Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children. Do they play a role in the progression of atherosclerosis?

Fotis, Lampros; Giannakopoulos, D.; Stamogiannou, Lela; Xatzipsalti, Maria

doi:10.14310/horm.2002.1340

Cited by 38 publications

(40 citation statements)

References 65 publications

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“…To clarify these results a primary role of increased hepatic synthesis of HDL in alternate diet regimen and a better adaptation of liver metabolism to plasma lipid overload as compared to continuous cholesterol administration can be reasonably sustained [42]. Regarding systemic inflammatory state and endothelial activation no significant changes among groups were evidenced in any of measured markers, in contrast with other reports [40] [43]- [45]. This outcome can be attributed to the shorttime diet duration and the very early stage of coronary atherogenesis process documented by histology.…”

Section: Circulatory Lipid/lipoproteins and Inflammatory Markersmentioning

confidence: 83%

HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine

Vozzi¹,

Pelosi²,

Puntoni³

et al. 2014

OJMIP

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Section: Circulatory Lipid/lipoproteins and Inflammatory Markersmentioning

confidence: 83%

HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine

Vozzi¹,

Pelosi²,

Puntoni³

et al. 2014

OJMIP

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“…Moreover, the plasma levels of ICAM-1 shows parallelism with the significance of inflammation in diseases and it is elevated in various diseases such as infectious, inflammatory and neoplastic (Li et al, 1999;Hajilooi et al, 2004;Huang et al;Miller et al, 2007;Fotis et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The expression of ICAM-1 was detected in the endothelial cells in various inflammatory cases especially in infectious diseases both in vivo and in vitro studies (Reiss et al, 1998;Deeths & Mescher, 1999;Fotis et al;Hajilooi et al;).…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in the Expression of ICAM-1 in the Aorta of Wistar Albino Rats

et al. 2016

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KETANI, S.; KARAKOÇ, Z.; KETANI, M. A. & KILINÇ, M.Age-related changes in the expression of ICAM-1 in the aorta of Wistar albino rats. Int. J. Morphol., 34(4):1482Morphol., 34(4): -1486Morphol., 34(4): , 2016. SUMMARY:ICAM-1 which is expressed by endothelial cells and leukocytes are observed as first markers in diseases such as transplant rejection, diabetes and atherosclerosis and in infections caused by various pathogens. In the present study, it is aimed to reveal the age-related changes in the expression of ICAM-1 on rats. Therefore, a total of 30 albino rats were taken at the age of 6, 18 and 24 months without gender discrimination. Rats were fed with standard pellet feed during the study. Afterwards, rats were sacrificed and tissue samples were collected from their rats, and the samples were evaluated under the light microscope by staining with immnunohistochemical method. It was determined that the expression of both aortic endothelial cells and endothelial cells in the media layer had been significantly increased based on the age.

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“…With the accumulation of lipoproteins within the arterial subendothelium, a critical multi-process step ensues including the recruitment of monocytes, which trigger the activation of endothelial cells and the subsequent induction of pro-inflammatory genes including those coding for adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) (Fotis et al, 2012). It has been established that one of the key transcriptional regulators, NF-κB and its downstream signaling pathway, may play an important role in high glucose-induced endothelial dysfunction (Chen et al, 2009;Li et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

RXR agonists inhibit high glucose-induced upregulation of inflammation by suppressing activation of the NADPH oxidase-nuclear factor-κB pathway in human endothelial cells

Ning¹,

Zhu²,

Chai³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. An inflammatory response induced by high glucose is a cause of endothelial dysfunction in diabetes and is an important contributing link to atherosclerosis. Diabetes is an independent risk factor of atherosclerosis and activation of retinoid X receptor (RXR) has been shown to exert anti-atherogenic effects. In the present study, we examined the effects of the RXR ligands 9-cis-retinoic acid (9-cis-RA) and SR11237 on high glucose-induced inflammation in human umbilical endothelial vein endothelial cells (HUVECs) and explored the potential mechanism. RXR agonists inhibit inflammation through NADPH-NFκBOur results showed that the inflammation induced by high-glucose in HUVECs was mainly mediated by the activation of nuclear factor-B (NF-κB). High glucose-induced expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were in comparison, significantly decreased by treatment with RXR. The effect of RXR agonists was mainly due to the inhibition of NF-κB activation. Using pharmacological inhibitors and siRNA, we confirmed that nicotinamide adenine dinucleotide phosphate (NADPH) oxidase was an upstream activator of NF-κB. Furthermore, RXR agonists significantly inhibited high glucose-induced activation of NADPH oxidase and significantly decreased the production of reactive oxygen species (ROS). To explore whether the rapid inhibitory effects of RXR agonists were in fact mediated by RXR, we examined the effect of RXR downregulation by RXR siRNA. Our results showed that RXR siRNA largely abrogated the effects of RXR agonists, suggesting the requirement of RXR expression. Therefore, we have shown that RXR is involved in the regulation of NADPH oxidase-NF-κB signal pathway, as the RXR ligands antagonized the inflammatory response in HUVECs induced by high glucose.

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Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children. Do they play a role in the progression of atherosclerosis?

Cited by 38 publications

References 65 publications

HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine

HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine

Age-Related Changes in the Expression of ICAM-1 in the Aorta of Wistar Albino Rats

RXR agonists inhibit high glucose-induced upregulation of inflammation by suppressing activation of the NADPH oxidase-nuclear factor-κB pathway in human endothelial cells

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