Interferon and natural killer cell activity in coxsackie virus B3-induced murine myocarditis

Differential Regulation of GM1 and Asialo-GM1 Expression by T Cells and Natural Killer (NK) Cells in Respiratory Syncytial Virus Infection

“…The anti-ASGM1 Ab has been used to assess the in vivo role of NK cells in several viral models (34)(35)(36)38,41,44). Our results agree with those of Slifka et al, who showed that anti-ASGM1 Ab depletes activated T cells in a mouse model of viral infection (48).…”

“…Anti-ASGM1 Ab has been used to deplete NK cells in mice (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). However, it has been known for some time that ASGM1 can be upregulated on leukocytes other than NK cells in the context of viral infection (45).…”

Coxsackievirus B4 infection of the mouse pancreas: the role of natural killer cells in the control of virus replication and resistance to infection

“…Other workers have also reported peak CVB replication 2 to 4 days p.i. (Godeny & Gauntt, 1986;Woodruff & Woodruff, 1974;Loria et al, 1984;Wolfgram et al, 1986). Virus could still be recovered from the pancreas of six strains 7 to 8 days p.i.…”

“…Although a variety of DNA and RNA viruses augment NK cell activity in mice (Welsh, 1986), the role of these cells in the early control of virus replication has been investigated for only a few viruses. For example, studies in mice infected with herpes simplex virus type 1 (Habu et al, 1981), murine cytomegalovirus (Bukowski et al, 1983(Bukowski et al, , 1984, coxsackievirus B3 (CVB3) (Godeny & Gauntt, 1986 and more recently the encephalomyocarditis virus D variant (EMC-D) (White & Smith, 1990) have shown that NK cell activity peaks 2 to 4 days post-infection (p.i.). Mice depleted of NK cells using anti-asialo GM1 (anti-AGM1) antibody, which binds to a neutral glycolipid (ganglio-n-tetraosylceramide) ex-pressed on the surface of NK cells (Kasai et al, 1980), develop more extensive lesions on challenge infection than untreated controls.…”

The Key Players of Coxsackievirus-Induced Myocarditis

“…Tomioka and colleagues investigated neutralizing antibodies and their role in virus-induced myocarditis and B-cell-mediated immunity using BALB/c mice (Esfandiarei et al 2008). NK-deficient mice have been used to look at the role of natural killer (NK) cells in killing virus-infected cardiomyocytes (Godeny et al 1986). Perforin knockout mice inoculated with coxsackievirus B3 have also been used to describe the interplay of virus infection and lymphocyte infiltration in the myocytes and their effect on disease outcome (Godeny et al 1987).…”