Interferon gamma polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

Lee, Shih Wei; Chuang, Tsu‐Yi; Huang, Hsiu Han; Lee, Kuei Fang; Chen, Tina Tu Wen; Kao, Ying-Jer; Wu, Lawrence Shih Hsin

doi:10.1016/j.jmii.2013.11.009

Cited by 28 publications

(16 citation statements)

References 16 publications

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“…Statistical analysis showed that genotype TA causes a 1.76‐fold increase in susceptibility to TB (Table ). Our findings are in accordance with those of previous studies in Taiwanese populations and populations of southeastern Iran .…”

Section: Discussionsupporting

confidence: 93%

The association of interferon‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis

Mansouri

Heydarzadeh

Yousefi

2018

APMIS

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Susceptibility to tuberculosis and progression of the disease depend on interactions between the bacterial agent, host immune system, and environmental and genetic factors. In this case-controlled study, we aimed to determine the role of single-nucleotide polymorphisms of interferon-gamma, interleukin-4 and interleukin-17 in susceptibility to tuberculosis. Genomic DNA was extracted from peripheral blood samples of patients and controls. The association of single-nucleotide polymorphisms in interleukin-4 (-590C/T), interleukin-17 (-152A/G) and interferon-gamma (+874T/A) was investigated by polymerase chain reaction (PCR)-restriction fragment length polymorphism and amplification refractory mutation system-PCR. A total of 76 tuberculosis patients and 119 healthy individuals were included in this study. The interferon-gamma (+874T/A) TA genotype was significantly associated with susceptibility to tuberculosis in patients compared to controls (OR = 1.76; 95%CI = 0.84-3.71; p = 0.007), while the interferon-gamma (+874T/A) TT genotype (OR = 0.51; 95%CI = 0.19-1.36; p = 0.007) had protective effects against tuberculosis and was related to a low risk of tuberculosis development. The difference between allelic and genotypic frequencies of interleukin-4 (-590C/T) between patients and controls was not significant (p = 0.46). Multivariate logistic regression analysis revealed that the interleukin-17 (-152A/G) AG genotype (OR = 2.27; 95%CI = 1.19-4.34; p = 0.03) and AA genotype (OR = 1.03; 95%CI = 0.43-2.44; p = 0.03) were significantly different between patients and controls. In conclusion, single-nucleotide mutations in different cytokine genes may have protective effects or increase the risk of tuberculosis.

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Section: Discussionsupporting

confidence: 93%

The association of interferon‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis

Mansouri

Heydarzadeh

Yousefi

2018

APMIS

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“… P h : value of Q -test for heterogeneity test; P : Z -test for the statistical significance of the OR. HWE: Except for seven studies[ 20 , 25 , 30 , 34 , 40 , 42 , 47 ], the distribution of genotypes in the controls in remaining 35 studies was in agreement with HWE, and it reports the meta-analysis results of studies showing no deviation from the HWE. …”

Section: Resultsmentioning

confidence: 93%

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosis

Zhang

Shen

et al. 2017

Oncotarget

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Interferon-γ (Interferon gamma, IFNG) is an important cytokine involved in providing resistance to mycobacterial diseases. Common variants of IFNG, such as IFNG +874 T/A(rs2430561), may be related to tuberculosis susceptibility, but this association has not been consistently observed. We performed an updated meta-analysis to evaluate the association between the IFNG +874 T/A (rs2430561) polymorphism and tuberculosis susceptibility. PubMed and SinoMed databases were searched up to October 2016, and odds ratios (OR) and 95% confidence intervals (CI) were used to assess the association strength. Based on search criteria for manuscripts reporting tuberculosis susceptibility and its relationship with the IFNG +874 T/A(rs2430561)polymorphism, 42 case-control studies from 39 different articles were retrieved. Significantly positive, decreased, and protective associations were found between the IFNG +874 T/A(rs2430561)polymorphism and tuberculosis risk in five genetic models. Moreover, in the stratified subgroup analysis, a protective relationship was detected in four different ethnicities and sources of the control groups. Furthermore, the IFNG +874 T/A(rs2430561)polymorphism played an important role in protecting individuals from both pulmonary tuberculosis and extra-pulmonary tuberculosis. Our meta-analysis suggests that the IFNG +874 T/A(rs2430561)polymorphism is potentially associated with tuberculosis susceptibility and may be used as a predictive biomarker. Further studies with larger sample sizes and consideration of gene-environment interactions should be conducted to elucidate the role of IFNG +874 T/A(rs2430561) polymorphism in tuberculosis susceptibility.

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“…[12] Bunun dışında VDBP proteinin bronkoalveoler lavaj sıvısında bulunması nedeniyle kronik obstrüktif akciğer hastalığı (KOAH), tüberküloz gibi hastalıklarda işlevi olabileceği düşünülmektedir. [13] Akciğer patogenezinde yer alan en önemli etmenlerden biri de tütün kullanımıdır. Sigara dumanında bulunan birçok toksik ve karsinojenik bileşen DNA, protein ve lipidler ile etkileşime girerek normal fizyolojik işlevin bozulmasına ve sağlık sorunlarına neden olmaktadır.…”

Section: Bulgularunclassified

“…[7] Son yıllarda ayrıca VDBP'nin kardiyovasküler hastalıklar, otoimmün bozukluklar, diyabet, astım, Alzheimer ve tüberküloz gelişiminde ve çeşitli kanserlerde görevler aldığına dair kanıtların bulunduğu çalışmalar bulunmasına rağmen, eldeki veriler birbiriyle çelişir niteliktedir. [7][8][9][10] Bu nedenle çalışmamızda GC geninin farklı alellerinin akciğer kanser etyolojisindeki yerini araştırmayı hedefledik. …”

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Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer

Baykara¹

2017

Turk Gogus Kalp Dama

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ÖZBul gu lar: Hastaların %32.4'ünde 1S-2, %28.6'sında 1F-1S, %28.6'sında 1S-1S, %7.8'inde 1F-2 ve %2.6'sında 1F-1F genotipi bulunurken kontrol grubunda genotip frekansı sırasıyla %28, %24, %36, %4 ve %8 idi (p= 0.35). Results:Of the patients, the genotype 1S-2 was found in 32.4%, 1F-1S in 28.6%, 1S-1S in 28.6%, 1F-2 in 7.8% and 1F-1F in 2.6%, while the genotype frequencies in control group were 28%, 24%, 36%, 4% and 8%, respectively (p= 0.35). So nuç: Conclusion:We did not detect any relationship between vitamin D binding protein gene polymorphisms and lung cancer.

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Interferon gamma polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population

Abstract: The IFN-γ polymorphisms, rs1861494, rs2069718, and rs2430561, may confer the risk of TB in Han Taiwanese.

Cited by 28 publications

References 16 publications

The association of interferon‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis

The association of interferon‐gamma, interleukin‐4 and interleukin‐17 single‐nucleotide polymorphisms with susceptibility to tuberculosis

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosis

Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer

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