of lymphocyte adhesion molecules was evaluated by using three-color flow cytometry. In GO group the percentage of CD8 +CD54+ , CD8 +CD62L+ , CD4 +CD54+ and CD4 +CD62L+ T cells was significantly higher as compared to controls (p<0.001, p<0.05, p<0.01, p<0.001 respectively). In addition, the percentage of CD8 +CD54+ T lymphocytes was elevated in GO group in comparison to hyperthyroid GD patients (p< 0.05). CD4 +CD62L+ and CD8 +CD54+ percentages were also increased in GDtox and GDeu as compared to controls. We found a positive correlation between the TSHRab concentration and the percentage of CD8 +CD62L+ T cells in all studied groups (r= 0.39, p<0.05) and between the TSHRab level and CAS (r= 0.77, p<0.05). The increased percentage of CD8 +CD54+ and CD8 +CD62L+ T cells in patients with Graves' ophthalmopathy may be used as a marker of active orbital inflammation.

show abstract

Intercellular Adhesion Molecule 1 Gene Polymorphisms in Graves’ Disease

Cited by 38 publications

References 53 publications

A C/T Polymorphism in the 5' Untranslated Region of the CD40 Gene Is Associated with Later Onset of Graves' Disease in Japanese

A C/T Polymorphism in the 5' Untranslated Region of the CD40 Gene Is Associated with Later Onset of Graves' Disease in Japanese

Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus

Increased percentage of L-selectin+ and ICAM-1+ peripheral blood CD4+/CD8+ T cells in active Graves' ophthalmopathy.

Contact Info

Product

Resources

About