Interface Chirality: From Biological Effects to Biomedical Applications

Guo, Liang; Guo, Yanqiu; Wang, Rui; Feng, Jie; Shao, Nan; Zhou, Xiaolin; Zhou, Yunlong

doi:10.3390/molecules28155629

Cited by 6 publications

(2 citation statements)

References 69 publications

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“…These interfaces exhibit stereoselective interactions between the material and the biological macromolecule. 51 The salt bridge (−COO − , −NH 3 + , and −CH 3 ) is the primary driving force for the interaction between proteins and chiral nanointerfaces. 52 In the study of artificial biological materials, the interaction between the biointerface and the material directly determines the material's performance in the organism.…”

Section: Research Progress Of 2d Chiral Nanomaterialsmentioning

confidence: 99%

“…Chiral nanointerfaces are contact surfaces between the active outermost structure of a chiral nanomaterial and the surface of a biological structure. These interfaces exhibit stereoselective interactions between the material and the biological macromolecule . The salt bridge (−COO – , −NH 3 + , and −CH 3 ) is the primary driving force for the interaction between proteins and chiral nanointerfaces .…”

Section: Research Progress Of 2d Chiral Nanomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Zhao,

Chen,

Cheng

et al. 2024

ACS Biomater. Sci. Eng.

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Chirality, one of the most fundamental properties of natural molecules, plays a significant role in biochemical reactions. Nanomaterials with chiral characteristics have superior properties, such as catalytic properties, optoelectronic properties, and photothermal properties, which have significant potential for specific applications in nanomedicine. Biomolecular modifications such as nucleic acids, peptides, proteins, and polysaccharides are sources of chirality for nanomaterials with great potential for application in addition to intrinsic chirality, artificial macromolecules, and metals. Two-dimensional (2D) nanomaterials, as opposed to other dimensions, due to proper surface area, extensive modification sites, drug loading potential, and simplicity of preparation, are prepared and utilized in diagnostic applications, drug delivery research, and tumor therapy. Current advanced studies on 2D chiral nanomaterials for biomedicine are focused on novel chiral development, structural control, and materials sustainability applications. However, despite the advances in biomedical research, chiral 2D nanomaterials still confront challenges such as the difficulty of synthesis, quality control, batch preparation, chiral stability, and chiral recognition and selectivity. This review aims to provide a comprehensive overview of the origins, synthesis, applications, and challenges of 2D chiral nanomaterials with biomolecules as cargo and chiral modifications and highlight their potential roles in biomedicine.

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Section: Research Progress Of 2d Chiral Nanomaterialsmentioning

confidence: 99%

Section: Research Progress Of 2d Chiral Nanomaterialsmentioning

confidence: 99%

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Zhao,

Chen,

Cheng

et al. 2024

ACS Biomater. Sci. Eng.

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New 5, 6, 7, 8‐Tetrahydro‐Isoquinolines Bearing 2‐Nitrophenyl Group Targeting RET Enzyme: Synthesis, Anticancer Activity, Apoptotic Induction and Cell Cycle Arrest

Saddik,

Bakhite,

Hassanien

et al. 2024

Chemistry & Biodiversity

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In this work, we synthesized new 5,6,7,8‐tetrahydroisoquinolines and 6,7,8,9‐tetrahydrothieno[2,3‐c]isoquinolines derivatives and the structures of these new compounds were confirmed with different spectroscopic techniques. Furthermore, the anticancer activities of these compounds were assessed against eight tumor cell lines and one normal human skin fibroblast cell line (HSF). Subsequently, IC50 values of the synthesized compounds were determined for two specific cancer cell lines. Compound 3 exhibited the most potent antiproliferative activity against the HEPG2 cell line, whereas compound 9c demonstrated superior efficacy against the HCT116 cell line. Moreover, the mechanism of action for compound 3 on HEPG2 cells using flow cytometry and Annexin V‐FITC apoptosis analysis was studied. Compound 3 caused cell cycle arrest at the G2/M with a 50‐fold increase in apoptosis of the HEPG2 cell line. Finally, a molecular docking study was conducted to assess the inhibitory potential of compounds 3 and 7 against the RET enzyme. Results indicated that compounds 3 and 7 bind to the RET enzyme with binding energies of ‐5.2 and ‐5.6 kcal/mol, respectively. While these values suggest inhibitory activity, they are less potent than the standard inhibitor, alectinib, which exhibits a binding energy of ‐7.2 kcal/mol.

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Expanding the Role of Chiral Drugs and Chiral Nanomaterials as a Potential Therapeutic Tool

Satapathy,

Kumar,

Kurmi

et al. 2024

Chirality

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Chirality, the property of molecules having mirror‐image forms, plays a crucial role in pharmaceutical and biomedical research. This review highlights its growing importance, emphasizing how chiral drugs and nanomaterials impact drug effectiveness, safety, and diagnostics. Chiral molecules serve as precise diagnostic tools, aiding in accurate disease detection through unique biomolecule interactions. The article extensively covers chiral drug applications in treating cardiovascular diseases, CNS disorders, local anesthesia, anti‐inflammatories, antimicrobials, and anticancer drugs. Additionally, it explores the emerging field of chiral nanomaterials, highlighting their suitability for biomedical applications in diagnostics and therapeutics, enhancing medical treatments.

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Interface Chirality: From Biological Effects to Biomedical Applications

Cited by 6 publications

References 69 publications

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

New 5, 6, 7, 8‐Tetrahydro‐Isoquinolines Bearing 2‐Nitrophenyl Group Targeting RET Enzyme: Synthesis, Anticancer Activity, Apoptotic Induction and Cell Cycle Arrest

Expanding the Role of Chiral Drugs and Chiral Nanomaterials as a Potential Therapeutic Tool

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