Interference with thyrotropin receptor antibody determination by a spuriously occurring anti-bovine TSH antibody

Iitaka, Makoto; Tanikawa, Toshinori; Sakatsume, Yoshiki; Yanagisawa, Mitsuru; Hara, Yuki; Ishii, Jun

doi:10.1530/acta.0.1120197

Cited by 5 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 in Table 3) had antibodies to both mouse IgG and bovine TSH. Antibodies to bovine TSH interfere with the TSH receptor antibody assay and cause extremely negative TRAb values (21). It is interesting to speculate about whether this patient is prone to develop such heterophilic antibodies.…”

Section: Discussionmentioning

confidence: 89%

Incidence of Anti-Mouse IgG in normal subjects and Patients with Autoimmune Thyroid Disease.

et al. 1992

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 89%

Incidence of Anti-Mouse IgG in normal subjects and Patients with Autoimmune Thyroid Disease.

et al. 1992

Self Cite

View full text Add to dashboard Cite

Anti-bovine thyrotropin autoantibodies in patients with Hashimoto’s thyroiditis, subacute thyroiditis, and systemic lupus erythematosus

Sakata

Takuno

Nagai

et al. 1991

J Endocrinol Invest

View full text Add to dashboard Cite

We report four cases found to have anti-bovine thyrotropin (bTSH) antibodies, two with Hashimoto's thyroiditis and the other two, each with subacute thyroiditis and systemic lupus erythematosus (SLE). The unusually high negative titers of anti-TSH receptor antibodies (Case no. 1, -43.1%; Case no. 2, -34.9%; Case no. 3, -55.2%; Case no. 4, -59.9%) led to the incidental finding of the presence of anti-bovine (bTSH) antibodies in each patient. Case no. 1 was diagnosed to have Hashimoto's thyroiditis and was treated with L-thyroxine (L-T4). With the treatment, serum free T4 (FT4)normalized with a decline in the serum TSH concentration. The other patient diagnosed to have Hashimoto's thyroiditis (Case no. 2) remained euthyroid even without supplemental thyroid hormone therapy and the serum concentrations of FT4 and TSH stayed within the normal range. The third is a case of subacute thyroiditis (Case no. 3) with a typical clinical course of the disease. She had the anti-bTSH antibodies on her first outpatient visit. Serial examination of her sera disclosed the antibody titers to be on the same range over the 28 months after the onset of the symptoms. The fourth is a patient with SLE who had been treated with steroid (alternative day therapy of 40 mg/day prednisolone). Titers of the anti-bTSH antibodies spontaneously declined to the negative level 5 months later. None of the four cases had antibodies against human TSH alpha-subunit of bovine LH and alpha-subunit of bovine FSH.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Clinical significance of anti-TSH antibody in sera from patients with Graves’ disease and other thyroid disorders

Akamizu

Mori

Imura

et al. 1989

J Endocrinol Invest

View full text Add to dashboard Cite

In a survey of patients having anti-TSH antibody (TSH Ab), data from 167 subjects were collected from 8 Japanese Institutions. They were divided into a high TSH Ab group consisting of 63 cases; since the means of assay was via a subnormal thyrotropin binding inhibitor immunoglobulin (TBII) assay, this group had TBII values less than -20%. An additional low TSH Ab group was made up of 104 cases. Out of a total of 11,211 patients, the incidence of TSH Ab for the high and low groups were 0.57% and 13.4%, respectively. More than 95% of these TSH Ab carriers had Graves' disease or some other autoimmune thyroid disorder, and anti-thyroglobulin and anti-thyroid microsomal antibodies were detected similarly in both groups. It was significant that TSH receptor antibodies could also be detected in both groups, namely, thyroid stimulating antibody and long acting thyroid stimulator (LATS) in 4 of 9 patients in the high TSH Ab group and TBII in 55 of 104 in the low TSH Ab group, respectively. The high TSH Ab levels tended to persist, but 26% of cases showed disappearance or appearance of the antibody during the observation period. In one Graves' patient, a moderate TBII activity (64.2%) was followed by markedly elevated TSH Ab (TBII: -83.4%) within 2 months. The TSH Ab in the low TSH Ab group disappeared in most cases. Also, fluctuations in TSH Ab did not always parallel those seen for TBII and reciprocal fluctuation pattern (transient or otherwise) were observed in 33%. In conclusion, anti-TSH antibody is produced frequently in patients with either Graves' disease or some other autoimmune thyroid disorder.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Interference with thyrotropin receptor antibody determination by a spuriously occurring anti-bovine TSH antibody

Abstract: Abnormally negative values of thyrotropin binding inhibitor immunoglobulin (TBII) were found in the sera from a patient with Graves' disease. This was due to the presence of potent bovine TSH (bTSH)

Cited by 5 publications

References 14 publications

Incidence of Anti-Mouse IgG in normal subjects and Patients with Autoimmune Thyroid Disease.

Incidence of Anti-Mouse IgG in normal subjects and Patients with Autoimmune Thyroid Disease.

Anti-bovine thyrotropin autoantibodies in patients with Hashimoto’s thyroiditis, subacute thyroiditis, and systemic lupus erythematosus

Clinical significance of anti-TSH antibody in sera from patients with Graves’ disease and other thyroid disorders

Contact Info

Product

Resources

About