Interferon Sequence Homology and Receptor Binding Activity of Ovine Trophoblast Antiluteolytic Protein

Stewart, H. J.; McCann, S.H.E.; Barker, Paul D.; Lee, K.E.; Ge, Lan; Flint, Abbi

doi:10.1677/joe.0.115r013

Cited by 167 publications

(65 citation statements)

References 10 publications

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“…My entry into the field of interferon research was quite by chance and brought about by the unexpected discovery that the factor responsible for "rescuing" the corpus luteum (CL) during early pregnancy in sheep and cattle was a Type 1 interferon (IFN) (1)(2)(3). The CL is the normally transitory structure that develops on the ovary from the ruptured ovarian follicle following release of the oocyte and would normally regress if that oocyte failed to be fertilized and a pregnancy did not ensue.…”

Section: Introductionmentioning

confidence: 99%

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy

Roberts

2007

Cytokine & Growth Factor Reviews

109

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Interferon-τ is a major product of ovine and bovine conceptuses during the period before the trophoblast makes firm attachment to the uterine wall and begins to form a placenta. Its primary function is in preventing a return to ovarian cyclicity and hence ensuring the pregnancy continues, although it undoubtedly has other roles in ensuring receptivity of the maternal endometrium. Despite having properties similar to those of other Type 1, IFN-τ is not virally inducible and functions in a constitutive process unrelated to pathogenesis. The genes for IFN-τ (IFNT), which are confined to ruminant ungulate species, would appear to be the most recently evolved mammalian Type 1 gene family and are primarily under the transcriptional control of Ets2 and signal transduction pathways that target that transcription factor. The IFNT provide an illustration of how a gene control region can be commandeered and then refined to provide a radically changed pattern of expression.

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Section: Introductionmentioning

confidence: 99%

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy

Roberts

2007

Cytokine & Growth Factor Reviews

109

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“…The factors produced by the embryo to signal its presence vary considerably within different species, and in ruminants IFNτ, which has been shown to closely resemble the interferon-alpha family of antiviral proteins (Imakawa et al, 1987;Stewart et al, 1987;Stewart et al, 1989), especially the interferon alphas of class II (Charpigny et al, 1988;Charlier et al, 1989), is assumed to play a pivotal role in the context of maternal recognition of pregnancy. The trophoblast interferons were discovered in 1987 through the purification of ovine blastocyst secreted proteins with antiluteolytic properties.…”

Section: Maternal Recognition Of Pregnancy and The Pivotal Role Of Ifmentioning

confidence: 99%

“…The trophoblast interferons were discovered in 1987 through the purification of ovine blastocyst secreted proteins with antiluteolytic properties. Their biological function was assessed, among other assays, by administration into the uterus of cyclic sheep and cows, which resulted in the prolongation of the estrous cycle (Knickerbocker et al, 1986;Stewart et al, 1987;Vallet et al, 1988;Meyer et al, 1995). Despite its clear role as reproductive hormone, IFNτ has the typical antiviral, antiproliferative, and immunmodulatory activities of other type I IFNs, but unlike, it is not virally inducible (Roberts, 1996).…”

Section: Maternal Recognition Of Pregnancy and The Pivotal Role Of Ifmentioning

confidence: 99%

2 Identification of Genes Induced by the Conceptus in the Bovine Endometrium During the Pre-Implantation Period

Klein¹,

Bauersachs²,

Ulbrich³

et al. 2006

Reprod. Fertil. Dev.

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Early embryonic development, implantation, and maintenance of a pregnancy are critically dependent on an intact embryo-maternal communication. So far, only few signals involved in this dialogue have been identified. In ruminants, interferon tau (IFN�) plays a key role in the process of maternal recognition of pregnancy by exhibiting antiluteolytic activity. Even though many experimental findings indicate a pivotal role of IFN� in the context of embryo-maternal communication in ruminants, a number of other systems may be involved. To identify genes induced in the bovine endometrium by the signaling of the embryo, a combination of subtracted cDNA libraries and cDNA array hybridization was applied. Monozygotic twin pairs (n = 5) were used as the biological model. Pregnancy was created in one twin by transferring two in vitro-produced embryos on Day 7 of the estrous cycle; the other twin received a sham embryo transfer. Pregnant and nonpregnant twins were slaughtered at Day 18; endometrial tissue samples were recovered and processed for transcriptome analysis as described (Bauersachs et al. 2005 J. Mol. Endocrinol. 34, 889-908). Screening of 4608 clones of two subtracted libraries revealed 90 different up-regulated genes and mRNAs, of which almost 50% are known to be stimulated by type I interferons. Among these interferon-stimulated genes, the ISG15 system is assumed to be of particular interest, and several components were studied in more detail using in situ hybridization. The pattern of mRNA expression suggests that modification of endometrial proteins through ISG15ylation plays a fundamental role during the pre-implantation period. A classification of the identified genes based on Gene Ontologies revealed the prevalence of genes involved in regulation of gene expression, cell communication, cell growth, cell differentiation, cell proliferation, and cell adhesion, and also the prevalence of genes with immune-related functions. These results underline the intense response of the endometrium to the presence of a conceptus, culminating in the preparation of the maternal environment for embryonic implantation. Further, for eleven selected genes the expression in the endometrium was quantified by the use of real-time RT-PCR. Overall, the results of quantitative RT-PCR and array hybridization correlated very well. To our knowledge this study provides the first holistic gene expression analysis of the bovine endometrium during the pre-implantation period. The results underline the importance of IFN� as an embryo-derived pregnancy recognition signal and depict the molecular mechanisms at the mRNA level underlying the intense embryo-maternal dialog taking place at Day 18 of gestation.

