Interferon Alpha-2a Monotherapy for Necrobiotic Xanthogranuloma

Abstract

out preceding bullous lesion and healed after oral corticosteroids (5, 6).In our patient the titre of circulating anti-ICS antibodies was low, which might indicate a prolonged initial phase of PV before generalized development of bullae. The massive plasma cell in®ltrate seen in the lesional upper dermis may be a factor for the localization of the lesions. Another possibility is that an unknown mechanism prevents the generalization of PV, resulting in the unique features described above. Since acanthosis was seen histologically, the diagnosis of pemphigus vegetans is also possible. 2. Jacyk WK, Simson IW. Pemphigus erythematosus resembling multiple seborrheic keratoses. Arch Dermatol 1990; 126: 543 ± 544. 3. Faber WR, Neumann HAM, Flinterman J. Persistent vegetating and keratotic lesions in patients with pemphigus vulgaris during immunosuppressive therapy. Br J Dermatol 1983; 109: 459 ± 463. 4. Yesudian PD, Krishnan SGS, Jayaraman M, Janaki VR, Yesudian P. Postpemphigus acanthomata: a sign of clinical activity? Int J Dermatol 1997; 36: 194 ± 196. 5. Bruckner N, Kats RA, Hood AF. Pemphigus foliaceus resembling eruptive seborrheic keratoses. Arch Dermatol 1980; 116: 815 ± 816. 6. Kahana M, Trau H, Schewach-Millet M, Sofer E. Pemphigus foliaceus presenting as multiple giant seborrheic keratoses.

A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria

“…In the systematic review, the initial search yielded 1199 records, 151 of which were included (Figure). These reports described 201 patients with NXG, with demographics, comorbidities, and clinical features (detailed in the eTable in the Supplement).…”

A 7-Year History of Necrobiotic Xanthogranuloma following Asymptomatic Multiple Myeloma: A Case Report

“…Chlorambucil appears to be the most effective treatment for patients with extensive cutaneous lesions [15–17]. Other systemic agents have been employed with some improvement including systemic steroid [18, 19], chlorambucil plus systemic corticosteroids, [7] cyclophosphamide, [20] melphalan, [21, 22] melphalan plus systemic corticosteroids, [23–25] azathioprine plus systemic corticosteroids, [26] thalidomide [27], and interferon- α 2b [7, 28]. All treatments can produce remission of paraproteinemia as well as skin lesions but, unfortunately, cannot prevent the evolution to multiple myeloma.…”

Spectacular skin nodules: Cutaneous necrobiotic xanthogranuloma without paraproteinemia

“…Improvement in skin lesions has been seen with low-dose chlorambucil,[9] melphalan with or without prednisolone, methotrexate, localized radiotherapy,[10] systemic glucocorticoids,[11] interferon α-2a,[12] and plasmapheresis with hydroxychloroquine. [13] Topically nitrogen mustard, BNCU, intralesional corticosteroids and intravenous immunoglobulin[2] have also been tried.…”