Interferon-γ is expressed in both gut and spleen during<i>Eimeria tenella</i>infection

Rothwell, Lisa; Muir, W. I.; Kaiser, Pete

doi:10.1080/03079450050118467

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…Cytokines synthesized and secreted by leukocytes play important regulatory roles during the immune response to infection. In avian coccidiosis, it was clear that IFN-γ was produced by the host at sites of infection (Rothwell et al 2000;Yun et al 2000), and IFN-γ release has been used to screen for protective antigens against E. tenella infections (Breed et al 1999). In this report, IFN-γ levels in the serum samples were significantly higher when compared with those of the PBS group (p<0.05).…”

Section: Discussionmentioning

confidence: 42%

Efficacy of Eimeria tenella rhomboid-like protein as a subunit vaccine in protective immunity against homologous challenge

Zheng

Gong

et al. 2011

Parasitol Res

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The immune responses and protective efficacy against homologous challenge in chickens elicited by recombinant proteins of a rhomboid-like gene (ETRHO1) from Eimeria tenella was investigated in the present study. When chickens were immunized with the recombinant rhomboid antigen, specific antibody was generated by ELISA assay. In comparison with the PBS group, the expression levels of interleukin-2, interferon-γ, as well as the percentages of CD4⁺ and CD8⁺ cells in the group immunized with the recombinant rhomboid proteins were significantly increased (p < 0.01, p < 0.05, and p < 0.05, respectively). These results suggest that rhomboid was capable of eliciting humoral and cell-mediated immunity response in birds. Challenge experiments demonstrated that the recombinant rhomboid protein could provide chickens with a protection rate around 77.3%. Numbers of oocysts and cecal lesion from chickens in the group immunized with recombinant rhomboid proteins decreased significantly, and the body weight increased significantly when compared with chickens in the PBS group (p < 0.05). These results suggested that the recombinant rhomboid antigen was able to impart partial protection against homologous challenge in chicken and could be a potential candidate for an E. tenella vaccine development.

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Section: Discussionmentioning

confidence: 42%

Efficacy of Eimeria tenella rhomboid-like protein as a subunit vaccine in protective immunity against homologous challenge

Zheng

Gong

et al. 2011

Parasitol Res

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“…Lee et al (2011Lee et al ( , 2012 indicated that antibodies and thus Th2 response also play a role in C. perfringens defense. Regarding Eimeria, IFN-c up-regulation was also seen before in the intestine (Laurent et al, 2001) and the spleen (Rothwell et al, 2000) of first-time E. tenella infected chickens. Rothwell et al (2000) did not observe this effect in previously immunised chickens which complies with the findings of the present study.…”

Section: Discussionmentioning

confidence: 81%

Efficacy of an anticoccidial live vaccine in prevention of necrotic enteritis in chickens

Bangoura¹,

Alnassan²,

Lendner³

et al. 2014

Experimental Parasitology

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“…In avian coccidiosis, it is clear that IFN-␥ is produced by the host at sites of infection (78,112), and IFN-␥ release has been used as a measure of the T-cell response to coccidial antigens (68,73). Treatment of coccidia-infected chickens with recombinant chicken IFN-␥ (89) improved weight gains with respect to uninfected controls (55,64).…”

Section: Immunobiologymentioning

confidence: 99%

Recent Advances in Biology and Immunobiology ofEimeriaSpecies and in Diagnosis and Control of Infection with These Coccidian Parasites of Poultry

2002

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SUMMARY Avian coccidiosis, an intestinal disease caused by protozoan parasites of the genus Eimeria, occurs worldwide. It is considered to be one of the most economically important diseases of domestic poultry. For many years, prophylactic use of anticoccidial feed additives has been the primary means of controlling coccidiosis in the broiler industry and has played a major role in the growth of this industry, which now can produce about 7.6 billion chickens annually. However, development of anticoccidial resistance has threatened the economic stability of the broiler industry. Although there has been little effort by the pharmaceutical industry to develop new anticoccidials, the mounting problem of drug resistance of Eimeria species has prompted major research efforts to seek alternative means of control through increased knowledge of parasite biology, host response, and nutritional modulation. As a consequence, important advancements have been made, particularly in defining parasite antigens that have potential use in vaccines, defining the Eimeria genome, understanding the immunology of coccidial infections, and the practical applications of live vaccines. This review describes the progress in these areas, most of which has occurred within the past 10 to 15 years.

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Interferon-γ is expressed in both gut and spleen duringEimeria tenellainfection

Cited by 19 publications

References 31 publications

Efficacy of Eimeria tenella rhomboid-like protein as a subunit vaccine in protective immunity against homologous challenge

Efficacy of Eimeria tenella rhomboid-like protein as a subunit vaccine in protective immunity against homologous challenge

Efficacy of an anticoccidial live vaccine in prevention of necrotic enteritis in chickens

Recent Advances in Biology and Immunobiology ofEimeriaSpecies and in Diagnosis and Control of Infection with These Coccidian Parasites of Poultry

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