Interleukin-1 as a Key Factor in the Development of Inflammatory Diseases

Abstract

Context: High levels of interleukin-1 have been implicated in uncontrolled inflammation and fever in inflammatory diseases, including; familial Mediterranean fever, cryopyrin associated periodic syndrome, Behcet's disease and systemic onset juvenile idiopathic arthritis. The underlying specific genetic causes for these diseases have not yet been elucidated due to inferring factors, such as high levels of interleukin-1 beta (IL-1β) in the blood and etiology, as well as the disease manifestations. Conclusions: This review discusses the role of interleukin-1 beta and interleukin-18 production pathways in the development of systemic onset juvenile idiopathic arthritis and familial Mediterranean fever disease. Keywords: Autoimmune Diseases; Interleukin 1 Receptor Antagonist Protein; CytokinesImplication for health policy/practice/research/medical education: High levels of interleukin-1 have been implicated in uncontrolled inflammation and fever in inflammatory diseases.

Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review

“…A significant positive association between the serum cystatin C and periodontal disease was found in one study. These results supported a previous study showing that the level of cystatin C could be used as a marker in chronic periodontitis [ 41 , 69 ]. In addition, increased levels of cystatin C are associated with decreased kidney function, meaning that in the presence of both diseases (periodontitis and CKD), cystatin C was higher, and this can lead to the worst periodontal condition and kidney function [ 70 ].…”

Treatment of Colchicine-Resistant Familial Mediterranean Fever With Anakinra

“…Mutations in this gene result defective FMF pyrin production that leads to defective apoptosis and stimulates IL1 processing, and production of active IL-1β, which eventually leads to the uncontrolled inflammation (18). The role of IL-1β in the pathogenesis of the disease is the reason to use anakinra to treat FMF (19,20). Anakinra is a recombinant form of interlukin-1 receptor antagonist (IL-1Ra).…”

Phytochemical Composition, Anti-Inflammatory and Cytotoxic Activities of Chloroform Extract of <i>Senna crotalarioides</i> Kunth

“…IL-1β is also a mediator of inflammatory response and exacerbates damage during chronic and acute tissue injury [12].…”