Interictal 18F-FDG brain PET metabolism in patients with postictal EEG suppression

McGonigal, Aileen; Youssef, Nada El; Bartolomei, Fabricē; Giusiano, Bernard; Guedj, Éric

doi:10.1016/j.yebeh.2020.107742

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…Their result could suggest that possible interictal metabolic disruption in the temporal pole within a right-sided cortico-subcortical network. 43 We speculate that the reduced CBF or less metabolically active in right temporal pole may reflect the most notable feature of interictal brain metabolic changes.…”

Section: Discussionmentioning

confidence: 82%

Altered Cerebral Blood Flow is Linked to Disease Duration in Patients with Generalized tonic‒clonic Seizures

Li¹,

Niu²,

Qiu³

et al. 2022

NDT

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To investigate cerebral blood flow (CBF) characteristics in individuals with generalized tonic-clonic seizures (GTCS) during the interictal phase using voxel-based analysis of 3D pseudocontinuous arterial spin labeling (PCASL). Patients and Methods: Patients with GTCS (GTCS group) (during the interictal period) and healthy volunteers (control group) underwent head MR imaging with a 3.0T MR scanner with a 3D PCASL sequence. CBF was compared between the two groups. Spearman correlations of CBF in regions of interest (ROIs) in GTCS patients with the duration of disease and age of onset were analyzed and corrected using the false discovery rate (FDR). Results: Twenty patients with GTCS (GTCS group) and twenty healthy volunteers (control group) were recruited for this study. On 3D PCASL, (1) GTCS patients had lower CBF in the brainstem, right cerebellum, right inferior temporal gyrus, parahippocampal gyrus, superior frontal gyrus, middle frontal gyrus, triangular part of inferior frontal gyrus, left temporal pole of superior temporal gyrus and thalamus and had higher CBF in the bilateral superior parietal gyri, precuneus, precentral gyri, postcentral gyri, and left dorsolateral superior frontal gyrus than controls. (2) The CBF of the right temporal pole of the middle temporal gyrus was negatively correlated with the duration of disease (P FDRcorrected <0.05), with a correlation coefficient r of −0.7333 and a P FDRcorrected value of 0.04. Conclusion:Voxel-based analysis of 3D PCASL imaging can be used to sensitively detect brain perfusion differences in GTCS patients. The decrease in CBF in the right temporal pole of the middle temporal gyrus may be associated with disease onset. These findings may offer new perspectives on the pathogenesis of GTCS and the underlying pathophysiological changes associated with perfusion.

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Section: Discussionmentioning

confidence: 82%

Altered Cerebral Blood Flow is Linked to Disease Duration in Patients with Generalized tonic‒clonic Seizures

Li¹,

Niu²,

Qiu³

et al. 2022

NDT

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“…Consistent with our results, a recent FDG PET study proposed a cortico-subcortical metabolic network abnormality. They also found that hypometabolism in temporal regions, mainly in the right hemisphere, has been related to widespread postictal suppression in epilepsy patients with a history of BTCS [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a study of patients with severe ictal-hypoxia during generalized seizures, lower volumes in the temporal pole and right superior temporal gyrus were detected [ 11 ]. Cortical thinning, including progressive atrophy using MRI, has been seen in superior temporal gyrus in epilepsy patients [ 57 , 58 ]. Concerning autonomic function, the parahippocampal gyrus in addition to other mesial temporal regions have direct connections to brainstem autonomic regulatory nuclei [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Relation of Brain Perfusion Patterns to Sudden Unexpected Death Risk Stratification: A Study in Drug Resistant Focal Epilepsy

Chacón

García

Bosch-Bayard

et al. 2022

Behavioral Sciences

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To explore the role of the interictal and ictal SPECT to identity functional neuroimaging biomarkers for SUDEP risk stratification in patients with drug-resistant focal epilepsy (DRFE). Twenty-nine interictal-ictal Single photon emission computed tomography (SPECT) scans were obtained from nine DRFE patients. A methodology for the relative quantification of cerebral blood flow of 74 cortical and sub-cortical structures was employed. The optimal number of clusters (K) was estimated using a modified v-fold cross-validation for the use of K means algorithm. The two regions of interest (ROIs) that represent the hypoperfused and hyperperfused areas were identified. To select the structures related to the SUDEP-7 inventory score, a data mining method that computes an automatic feature selection was used. During the interictal and ictal state, the hyperperfused ROIs in the largest part of patients were the bilateral rectus gyrus, putamen as well as globus pallidus ipsilateral to the seizure onset zone. The hypoperfused ROIs included the red nucleus, substantia nigra, medulla, and entorhinal area. The findings indicated that the nearly invariability in the perfusion pattern during the interictal to ictal transition observed in the ipsi-lateral putamen F = 12.60, p = 0.03, entorhinal area F = 25.80, p = 0.01, and temporal middle gyrus F = 12.60, p = 0.03 is a potential biomarker of SUDEP risk. The results presented in this paper allowed identifying hypo- and hyperperfused brain regions during the ictal and interictal state potentially related to SUDEP risk stratification.

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“…Recently, FDG PET hypometabolism of the right hemisphere and most notable in temporal regions have been associated with widespread postictal suppression in patients with epilepsy [34]. Patients were also found to have a history of BTCS (therefore having increased SUDEP risk).…”

Section: Discussionmentioning

confidence: 99%

Frontal lobe hypometabolism associated with Sudden Unexpected Death in Epilepsy (SUDEP) risk: An objective PET study

Kumar

Alhourani

Abdelkader

et al. 2021

Epilepsy & Behavior

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Interictal 18F-FDG brain PET metabolism in patients with postictal EEG suppression

Cited by 7 publications

References 35 publications

Altered Cerebral Blood Flow is Linked to Disease Duration in Patients with Generalized tonic‒clonic Seizures

Altered Cerebral Blood Flow is Linked to Disease Duration in Patients with Generalized tonic‒clonic Seizures

Relation of Brain Perfusion Patterns to Sudden Unexpected Death Risk Stratification: A Study in Drug Resistant Focal Epilepsy

Frontal lobe hypometabolism associated with Sudden Unexpected Death in Epilepsy (SUDEP) risk: An objective PET study

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