Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis

Bozzi, Adriana; Reis, Bernardo Sgarbi; Pereira, Paulolinto; Pedroso, E.P.; Góes, Alfredo M.

doi:10.1016/j.cyto.2009.07.011

Cited by 24 publications

(18 citation statements)

References 30 publications

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“…The SNP at the -183G>T position is related to increased transcription activity [26], whereas +874A>T is located in a region where the number of replicates can modulate the expression of messenger RNA and the production of cytokines [21, 72]. The T allele is associated with a high number of replicate copies and activates the transcription site for the NF- κ B pathway, which correlates with high cytokine expression [73, 74]. The AA, TA, and TT genotypes are associated with low, intermediate, and high production of IFN- γ , respectively [21, 75].…”

Section: Discussionmentioning

confidence: 99%

Frequency ofTNFA,INFG, andIL10Gene Polymorphisms and Their Association with MalariaVivaxand Genomic Ancestry

Furini

Cassiano

Capobianco

et al. 2016

Mediators of Inflammation

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Polymorphisms in cytokine genes can alter the production of these proteins and consequently affect the immune response. The trihybrid heterogeneity of the Brazilian population is characterized as a condition for the use of ancestry informative markers. The objective of this study was to evaluate the frequency of -1031T>C, -308G>A and -238G>A TNFA, +874 A>T IFNG and -819C>T, and -592C>A IL10 gene polymorphisms and their association with malaria vivax and genomic ancestry. Samples from 90 vivax malaria-infected individuals and 51 noninfected individuals from northern Brazil were evaluated. Genotyping was carried out by using ASO-PCR or PCR/RFLP. The genomic ancestry of the individuals was classified using 48 insertion/deletion polymorphism biallelic markers. There were no differences in the proportions of African, European, and Native American ancestry between men and women. No significant association was observed for the allele and genotype frequencies of the 6 SNPs between malaria-infected and noninfected individuals. However, there was a trend toward decreasing the frequency of individuals carrying the TNF-308A allele with the increasing proportion of European ancestry. No ethnic-specific SNPs were identified, and there was no allelic or genotype association with susceptibility or resistance to vivax malaria. Understanding the genomic mechanisms by which ancestry influences this association is critical and requires further study.

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Section: Discussionmentioning

confidence: 99%

Frequency ofTNFA,INFG, andIL10Gene Polymorphisms and Their Association with MalariaVivaxand Genomic Ancestry

Furini

Cassiano

Capobianco

et al. 2016

Mediators of Inflammation

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“…These data were derived from a patient cohort with acute leukemia and no data on cytokine levels are available. Another study revealed altered IL-4 levels in patients with paracoccidioidomycosis [67] . IL-13 is a cytokine that, among other functions, inhibits inflammatory cytokine production.…”

Section: Pro-inflammatory Cytokinesmentioning

confidence: 99%

Genetic Variation in Innate Immunity Pathways and Their Potential Contribution to the SIRS/CARS Debate: Evidence from Human Studies and Animal Models

Kumpf¹,

Schumann²

2010

J Innate Immun

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The lack of a causal and successful treatment for sepsis has led to a re-evaluation of the condition’s pathopysiology. The failure of anti-inflammatory strategies has implied compensatory immunosuppression to play a central part in fatal clinical cases. While searching for novel therapeutic strategies, the question arose whether pro-inflammation (systemic inflammatory response syndrome, SIRS) or anti-inflammation (compensatory anti-inflammatory response syndrome, CARS) are dominant in sepsis, and may be counteracted by therapeutic measures. Here we ask whether in a given organism – man or mouse – the lack of any functional protein involved in this cascade may help in understanding the events. In humans, genetic variations exist, and some of them have functional consequences altering the inflammatory response to pathogens. In mice, knockout animals were created, which may assist us in understanding the SIRS/CARS cascade. Here we summarize data on genetic variations in the TLR- and cytokine system and their influence on course of infectious diseases and sepsis. In addition, we summarize animal experiments and conclude that both cascades may be needed for containing infection. Imbalances in both the pro- and anti-inflammatory system may be harmful. Thus, interventional strategies have to be introduced carefully, and in the future genetic profiling may be needed in order to tailor therapies in the best way.