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“…function (for review see Roberts, 1989). Recent studies provide evidence that oTP-1 and bTP-1 are structurally similar to interferons of the subclass (Imakawa et al, 1987Stewart et al, 1987;Charpigny et al, 1988). Both oTP-1 and bTP-1 have antiviral activity and oTP-1 can compete with interferon-, 1 for binding to interferon receptors in ovine endometrium (Stewart et al, 1987;Hansen et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Luteal function after intrauterine infusion of recombinant bovine interferon- I1 into postpartum beef cows expected to have short or normal luteal phases

Garverick¹,

Moser²,

Keisler³

et al. 1992

Reproduction

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Summary. This study was conducted to determine whether intrauterine infusion of recombinant bovine interferon-\g=a\I1(rboIFN-\g=a\I1), which has 70% sequence identity to bovine trophoblast protein-1, will prevent regression of corpora lutea anticipated to have a short lifespan.Twenty-six beef cows in good body condition were allotted to four treatment groups at parturition in a 2 \m=x\ 2 factorial design. Treatments were: group 1, saline; group 2, rboIFN-\g=a\I1;group 3, norgestomet\p=n-\saline; and group 4, norgestomet\p=n-\rboIFN\x=req-\ \g=a\I1.Norgestomet implants were inserted on days 21\p=n-\24 postpartum and removed 9 days later (before injection of human chorionic gonadotrophin (hCG) ). Ovulation was induced 30 to 33 days postpartum with 5000 or 10 000 iuhCG. Groups 1 (n = 7) and 3 (n = 5) were given intrauterine infusions (rectocervical approach) twice daily with saline on days 1\p=n-\12 or 13\p=n-\24 after hCG injection, respectively. Cows allotted to groups 2 (n = 8) and 4 (n = 6) were given intrauterine infusions (rectocervical approach) of 2 mg rboIFN-\g=a\I1 twice daily on days 1\p=n-\12 or 13\p=n-\24 after hCG injection, respectively.Treatment with both norgestomet and rboIFN-\g=a\I1delayed (P < 0\m=.\01)luteolysis.Lengths of luteal phases (days; mean \ m=+-\ sem) were 8\m=.\4\ m=+-\0\m=.\7 (group 1, saline), 12\m=.\1\ m=+-\ 1\m=.\0 (group 2, rboIFN-\g=a\I1), 18\m=.\6 \ m=+-\ 1\m=.\3 (group 3, norgestomet\p=n-\saline and 20\m=.\8\m=+-\1\ m=. \ 2 (group 4, norgestomet\p=n-\rboIFN-\g=a\I1). Concentration of progesterone in serum was similar among all groups the first 6 days following hCG-induced ovulation, but differed (P < 0\m=.\01) thereafter. Mean concentration of progesterone was lower (P < 0\m=.\01) in saline-treated cows (group 1) from days 8 to 13 than in cows infused with rboIFN-\g=a\I1 or pretreated with norgestomet. In summary, intrauterine infusion of rboIFN-\g=a\I1 delayed luteolysis of corpora lutea a n t i c i p a t e dto have a short lifespan.

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Interferon Sequence Homology and Receptor Binding Activity of Ovine Trophoblast Antiluteolytic Protein

Cited by 167 publications

References 10 publications

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy

2 Identification of Genes Induced by the Conceptus in the Bovine Endometrium During the Pre-Implantation Period

Luteal function after intrauterine infusion of recombinant bovine interferon- I1 into postpartum beef cows expected to have short or normal luteal phases

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