Interleukin-1 gene cluster polymorphisms in cerebral infarction

Um, Jae‐Young; Moon, Kyung-Suk; Lee, Kang‐Min; Kim, Hyung-Min

doi:10.1016/s1043-4666(03)00183-2

Cited by 22 publications

(22 citation statements)

References 43 publications

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“…29 Furthermore, studies of the IL-1 and IL-1RA genes suggest that polymorphisms in both IL-1a and IL-1RA genes may be associated with increased risk of stroke. [30][31][32] Similarly, TNF-a has been hypothesized to play an important role in neurodegeneration. 33 TNF-a release from blood cells and serum levels of TNF-a were found to be elevated during the acute phase following stroke compared with healthy controls.…”

Section: Resultsmentioning

confidence: 99%

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

et al. 2006

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Although poststroke depression is unlikely to represent a single disorder and numerous etiologies for different kinds of poststroke depression will likely emerge as the result of future research, we believe that a number of poststroke depressive disorders are likely to be the result of specific changes in brain pathology and neurophysiology. Nevertheless, there are relatively few hypotheses about the pathophysiology of poststroke depression. This paper, therefore, proposes a new hypothesis for poststroke depression involving increased production of proinflammatory cytokines resulting from brain ischemia in cerebral areas linked to the pathogenesis of mood disorders. This paper reviews the evidence supporting the hypothesis that proinflammatory cytokines are involved in the occurrence of stroke as well as mood disorders linked to the brain damage. The increased production of proinflammatory cytokines such as IL-1b, TNF-a or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia. The resultant physiological dysfunction may lead to poststroke depression. Future investigations may explore this hypothesis through more extensive studies on the role of proinflammatory cytokines, such as IL-1b, TNF-a or even IL-18, in patients with poststroke depression. Molecular Psychiatry (2006) 11, 984-991.

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Section: Resultsmentioning

confidence: 99%

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

et al. 2006

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“…The variant allele T at -889 was significantly associated with CAD. The same IL-1A-889T allele has previously been associated with cardiovascular diseases such as cerebral infarction [14][15] and stroke. 13 Published studies on the IL-1A-889 C/T polymorphism in CAD 16,19 have reported conflicting results, making it difficult to establish whether this single-nucleotide polymorphism (SNP) is an independent risk factor for CAD.…”

Section: Discussionmentioning

confidence: 82%

“…11 Some studies [14][15] support the association of IL1-A-889 C/T polymorphism with stroke [12][13] and cerebral infarction, [14][15] whereas others 11,16 failed to demonstrate a significant link with the disease. To our knowledge, there are no reported data regarding IL-1A -889 C/T polymorphism and familial CAD.…”

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confidence: 99%

Heritability ofIL-1AGene Promoter Polymorphism in Patients With Coronary Artery Disease: A Trio-Family Study

Haroon

Hussain

Javed

2015

Lab Med

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“…21 Similar interactions between the IL-1ra and IL-1␣ genotypes have been observed in ischemic stroke. 22 Variations in IL1RN and other related genes may have other effects such as lowering the threshold for susceptibility for ischemic stroke. 23 Chlamydial infection may confer greater risk for symptomatic atherosclerotic disease among carriers of IL1RN and IL1B gene mutations out of proportion to the risk conferred by either these mutations or the infection alone; 24 not all data support this association.…”

Section: Discussionmentioning

confidence: 99%

IL1RN VNTR Polymorphism in Ischemic Stroke

Worrall

Brott

Brown

et al. 2007

Stroke

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for the SWISS, ISGS, and MSGD Investigators* Background and Purpose-Genetic factors influence risk for ischemic stroke and likely do so at multiple steps in the pathogenic process. Variants in genes related to inflammation contribute to risk of stroke. The purpose of this study was to confirm our earlier finding of an association between allele 2 of a variable number tandem repeat of the IL-1 receptor antagonist gene (IL1RN) and cerebrovascular disease. Methods-An association study of the variable number tandem repeat genotype with ischemic stroke and stroke subtypes was performed on samples from a North American study of affected sibling pairs concordant for ischemic stroke and 2 North American cohorts of prospectively ascertained ischemic stroke cases and unrelated controls. DNA analysis was performed on cases and controls, stratified by race. Results-After adjustment for age, sex, and stroke risk factors, the odds ratio for association of allele 2 and ischemic stroke was 2.80 (95% confidence interval, 1.29 to 6.11; Pϭ0.03) for the white participants. The effect of allele 2 of IL1RN on stroke risk most closely fits a recessive genetic model (Pϭ0.009). For the smaller sample of nonwhite participants, the results were not significant. Conclusions-Allele 2 of IL1RN, present in nearly one-quarter of stroke patients, may contribute to genetic risk for ischemic stroke and confirm the previously identified association with cerebrovascular disease. These results are driven by the association in the white participants. Further exploration in a larger nonwhite sample is warranted.

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Interleukin-1 gene cluster polymorphisms in cerebral infarction

Cited by 22 publications

References 43 publications

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

Heritability ofIL-1AGene Promoter Polymorphism in Patients With Coronary Artery Disease: A Trio-Family Study

IL1RN VNTR Polymorphism in Ischemic Stroke

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