Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) Type IV promoter by interferon regulatory factors 1 and 2

“…Both IRF-1 and IRF-2, as well as other IRF family members, exert their transcriptional regulatory activity through binding to the highly conserved interferonresponse element (IRF-E) found in the promoters of various IFN-inducible genes, including the genes for IFN-a/b (Fujita et al, 1988;Taniguchi et al, 1997), 2'-5'-OAS (Benech et al, 1987), GBP (Lew et al, 1991;Briken et al, 1995), iNOS (Xie et al, 1993;Spink and Evans, 1997), MHC class I (Blanar et al, 1989;Chang et al, 1992), TAP1 Min et al, 1996;White et al, 1996), IL-4 (Li-Weber et al, 1994), IL-6 (Faggioli et al, 1997), and IL-7 (Aragane et al, 1997). The IRF-E is also found in the promoters of three constitutively expressed genes: EBNA1 (Schaefer et al, 1997), histone H4 (Vaughan et al, 1995(Vaughan et al, , 1998, and murine muscle VCAM-1 (Jesse et al, 1998), which are activated by IRF-2.…”

Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis

“…IRF-1 induces IFN stimulated genes, e.g. MHC class I (Hobart et al, 1996;Salkowski et al, 1996), iNOS (Kamijo et al, 1994) and GBP (Briken et al, 1995). IRF-1 is also necessary for proper expression of IL-15 (Ogasawara et al, 1998), p21 (Tanaka et al, 1996), and IFN-b (Fujita et al, 1993).…”

IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo

“…Typical inducers are interferons, TNFa, IL-1, IL-6, dsRNA and viruses. IRF-1 induces IFN-stimulated genes such as those encoding MHC class I (Hobart et al, 1996;Salkowski et al, 1996), iNOS (Kamijo et al, 1994) and GBP (Briken et al, 1995). IRF-1 is also necessary for the proper expression of IL-15 (Ogasawara et al, 1998), p21 (Tanaka et al, 1996) and IFN-b (Matsuyama et al, 1993).…”