Off-site construction has become an emerging research domain in the recent decade. Through a holistic review approach incorporating scientometric analysis and follow-up in-depth qualitative analysis, this study contributes to the body of knowledge in off-site construction by summarizing the latest research keywords and main research topics. This study also identifies the current gaps in research and practice, as well as proposing future research directions in this research area. Off-site construction is a domain that can be extended to cross-disciplinary research from the perspectives of engineering, management, and technology. Existing research have been focusing on many research disciplines, such as structural behaviors and joint connections of prefabricated components, scheduling and planning of off-site activities, as well as performance evaluation of off-site construction. However, further research is needed in integrating the emerging digital construction technology, integrated project delivery method, lean construction, and the issues of sustainability of off-site construction. There are already limited studies linking off-site construction to the concept of Design for Manufacturing and Assembly. Future research should also adopt a larger database and allow for comprehensive evaluation of off-site construction performance.