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“…Resistance or mild manifestation of the disease has been related to IFN-γ and TNF-α production, while increased susceptibility to disease phenotypes are observed associated with a predominant production of Th2 interleukins IL-4, IL-5, IL-10 and IL-13. 80 Molecular genetic studies have shown evidence of association of PCM with specific variants of immune response-related genes. Specific alleles of the TNFA (-308) polymorphism were associated with PCM in a small case-control population sample from Brazil.…”

Section: Other Infectious Diseases Of Interest In Dermatology Paracocmentioning

confidence: 99%

“…For IL4, the susceptibility C/T genotype was associated with higher production of this cytokine. 80,81 Chromoblastomycosis Chromoblastomycosis is a chronic mycosis involving the skin and subcutaneous tissue. A large number of melanized (dematiaceous) fungi have been associated with the disease, the most common being Fonsecaea pedrosoi and Cladophialophora carrioni.…”

Section: Other Infectious Diseases Of Interest In Dermatology Paracocmentioning

confidence: 99%

“…The disease presents a broad spectrum of clinical and pathological manifestations, ranging from localized lesions to severely disseminated infection. 80 Effective defense against P. braziliensis depends mainly upon the ability of the host to mount an efficient, Th1-type of acquired resistance modulated by the interaction of T cells and macrophage-activating cytokines. Resistance or mild manifestation of the disease has been related to IFN-γ and TNF-α production, while increased susceptibility to disease phenotypes are observed associated with a predominant production of Th2 interleukins IL-4, IL-5, IL-10 and IL-13.…”

Section: Other Infectious Diseases Of Interest In Dermatology Paracocmentioning

confidence: 99%

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Genetic risk factors for human susceptibility to infections of relevance in dermatology

Sardinha

Tarlé

Fava

et al. 2011

An. Bras. Dermatol.

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BACKGROUND: In the pre-microbiological era, it was widely accepted that diseases, today known to be infectious, were hereditary. With the discovery of microorganisms and their role in the pathogenesis of several diseases, it was suggested that exposure to the pathogen was enough to explain infection. Nowadays, it is clear that infection is the result of a complex interplay between pathogen and host, therefore dependant on the genetic make-up of the two organisms. Dermatology offers several examples of infectious diseases in different stages of understanding of their molecular basis. In this review, we summarize the main advances towards dissecting the genetic component controlling human susceptibility to infectious diseases of interest in dermatology. Widely investigated diseases such as leprosy and leishmaniasis are discussed from the genetic perspective of both host and pathogen. Others, such as rare mycobacterioses, fungal infections and syphilis, are presented as good opportunities for research in the field of genetics of infection. Keywords: Dermatology; Infection; Polymorphism, genetic Resumo: INTRODUÇÃO: Durante a era pré-microbiológica, era comum a visão de que doenças, hoje sabidamente infecciosas, eram hereditárias. Com a descoberta dos microorganismos e seu papel na patogênese de diversas patologias, chegou-se a propor que a exposição ao patógeno era condição suficiente para explicar infecção. Hoje, está claro que infecção é o resultado de uma complexa interação entre patógeno e hospedeiro, dependendo portanto, em última análise, do make-up genético de ambos os organismos. A dermatologia oferece diversos exemplos de doenças infecciosas em diferentes graus de entendimento de suas bases moleculares. Nesta revisão, resumimos os principais avanços na direção da dissecção do componente genético controlando suscetibilidade do ser humano a doenças infecciosas de importância na dermatologia. Doenças amplamente estudadas, como a hanseníase e a leishmaniose, são discutidas sob o ponto de vista da genética tanto do hospedeiro quanto do patógeno. Outras, como micobacterioses raras, micoses e sífilis, são apresentadas como boas oportunidades para pesquisa na área de genética de infecção.

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Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis

Cited by 24 publications

References 30 publications

Frequency ofTNFA,INFG, andIL10Gene Polymorphisms and Their Association with MalariaVivaxand Genomic Ancestry

Frequency ofTNFA,INFG, andIL10Gene Polymorphisms and Their Association with MalariaVivaxand Genomic Ancestry

Genetic Variation in Innate Immunity Pathways and Their Potential Contribution to the SIRS/CARS Debate: Evidence from Human Studies and Animal Models

Genetic risk factors for human susceptibility to infections of relevance in dermatology

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