Interdental papilla reconstruction using injectable hyaluronic acid: A 6 month prospective longitudinal clinical study

Abstract

The objective of this study was to assess the efficacy of Hyaluronic Acid (HA) on interdental papilla (IDP) loss in the esthetic zone. Twenty one subjects (14 females and 7 males) from those referred for treatment of IDP loss at Periodontics postgraduate clinics at the Jordan University of Science and Technology. A total of 86 interdental sites (58 sites in the maxillary jaw and 28 sites in the mandibular jaw) were treated and followed up. A 0.2 ml of Hyaluronic acid was injected in each receded IDP site and injections were repeated after 21 days. Papilla sites were evaluated and statistically analyzed. At the 3 week interval the mean reduction of black triangle (BT) height was 0.17 mm (8% reduction) (P‐value <0.001), at the 3 month interval there was a mean reduction of BT height of 0.83 mm (39% reduction) (P‐value <0.001). At 6 months however, the reduction in BT height was 0.62 mm (29% reduction) (P‐value <0.001). Within the limitations of this study, it can be concluded that the use of commercially available HA gel for the treatment of interdental papillae loss may have promising results over the first 6 months after injection. The maximum improvement in black triangles was at 3 months after injection with a reduction of improvement between 3 and 6 months. Clinical Relevance Helping clinician to take evidence based decision while considering Hyaluronic acid injection as a short term nonsurgical treatment modality for interdental papilla loss.

Systematic Review and Meta-Analysis of the Use of Hyaluronic Acid Injections to Restore Interproximal Papillae

“…The greatest weight in this review with the lower variability was shown by Alhabashneh [16] who presented 21 (14 females, 7 males) patients and a total number of treated interdental papillary sites of 86. Overall, there was statistically significant difference in black triangle reduction between maxillary and mandibular sites at 3 and 6 months with more reduction observed in maxillary one.…”

“…The greater weight in this review was obtained by the study of Alhabashnaeh [16] with a 39.6%. Even more, it had the lowest dispersion.…”

Management of black triangle of interdental papilla using injectable carboxymethyl chitosan hydrogel with and without hyaluronic acid gel (Comparative Study)

“…The presence or absence of the interdental papilla was and still is a great concern to periodontists and patients (6) .…”

Engineering Polysaccharides for Tissue Repair and Regeneration

“…HA was used to reconstruct interdental papilla in 21 patients. [ 197 ] HA was injected into the interdental papilla loss site and reinjected every 21 d. After 6 months of treatment, the black triangle was significantly reduced. It is worth noting that HA is largely used as skincare products to improve skin health.…”