Interdigitated Electrodes and Their Possibility to Determine the Excitation Region in Neurons in Cultured Networks

The metabolic dynamics of yeast cells is controlled by electric pulses delivered through a spatially extended yeast cell/Au electrode interface. Concomitant with voltage pulses, oxygen is generated electrolytically at the electrode surface and delivered to the cells. The generation of oxygen was investigated in dependence of the applied voltage, width of the voltage pulses and temperature of the electrolytic solution. The local oxygen pulses at the electrodes lead to a transient activation of the aerobic energy metabolism of the yeast cells causing a perturbation in their energy balance. The effect of these local perturbations on the temporal dynamics of glycolysis in yeast cells is quantified in dependence of the energy state of cells.

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Spatial control of the energy metabolism of yeast cells through electrolytic generation of oxygen

Warnke

Mair

Witte

et al. 2009

Phys. Biol.

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Interdigitated Electrodes and Their Possibility to Determine the Excitation Region in Neurons in Cultured Networks

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Spatial control of the energy metabolism of yeast cells through electrolytic generation of oxygen

Spatial control of the energy metabolism of yeast cells through electrolytic generation of oxygen

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