Interferon-?-induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 (B7.1), and inconsistent HLA-ABC expression in basal cell carcinoma: a possible role for interleukin-10?

Kooy, Angela J. W.; Prens, Errol P.; Heukelum, A. van; Vuzevski, V.D.; Joost, Theodoor van; Tank, Bhupendra

doi:10.1002/(sici)1096-9896(199902)187:3<351::aid-path227>3.0.co;2-6

Cited by 41 publications

(33 citation statements)

References 26 publications

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“…Ultraviolet exposure produces an increase in immunosuppressive cytokines, including tumor necrosis factor alpha, interleukin (IL) 1, IL 10, and prostaglandins. [29][30][31] Signaling Pathways…”

Section: Epidemiologymentioning

confidence: 99%

Consensus for Nonmelanoma Skin Cancer Treatment

Kauvar

Cronin

Roenigk

et al. 2015

Dermatologic Surgery

141

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Section: Epidemiologymentioning

confidence: 99%

Consensus for Nonmelanoma Skin Cancer Treatment

Kauvar

Cronin

Roenigk

et al. 2015

Dermatologic Surgery

141

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“…22 Also in tumor immunology studies, IFN-␥ is frequently employed to up-regulate MHC class I and II expression. 34,35 Therefore, immune privilege collapse in human scalp hair follicles was simulated by treating microdissected, organ-cultured anagen hair bulbs with IFN-␥. Organ culture of normal human scalp hair follicle, as pioneered by Philpott et al, 36 was chosen since this is readily available surplus material from plastic surgery and allows facile and well-controlled experimental manipulations in vitro.…”

mentioning

confidence: 99%

Collapse and Restoration of MHC Class-I-Dependent Immune Privilege

Ito

Bettermann

et al. 2004

The American Journal of Pathology

250

322

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The collapse of major histocompatiblity complex (MHC) class-I-dependent immune privilege can lead to autoimmune disease or fetal rejection. Pragmatic and instructive models are needed to clarify the as yet obscure controls of MHC class I down-regulation in situ, to dissect the principles of immune privilege generation, maintenance, and collapse as well as to develop more effective strategies for immune privilege restoration. Here, we propose that human scalp hair follicles, which are abundantly available and easily studied, are ideally suited for this purpose: interferon-␥ induces ectopic MHC class I expression in the constitutively MHC class-I-negative hair matrix epithelium of organ-cultured anagen hair bulbs, likely via interferon regulatory factor-1, along with up-regulation of the MHC class I pathway molecules ␤ 2 microglobulin and transporter associated with antigen processing (TAP-2). In the first report to identify natural immunomodulators capable of down-regulating MHC class I expression in situ in a normal, neuroectoderm-derived human tissue, we show that ectopic MHC class I expression in human anagen hair bulbs can be normalized by treatment with ␣-MSH, IGF-1, or TGF-␤1, all of which are locally generated, as well as by FK506. These agents are promising candidates for immune privilege restoration and for suppressing MHC class I expression where this is clinically desired (eg, in alopecia areata, multiple sclerosis, autoimmune uveitis, mumps orchitis, and fetal or allograft rejection). A select number of mammalian tissue sites, namely the brain, cornea, anterior chamber of the eye, testis, liver, fetotrophoblast, and the hamster cheek pouch, display a fascinating phenomenon called "immune privilege." [1][2][3][4][5] This name reflects that these tissue environments can award allotransplants relative protection from rejection by the host immune system.

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“…IL-10 is upregulated in both melanoma (13)(14)(15) and non-melanoma skin cancer including BCC (2,16,17). The presence of IL-10 in BCC is associated with the lack of expression of HLA-DR, ICAM-1, CD40 and CD80 and the inconsistent expression of HLA-ABC in BCC (17). BCC is regarded as an indolent (slow growing) cancer with limited metastatic potential.…”

Section: Il-10mentioning

confidence: 99%

The Role of Cytokines and Chemokines in the Development of Basal Cell Carcinoma

Itakura¹

2012

Basal Cell Carcinoma

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Interferon-?-induced ICAM-1 and CD40 expression, complete lack of HLA-DR and CD80 (B7.1), and inconsistent HLA-ABC expression in basal cell carcinoma: a possible role for interleukin-10?

Cited by 41 publications

References 26 publications

Consensus for Nonmelanoma Skin Cancer Treatment

Consensus for Nonmelanoma Skin Cancer Treatment

Collapse and Restoration of MHC Class-I-Dependent Immune Privilege

The Role of Cytokines and Chemokines in the Development of Basal Cell Carcinoma

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