Interferon, Nucleic Acid and Protein Synthesis in Mouse Spleen Cells after Acute  -Irradiation

Interferon Synthesis in Mouse Peritoneal Cells Damaged by X-Irradiation

“…Conflicting data, however, were obtained concerning the need of new DNA synthesis for interferon pro duction [11][12][13]. Our earlier observations indicated that the radioresistant cells are re sponsible for interferon production in irradiated animals and cell systems, as fractionated X-or gamma-irradiation (up to total doses of 2,000 R) or acute irradiation by protons of high energy did not inhibit the synthesis of circulat ing interferon induced by NDV, poly I:C or E.coli endotoxin [1,2,14,15], Moreover, in spleen cells of gamma-irradiated mice we have found that N DVinduced interferon is derived from radioresistant macrophages rather than from lymphocytes [3] in contrast to circulating interferon [4,16]. These results were recently confirmed by N a g a n o and M aehara [17].…”