Interfacial science and the creation of nanoparticles

Dungan, Stephanie R.

doi:10.1002/9781118462157.ch4

Cited by 1 publication

(1 citation statement)

References 65 publications

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“…In this sense, the release of hydrophilic drugs, such as Ins, from micelles is a rapid process, due to the fast removal of the drug from the medium that creates an augmented aqueous concentration difference and thus enhancing the migration of molecules. Nonetheless, for poorly water-soluble drugs, such as Rho, the release from micelles is slower, due to high affinity for the lipid constituents and therefore, the migration and transfer of drugs to water are less favored [60]. In this sense, LCMs made of Gelucire 44/14 ® may serve as drug delivery systems when a modified or controlled release of the entrapped poorly water-soluble drug is desired.…”

Section: In Vitro Release Profiles Of Rhodamine 123 and Insulinmentioning

confidence: 99%

Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs

et al. 2020

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The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding spherically shaped, small-sized, monodispersed and negatively charged carriers with high entrapment efficiency. In vitro release studies demonstrated a higher release of insulin rather than rhodamine from LCMs in simulated physiological conditions, due to an initial burst release effect; however, both release profiles are mainly explained by a diffusion mechanism. Furthermore, LCMs-loaded mucoadhesive films were manufactured and preserved with similar mechanical properties and optimal mucoadhesive behavior compared to nonloaded films. Ex vivo permeation experiments using excised porcine buccal epithelium reveal that both rhodamine and insulin-loaded LCM films elicited a significantly enhanced permeation effect compared to LCMs in suspension and free drugs in solution as controls. Hence, LCMs-loaded mucoadhesive films are suitable as buccal dosage form for the transport and delivery of rhodamine 123 and insulin, as models for poorly water-soluble and biological drugs, respectively.

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Section: In Vitro Release Profiles Of Rhodamine 123 and Insulinmentioning

confidence: 99%