Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes

Jin, Lin; Jiang, Bao-Gui; Yin, Yizhu; Guo, Jingya; Jiang, Jia-Fu; Qi, Xiaopeng; Crispell, Gary; Karim, Shahid; Cao, Wu‐Chun; Lai, Ren

doi:10.1073/pnas.2208274119

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Lesi kulit sering dimulai dari wajah dan kaki depan dan dapat berkembang hingga memengaruhi bagian tubuh lain (Mueller et al, 2012). Pruritus dapat disebabkan karena infeksi tungau Demodex, saliva caplak, ataupun infeksi sekunder oleh bakteri atau jamur (Rangsan dan Arkom, 2010;Jin et al, 2022).…”

Section: Pemeriksaan Ulas Darahunclassified

Ehrlichiosis and Demodicosis in Bali Local Dog

Ma’arif,

Jayanti,

Soma

2024

bulvet

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Ehrlichiosis is a zoonotic disease caused by infection with intracellular bacteria Ehrlichia sp. which can be transmitted by ticks. Demodicosis is a parasitic disease caused by the mite Demodex sp. which has a predilection for the dermis, hair follicles, and sebaceous glands. A male local breed dog aged approximately 2 years with a body weight of 8 kg came with complaints of hair loss and high intensity itching with a scale of 8/10. The results of clinical examination showed alopecia, scale, and erythema almost all over the body accompanied by tick infestations found on the back, anemic mucosa, left prescapularis lymph nodes and left popliteus experienced swelling. Hematological examination showed macrocytic hypochromic anemia, leukocytosis, lymphocytosis, granulocytosis, and thrombocytopenia. Blood smear and serology examination showed Ehrlichia sp.. infection while deep skin scrapping examination showed Demodex sp. infection. Based on the anamnesis, physical examination and laboratory examination, the case of the dog suffering from ehrlichiosis accompanied by demodecosis. The therapy given was in the form of doxycycline, ivermectin, diphenydramine, vitamin B complex, and bath therapy with sulfur soap. Observation of therapy on the 14th day provided clinical improvement in terms of reducing itching intensity, Demodex sp. infection intensity, and hematological parameters. On the 28th day of the last treatment, the dog's body condition was getting better, new hair started to grow and the body condition score increased. Dogs should be given food rich in nutrients such as liver, meat and egg yolks, as well as providing nutritional supplements to speed up the dog's recovery.

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Section: Pemeriksaan Ulas Darahunclassified

Ehrlichiosis and Demodicosis in Bali Local Dog

Ma’arif,

Jayanti,

Soma

2024

bulvet

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Host skin immunity to arthropod vector bites: from mice to humans

Lacsina,

Kissinger,

Doehl

et al. 2024

Front. Trop. Dis

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Infections caused by vector-borne pathogens impose a significant burden of morbidity and mortality in a global scale. In their quest for blood, hematophagous arthropods penetrate the host skin and may transmit pathogens by the bite. These pathogens are deposited along with saliva and a complex mixture of vector derived factors. Hematophagous arthopod vectors have evolved a complex array of adaptations to modulate the host immune response at the bite site with the primary goal to improve blood feeding, which have been exploited throughout evolution by these pathogens to enhance infection establishment in the host. While this paradigm has been firmly established in mouse models, comparable data from human studies are scarce. Here we review how the host skin immune response to vector bites in animal models is hijacked by microbes to promote their pathogenesis. We mainly explored four distinct vector-pathogen pairs of global health importance: sand flies and Leishmania parasites, Ixodes scapularis ticks and Borrelia burgdorferi, Aedes aegypti mosquitoes and arboviruses, and Anopheles gambiae mosquitos and Plasmodium parasites. Finally, we outline how critical it is for the field of vector biology to shift from rodent models to clinical studies focused on the interface of vector-pathogen-host immune system to push further the frontiers of knowledge of the field.

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Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes

Cited by 2 publications

References 54 publications

Ehrlichiosis and Demodicosis in Bali Local Dog

Ehrlichiosis and Demodicosis in Bali Local Dog

Host skin immunity to arthropod vector bites: from mice to humans

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