Interictal Epileptiform Discharge Detection in EEG in Different Practice Settings

Halford, Jonathan J.; Westover, M. Brandon; LaRoche, Suzette M.; Macken, Mícheál P.; Kutluay, Ekrem; Edwards, Jonathan; Leonardo, Bonilha; Kalamangalam, Giridhar P.; Ding, Kan; Hopp, Jennifer L.; Arain, Amir; Dawson, Rachael A.; Martz, Gabriel U.; Wolf, Bethany J.; Waters, Chad G.; Dean, Brian C.

doi:10.1097/wnp.0000000000000492

Cited by 29 publications

(30 citation statements)

References 20 publications

(28 reference statements)

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“…33,41,42 The Persyst algorithm, although validated, has been previously associated with a high rate of false positives. 43 In its validation study, the SpikeNet algorithm was directly compared to neurophysiology-trained experts and Persyst, exceeding both in performance. 34 Here, we detected a possible relationship between spike rate and CI in hemispheres with active spikes using SpikeNet, although this possible finding requires validation in a second dataset.…”

Section: F I G U R Ementioning

confidence: 99%

Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes

et al. 2020

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Objective: Childhood epilepsy with centrotemporal spikes (CECTS) is a common, focal, transient, developmental epilepsy syndrome characterized by unilateral or bilateral, independent epileptiform spikes in the Rolandic regions of unknown etiology. Given that CECTS presents during a period of dramatic white matter maturation and thatspikes in CECTS are activated during non-rapid eye movement (REM) sleep, we hypothesized that children with CECTS would have aberrant development of white matter connectivity between the thalamus and the Rolandic cortex. We further tested whether Rolandic thalamocortical structural connectivity correlates with spike rate during non-REM sleep. Methods: Twenty-three children with CECTS (age = 8-15 years) and 19 controls (age = 7-15 years) underwent 3-T structural and diffusion-weighted magnetic resonance imaging and 72-electrode electroencephalographic recordings. Thalamocortical structural connectivity to Rolandic and non-Rolandic cortices was quantified using probabilistic tractography. Developmental changes in connectivity were compared between groups using bootstrap analyses. Longitudinal analysis was performed in four subjects with 1-year follow-up data. Spike rate was quantified during non-REM sleep using manual and automated techniques and compared to Rolandic connectivity using regression analyses. Results: Children with CECTS had aberrant development of thalamocortical connectivity to the Rolandic cortex compared to controls (P = .01), where the expected increase in connectivity with age was not observed in CECTS. There was no difference in the development of thalamocortical connectivity to non-Rolandic regions between CECTS subjects and controls (P = .19). Subjects with CECTS observed longitudinally had reductions in thalamocortical connectivity to the Rolandic cortex over time. No definite relationship was found between Rolandic connectivity and non-REM spike rate (P > .05). Significance: These data provide evidence that abnormal maturation of thalamocortical white matter circuits to the Rolandic cortex is a feature of CECTS. Our data How to cite this article: Thorn EL, Ostrowski LM, Chinappen DM, et al. Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes.

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Section: F I G U R Ementioning

confidence: 99%

Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes

et al. 2020

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“…Nevertheless, studies dating back several decades have reported interreader agreement on EEG findings ranging from poor to substantial but have been generally limited by factors including small EEG sample size, potentially biased selection of EEG samples (either too easy or to complex), and small numbers of readers from single centers. 1,4,5 Factors that have been correlated with improved interrater agreement for IEDs include fellowship EEG training, subspecialty board certification, academic versus private practice, and greater time devoted to EEG reading. 1,5 However, a recent study found that even expert readers with high confidence in their interpretation were often not in agreement with their peers.…”

Section: Commentarymentioning

confidence: 99%

“…1,4,5 Factors that have been correlated with improved interrater agreement for IEDs include fellowship EEG training, subspecialty board certification, academic versus private practice, and greater time devoted to EEG reading. 1,5 However, a recent study found that even expert readers with high confidence in their interpretation were often not in agreement with their peers. 6 Therefore, despite the widespread use of EEG, one could still reasonably argue the reliability of an interpretation regardless of the qualifications of the reader.…”

Section: Commentarymentioning

confidence: 99%

Most Experts Agree … But What About Other EEG Readers?

Noe¹

2020

Epilepsy Curr

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“…Andererseits können auch bei qualifizierten und erfahrenen EEG-Befundern beträchtliche interindividuelle Diskrepanzen in der Zuordnung von ETPs bestehen [9][10][11]. Die Übereinstimmung von zertifizieren EEG-Befundern in akademischen Institutionen mit einer EEG-Spezialausbildung ist dabei größer als die von niedergelassenen EEG-Befundern ohne Zusatzqualifikation [9,10].…”

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Automatische Erkennung von epilepsietypischen Potenzialen und Anfällen im EEG

Baumgartner¹,

Häfner²,

Koren³

2020

Klinische Neurophysiologie

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Die Elektroenzephalografie (EEG) ist der wichtigste apparative Eckpfeiler in der Diagnostik und Therapieführung bei Epilepsien. Die visuelle EEG-Befundung stellt dabei nach wie vor den Goldstandard dar. Automatische computerunterstützte Methoden zur Detektion und Quantifizierung von interiktalen epilepsietypischen Potenzialen und Anfällen unterstützen eine zeitsparende, objektive, rasch und jederzeit verfügbare quantitative EEG-Befundung.

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Interictal Epileptiform Discharge Detection in EEG in Different Practice Settings

Cited by 29 publications

References 20 publications

Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes

Persistent abnormalities in Rolandic thalamocortical white matter circuits in childhood epilepsy with centrotemporal spikes

Most Experts Agree … But What About Other EEG Readers?

Automatische Erkennung von epilepsietypischen Potenzialen und Anfällen im EEG

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