Interleukin-1 Beta Gene Polymorphism rs16944 May Associate with Increased Susceptibility to Extremity Chronic Osteomyelitis in Chinese Han Population

Abstract

Background. Previous studies had indicated that interleukin-1 beta (IL-1β) gene single nucleotide polymorphisms (SNPs) associate with different inflammatory diseases. However, potential links between these polymorphisms and susceptibility to extremity chronic osteomyelitis (COM) remain unclear. This study aimed to investigate relationships between IL-1β gene polymorphisms (rs16944, rs1143627, rs1143634, and rs2853550) and risks of developing extremity COM in Chinese Han population. Methods. Altogether 233 extremity COM patients and 200 healthy controls were genotyped for the four tag SNPs of the IL-1β gene using the SNapShot genotyping method. Comparisons were performed regarding genotype distribution, mutant allele frequency, and four genetic models (dominant, recessive, homozygous, and heterozygous models) of the four SNPs between the two groups. Results. Significant associations were identified between rs16944 polymorphism and the risk of developing COM by dominant model (P = 0.026, OR = 1.698, 95% CI 1.065-2.707) and heterozygous model (P = 0.030, OR = 1.733, 95% CI 1.055-2.847). Although no statistical differences were found of rs1143627 polymorphism between the two groups, there existed a trend that rs1143627 may be linked to an elevated risk of developing COM by outcomes of dominant (P = 0.061), homozygous (P = 0.080) and heterozygous (P = 0.095) models. However, no statistical correlations were found between rs1143634 and rs2853550 polymorphisms and susceptibility to COM in Chinese Han population. Conclusions. To our knowledge, we reported for the first time that IL-1β gene rs16944 polymorphism may contribute to the increased susceptibility to extremity COM in Chinese Han population, with genotype of AG as a risk factor.

Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

“…First, we found that IL-1β gene rs16944 correlates with an increased risk of PTOM development, with AG and GG genotypes as risk factors. The present outcomes share both similarities and differences with previous studies [8,20,21]. We agree with the previous conclusions that rs16944 is a risk factor of OM, regardless of OM etiology (trauma, hematogenous spread) and population (Chinese, Saudi, and Brazilian).…”

“…Second, we found that IL-1β gene rs1143627 also associates with an elevated susceptibility to PTOM, with TT genotype as a risk factor. While in the previous study [20], we failed to obtain any significant links between the two, which is probably because of the inclusion of the non-PTOM patients. Although no statistical differences were identified regarding the genotype distribution, mutant allele frequency, or the heterozygous model between the two groups, their P values were close to 0.05, implying that the mutant allele T may be a risk factor and population with CT genotype may be in a higher risk to develop PTOM.…”

“…However, the genotype distributions differed among different investigations, which are probably influenced by OM etiology, ethnicity, and the sample size as well. Although our previous study [20] had reported that rs16944 associates with an increased risk of developing chronic OM, we recruited patients with different causes of chronic OM (infection following trauma and orthopaedic surgery, hematogenous spread, and diabetic foot). Therefore, there may exist a risk of bias.…”

Systemic lupus erythematosus Association between Osteomyelitis: A two-sample Mendelian randomization study in European population

“…A burgeoning body of evidence underscores the potential role of genetic variants, specifically single nucleotide polymorphisms (SNPs), in shaping the susceptibility to OM. Noteworthy instances include genetic variants at loci such as Bax-Gene G (-248) (rs4645878), IFN-γ (rs2430561), IL-1β (rs1143634), and TLR-2 (rs3804099), which have demonstrated associations with heightened vulnerability to hematogenous or traumatic OM across diverse ethnic cohorts [ [5] , [6] , [7] ].…”

The relationship between gestational diabetes mellitus and interleukin 1beta gene polymorphisms in southwest of China

“…[ 5 ] Furthermore, IL1B polymorphism rs16944 is associated with multiple inflammatory diseases such as chronic periodontitis, coronary artery lesions and chronic osteomyelitis. [ 8 – 10 ] Therefore, it is conceivable that IL1B polymorphism rs1143623 and rs16944 potentially have the closely related to inflammatory diseases, such as GDM.…”