2022
DOI: 10.22541/au.166785827.71438961/v1
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Intergenerational Arsenic Exposure on the Mouse Epigenome and Metabolic Physiology

Abstract: Inorganic Arsenic (iAs) is one of the largest toxic exposures to impact humanity worldwide. Exposure to iAs during pregnancy may disrupt the proper remodeling of the epigenome of F1 developing offspring and potentially their F2 grand-offspring via disruption of fetal primordial germ cells (PGCs). There is a limited understanding between the correlation of disease phenotype and methylation profile within offspring of both generations and whether it persists to adulthood. Our study aims to understand the interge… Show more

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