Interferon‐gamma release assays can effectively screen migrants for the tuberculosis infection, but urgent, active cases need clinical recognition

Nejat, Sahar; Bennet, Rutger

doi:10.1111/apa.13386

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…Many children returning after prolonged visits to these countries are also screened. The prevalence of IGRA‐diagnosed TB infection at new‐entrant screening of children from high‐incidence countries with a median age of 14 years was 8%—19% in Stockholm, which agrees with reports from other centres …”

Section: Introductionsupporting

confidence: 88%

Foreign background and older age of children were associated with infection in Swedish tuberculosis contacts

2020

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Aim We present our results using interferon‐gamma release assays in any child <18 years or tuberculin skin tests in Bacille Calmette‐Guérin unvaccinated children for tuberculosis contact investigation in Stockholm, Sweden. Methods During 2000—2019, we investigated 892 children with a median age of seven years. We explored associations between TB infection and characteristics such as closeness to contact, age, sex, BCG status and foreign origin. Results The overall rates were for TB infection 10.2% (n = 91) and for TB disease 1.1% (n = 10). In addition to infectiousness of index case and closeness of contact, foreign background, male sex and increasing age were independently associated with infection. In foreign‐born children, the rates of tuberculosis infection and disease were 18.7% and 3.9%, respectively. In 18/46 (39%) infected foreign‐born children, a baseline negative tuberculosis test supported a diagnosis of recent infection. Conclusion Foreign background, older age and male sex were associated with infection. In a significant proportion of infected children, a previous negative test made recent infection likely.

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Section: Introductionsupporting

confidence: 88%

Foreign background and older age of children were associated with infection in Swedish tuberculosis contacts

2020

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“…Nine articles discuss respiratory health [61,[186][187][188][189][190][191][192][193]. AMC in Israel, the United States, and the Netherlands report issues with asthma; however, most show a lower prevalence and better health-related quality of life, compared to local children [186][187][188].…”

Section: Respiratory Healthmentioning

confidence: 99%

“…AMC in Israel, the United States, and the Netherlands report issues with asthma; however, most show a lower prevalence and better health-related quality of life, compared to local children [186][187][188]. Authors report issues with tuberculosis (TB) among AMC in the United States, Sweden, Israel, and Australia [61,[189][190][191][192][193]. The appearance of this disease has been linked to lower height-forage z scores [61].…”

Section: Respiratory Healthmentioning

confidence: 99%

A Scoping Review of the Health of African Immigrant and Refugee Children

Salami

Fernández‐Sánchez

Fouché

et al. 2021

IJERPH

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Migration is a growing phenomenon around the world, including within the African continent. Many migrants, especially African children, face challenges related to health and social inclusion and can face increased health risks. A systematic scoping review of available literature on the health of African migrant children across the globe was conducted to offer insight into these health risks. The review was conducted over a 15-month period from January 2019 to April 2020, yielding 6602 articles once duplicates were removed. This search included electronic databases, reference lists of articles reviewed, and searches of libraries of relevant organisations. A total of 187 studies met the inclusion criteria, of which 159 were quantitative, 22 were qualitative, and 6 used mixed methods. The findings reveal decreased health in this population in areas of nutrition, infectious diseases, mental health, birth outcomes, sexual and reproductive health, physical and developmental health, parasitic infections, oral health, respiratory health, preventative health, endocrine disorders, health care services, and haematological conditions. The findings offer insights into factors influencing the health of African immigrant and refugee children. Further studies, especially qualitative studies, are needed to determine barriers to service access after migration and to investigate other underexplored and overlooked health concerns of African migrant children, including pneumonia and child maltreatment.

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“…TST has, to a large extent, been replaced by IGRA in developed countries, and this change has been accelerated by the shortage of TST reagents. IGRA has made it possible to avoid false‐positive results and overtreatment of LTBI .…”

Section: Discussionmentioning

confidence: 99%

Paediatric tuberculosis cases increased in Stockholm from 1971 to 2015 following the rising number of children with immigrant backgrounds

Bennet

Eriksson

2016

Acta Paediatrica

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Interferon‐gamma release assays can effectively screen migrants for the tuberculosis infection, but urgent, active cases need clinical recognition

Abstract: IGRAs showed higher specificity than TST in identifying tuberculosis. TB screening should focus on migrants from high-incidence countries, but this may be inadequate to detect advanced TB cases.

Cited by 7 publications

References 14 publications

Foreign background and older age of children were associated with infection in Swedish tuberculosis contacts

Foreign background and older age of children were associated with infection in Swedish tuberculosis contacts

A Scoping Review of the Health of African Immigrant and Refugee Children

Paediatric tuberculosis cases increased in Stockholm from 1971 to 2015 following the rising number of children with immigrant backgrounds

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