2006
DOI: 10.1111/j.1365-2567.2006.02518.x
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Interferon‐β therapy reduces CD4+ and CD8+ T‐cell reactivity in multiple sclerosis

Abstract: Summary Therapy with interferon‐β (IFN‐β) has well‐established clinical effects in multiple sclerosis (MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the prevalence and functional capacity of CD4+ and CD8+ T cells in healthy donors, and in untreated and IFN‐β‐treated MS patients, in response to myelin oligodendrocyte glycoprotein (MOG). The proportion of CD45RO+ memory T cells was higher in MS patients than in healthy donors, but returned to normal values upon therapy with IF… Show more

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Cited by 33 publications
(20 citation statements)
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“…, Table ) that corresponds to the results of other authors . rMOG was used as in vitro potential target autoantigen and as the most immunogenic and acceptable protein for assessing the intensity of cellular and humoral reactions in MS according to our previous data . According to this study, inhibitory effects of allogeneic as well as autologous MSC from patients with MS on myelin‐specific T cell proliferation were more expressed as compared to the analysed data in healthy donors (Fig.…”
Section: Discussionsupporting
confidence: 74%
“…, Table ) that corresponds to the results of other authors . rMOG was used as in vitro potential target autoantigen and as the most immunogenic and acceptable protein for assessing the intensity of cellular and humoral reactions in MS according to our previous data . According to this study, inhibitory effects of allogeneic as well as autologous MSC from patients with MS on myelin‐specific T cell proliferation were more expressed as compared to the analysed data in healthy donors (Fig.…”
Section: Discussionsupporting
confidence: 74%
“…Treatment of MS patients with IFN-β is shown to reduce the frequency of VLA4 + CD8 + T cells among total PBMCs, as well as VLA4 surface expression [44]. Similar results were obtained upon MOG stimulation of PBMCs from IFN-β-treated MS patients, where decreased frequencies of CD8 + and CD8 + IFN-γ + T cells were observed [91].…”
Section: Cd8 + T Cellssupporting
confidence: 84%
“…CD8 + T cells specific for myelin antigens are also pathogenic in various EAE models (19)(20)(21)(22)(23). Prior efforts to study myelinspecific CD8 + T cells have been hampered by technical limitations and reliance on in vitro manipulation (24)(25)(26)(27)(28)(29)(30). In this study, we employed pMHC I tetramer-based methods to unambiguously identify myelin-specific CD8 + T cell populations directly from the peripheral blood without in vitro stimulation or manipulation.…”
Section: Discussionmentioning
confidence: 99%
“…Myelin is considered a putative target autoantigen in MS (18), and myelin-specific CD8 + T cells are well known to contribute to CNS pathology in experimental autoimmune encephalomyelitis (EAE) (19)(20)(21)(22)(23). A number of studies have described the reactivity of human CD8 + T cells against myelin antigens (24)(25)(26)(27)(28)(29)(30); however, reports are conflicting whether myelin-specific CD8 + T cell responses differ between MS patients and controls (24,(27)(28)(29)(30). Much of the prior work was limited by a reliance on functional assays, precluding the sensitive detection of unmanipulated epitopespecific CD8 + T cell populations.…”
mentioning
confidence: 99%