Interferon γ, IL-17, and IL-1β impair sperm motility and viability and induce sperm apoptosis

Paira, Daniela Andrea; Silvera-Ruiz, Silene M.; Tissera, Andrea; Molina, Rosa Isabel; Olmedo, José Javier Serrano; Rivero, Virginia; Motrich, Rubén Darío

doi:10.1016/j.cyto.2022.155834

Cited by 25 publications

(10 citation statements)

References 53 publications

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“…Besides promoting oxidative damage primarily to the sperm membranes via lipid peroxidation [ 76 ], it has been postulated that these molecules participate in the induction of cell death. Within the vast array of pro-inflammatory cytokines, TNF-α and IFN-γ, which are the predominant molecules secreted during infection and/or inflammation, may trigger sperm phosphatidylserine translocation or DNA fragmentation [ 77 , 78 ]. Among interleukins, IL-1 and IL-6 also seem to mediate damage to male gametes, which agrees with our observations on their increasing levels in proportion to a diminished semen quality following a longer abstinence interval.…”

Section: Discussionmentioning

confidence: 99%

Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men—How Does the Seminal Bacteriome Respond?

Tvrdá

Ďuračka

Benko

et al. 2023

IJMS

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This study was designed to describe bacterial profiles of ejaculates collected following a long and short ejaculatory abstinence set in the context of changes in the conventional, oxidative, and immunological characteristics of semen. Two specimens were collected in succession from normozoospermic men (n = 51) following 2 days and 2 h, respectively. Semen samples were processed and analyzed according to the World Health Organization (WHO) 2021 guidelines. Afterwards, sperm DNA fragmentation, mitochondrial function, levels of reactive oxygen species (ROS), total antioxidant capacity, and oxidative damage to sperm lipids and proteins were evaluated in each specimen. Selected cytokine levels were quantified using the ELISA method. Bacterial identification by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry revealed that samples collected following two days of abstinence presented with a higher bacterial load and diversity, and a greater prevalence of potentially uropathogenic bacteria including Escherichia coli, Staphylococcus aureus and Enterococcus faecalis. Only staphylococci and Escherichia coli remained present in specimens obtained after 2 h of abstinence. Whilst all samples accomplished the criteria set by WHO, a significantly higher motility (p < 0.05), membrane integrity (p < 0.05), mitochondrial membrane potential (p < 0.05), and DNA integrity (p < 0.0001) were detected following 2 h of ejaculatory abstinence. On the other hand, significantly higher ROS levels (p < 0.001), protein oxidation (p < 0.001), and lipid peroxidation (p < 0.01) accompanied by significantly higher concentrations of tumor necrosis factor alpha (p < 0.05), interleukin-6 (p < 0.01), and interferon gamma (p < 0.05) were observed in specimens collected after two days of abstinence. It may be summarized that shorter ejaculatory abstinence does not compromise sperm quality in normozoospermic men, while it contributes to a decreased occurrence of bacteria in semen which is accompanied by a lower probability of damage to spermatozoa by ROS or pro-inflammatory cytokines.

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Section: Discussionmentioning

confidence: 99%

Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men—How Does the Seminal Bacteriome Respond?

Tvrdá

Ďuračka

Benko

et al. 2023

IJMS

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“…Importantly, inflammatory cytokines recruit and activate leukocytes, which results in increased ROS production 29 . Previous studies have reported that sperm quality was decreased, especially low sperm motility, after incubation of spermatozoa with several cytokines, including IL‐6, TNF‐α, IFN‐γ, IL‐17A, and IL‐1β 30–32 . Thus, inflammatory cytokines released by leukocytes may lead to an inflammatory response resulting in poor semen quality.…”

Section: Discussionmentioning

confidence: 99%

Effect of leukocytes on semen quality in men from primary and secondary infertile couples: A cross‐sectional study

Fan,

Zhao,

Zhang

et al. 2023

Health Science Reports

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Background and AimsLeukocytospermia (LCS) is a known cause of male infertility. However, the relationship between seminal leukocytes and semen quality among infertile couples remains controversial. This study aims to investigate the association between semen quality and LCS in male partners of infertile couples.MethodsSemen samples were collected from 512 men who asked for a fertility evaluation in a reproductive center in China. Seminal leukocytes were counted following peroxidase staining with benzidine. Other semen parameters were compared in subfertile men with and without LCS.ResultsPoor semen quality (e.g., low semen volume, sperm concentration, and sperm progressive/total motility) was observed among men with LCS compared to those without LCS. Men with LCS had a higher risk of low sperm progressive motility (OR = 0.99, 95% CI = 0.98−0.99, p = 0.02) and total motility (OR = 0.99, 95% CI = 0.98−0.99, p = 0.02), even after adjustment for potential confounders (both OR = 0.99, 95% CI = 0.98−0.99, p = 0.03). Lower sperm viability was observed in LCS from male partners of secondary couples, while no significant difference in semen parameters was found between men with and without LCS in male partners of primary infertile couples. Low sperm motility and viability were associated with LCS in men from secondary infertile couples after adjusting for confounders (OR = 0.97, 95% CI = 0.95−0.99, p = 0.04; OR = 0.94, 95% CI = 0.89−0.99, p = 0.04, respectively).ConclusionsOur findings indicate that a higher risk of abnormal semen parameters was correlated with an increased number of leukocytes in men from secondary infertile couples.

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“…IL-17 is a driver of immunopathology in asthma, 259 COPD, 260 neurodegenerative diseases, 261 autoimmune diseases, [262][263][264] or infertility. 265,266 IL-33 has also been involved in some of these diseases, but often in animal models. 262,267,268 It is possible that changes in the microbiome are modifying the protective effects of IL-17 or its interaction with IL-33, and that genetic variations of IL33 or IL17 genes associated with environmental influences may confer protective or susceptibility risk in the onset of the disease.…”

Section: Chronic Diseases Autoimmunity and Mental Healthmentioning

confidence: 99%

“…The IL‐33‐IL‐17 interplay in rhinitis and asthma may be extended to other diseases. IL‐17 is a driver of immunopathology in asthma, 259 COPD, 260 neurodegenerative diseases, 261 autoimmune diseases, 262–264 or infertility 265,266 . IL‐33 has also been involved in some of these diseases, but often in animal models 262,267,268 …”

Section: “One‐airway‐one‐disease” Disentangled Refined and Beyondmentioning

confidence: 99%

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Bousquet

Melén

Haahtela

et al. 2023

Allergy

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Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper-and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper-and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

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Interferon γ, IL-17, and IL-1β impair sperm motility and viability and induce sperm apoptosis

Cited by 25 publications

References 53 publications

Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men—How Does the Seminal Bacteriome Respond?

Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men—How Does the Seminal Bacteriome Respond?

Effect of leukocytes on semen quality in men from primary and secondary infertile couples: A cross‐sectional study

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

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