Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial

Nunes, João Elias Dias; Cunha, Heitor Santos; Freitas, Zulmária Rezende Ramos de; Nogueira, Ana Maria Caixeta; Dâmaso, Ana Raimunda; Espindola, Foued Salmen; Cheik, Nádia Carla

doi:10.1080/02640414.2015.1080384

Cited by 12 publications

(16 citation statements)

References 32 publications

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“…We found that Zn level was lower in obese subjects, while the level of Cu was higher. Moreover, we found that the level of SOD was decreased in the obese group, indicating Zn and SOD deficiencies in obese subjects, which is line with the previous observation [7,8,28,30,31] .…”

Section: Zinc and Sod Levels In Obese Subjectssupporting

confidence: 92%

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

et al. 2016

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The oxidant-stress (OS) has an essential role to play in the pathogenesis and progression of many diseases. OS is the outcome when the level of free-radical-formation is increased or protective-antioxidant-mechanisms are compromised. Its value is expected to increase, although its emerging roles have not been conclusive in different studies. The objective of this study was to explore the level of zinc, copper, and antioxidant in response to obesity-related-stress by measuring superoxide-dismutase (SOD) levels as a key antioxidant-enzyme in 706 individuals with/without obesity. Anthropometric/biochemical parameters including total-cholesterol (TC), fasting-blood-glucose, high-density-lipoprotein (HDL), low-density-lipoprotein, and triglycerides were determined. The activity of SOD was measured followed by the measurement of Cu and Zn levels. Obese subjects had a significantly higher level of body mass index (BMI) and TC, while the level of HDL was lower in the obese group, as compared to the related values in control subjects. The level of Zn was significantly decreased in the obese group, while the level of Cu and Cu/Zn ratio increased. Additionally, we observed that the SOD level was less in obese subjects when compared to that in the non-obese subjects. In addition to the complications of high BMI, low level of Zn and SOD in obesity can be considered a risk factor, resulting in a reduced antioxidant response, supporting the need for identifying a suitable treatment option for this group.

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Section: Zinc and Sod Levels In Obese Subjectssupporting

confidence: 92%

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

et al. 2016

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“…Finally, 14 RCTs met the inclusion criteria and were included in the meta-analysis. 13, 19, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38 In the included 14 trials, 5 RCTs analyzed leptin, 19, 30, 31, 34, 36 10 analyzed adiponectin, 13, 28, 29, 31, 32, 34, 35, 36, 38 2 analyzed resistin, 31, 36 and only 1 visfatin. 33 …”

Section: Resultsmentioning

confidence: 99%

“…The youths were overweight/obese 28, 29, 31, 33, 34, 37 or obese. 13, 19, 27, 30, 35, 36, 38 Three studies included only boys 28, 32, 37 and three only girls, 33, 34, 35 and the remaining studies included both boys and girls. 13, 19, 27, 29, 30, 31, 36, 38 Participants in three studies were children (6–12 years old), 28, 29, 31 in eight adolescents (13–17 years old), 13, 19, 32, 33, 34, 35, 36, 37, 38 and in the other both age groups were included.…”

Section: Resultsmentioning

confidence: 99%

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Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

et al. 2016

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Background/Objective:Adipokines are involved in the etiology of diabetes, insulin resistance, and the development of atherosclerosis and other latent-onset complications. The objective of this meta-analysis was to determine the effectiveness of exercise interventions on adipokines in pediatric obesity.Subjects/Methods:A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of exercise interventions on adipokines (adiponectin, leptin, resistin and visfatin) in pediatric obesity (6–18 years old). Fourteen randomized controlled trials (347 youths) were included. Weighted mean difference (WMD) and 95% confidence intervals were calculated.Results:Exercise was associated with a significant increase in adiponectin (WMD=0.882 μg ml−1, 95% CI, 0.271–1.493) but did not alter leptin and resistin level. Likewise, exercise intensity and change in body fat; as well as total exercise program duration, duration of the sessions, and change in body fat all significantly influenced the effect of exercise on adiponectin and leptin, respectively.Conclusions:Exercise seems to increase adiponectin levels in childhood obesity. Our results also suggested that exercise on its own, without the concomitant presence of changes in body composition levels, does not affect leptin levels.

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“…In a 3-year longitudinal study, higher concentrations of A-FABP and lower levels of adiponectin were reported as predictors for the development of CVD risk factors [21]. The improvement of adiponectin levels after an exercise-based intervention programme has been associated with improvements in the oxidant status in paediatric populations [68].…”

Section: Blood Vessels and Blood Pressure (Bp)mentioning

confidence: 99%

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Nascimento¹,

Coimbra²,

Rêgo³

et al. 2017

Adiposity - Omics and Molecular Understanding

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Paediatric obesity has significant physic, social and psychological implications. Childhood obesity is usually associated in adulthood with increased risk of type 2 diabetes, metabolic syndrome and cardiovascular diseases. Aggregation of cardiometabolic risk factors is already observed at young ages, with a nonlinear association with enhancement of adiposity. Adiponectin is an adipokine that inhibits inflammation, oxidative stress and metabolic syndrome components, namely dyslipidaemia, high blood pressure and insulin resistance. Obesity has been associated with hypoadiponectinaemia in both adult and paediatric patients, which may contribute to co-morbidities observed in these patients. Interventional studies that aim to tackle obesity reported controversial results. Although the general positive effect on weight loss, inflammatory and cardiometabolic markers has been studied, the impact of these interventional studies on adiponectin remains unclear. Some studies reported that the improvement in adiponectin might only occur in paediatric obese patients with great weight loss or intensive physical exercise; the magnitude of the changes in body composition appears to be of particular importance. A revision about the knowledge on the relation between adiponectin, inflammation and cardiometabolic risk factors in paediatric patients is performed; the impact of interventional studies on adiponectin levels and markers of cardiometabolic risk is also addressed.

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Interdisciplinary therapy changes superoxide dismutase activity and adiponectin in obese adolescents: a randomised controlled trial

Cited by 12 publications

References 32 publications

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese Individuals

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

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