Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children: A cross-sectional study in Taiwan

Chang, Jung Su; Li, Yu Ling; Lu, Chiou Han; Owaga, Eddy; Chen, Wei Yu; Chiou, Hung Yi

doi:10.1016/j.nut.2014.02.021

Cited by 23 publications

(31 citation statements)

References 23 publications

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“…After applying the inclusion and exclusion criteria, a total of 26 original studies were ultimately included in the meta‐analysis (Fig. ), including 21 cross‐sectional studies and 5 case–control studies ; no cohort studies were include in the analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies reported serum iron levels , 10 reported TS% , 15 reported serum ferritin and 4 reported sTfR . Fifteen studies evaluated the risk of developing ID among overweight/obese populations , and four studies evaluated the risk of developing IDA . Detailed information regarding the weight diagnoses and outcomes is summarized in Supporting Information http://onlinelibrary.wiley.com/doi/10.1111/obr.12323/suppinfo.…”

Section: Resultsmentioning

confidence: 99%

“…After applying the inclusion and exclusion criteria, a total of 26 original studies were ultimately included in the meta-analysis ( Fig. 1), including 21 cross-sectional studies (2,3,5,6,(10)(11)(12)(13)(14)(15)22,(29)(30)(31)(32)(33)(34)(35)(36)(37)(38) and 5 case-control studies (39)(40)(41)(42)(43); no cohort studies were include in the analysis. Table 1 summarizes the characteristics of the 26 studies included in our analysis.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…However, the latest research suggests that obesity-associated low-grade inflammation and the iron-regulatory protein hepcidin play a principal role in the regulation of endogenous iron homeostasis (5)(6)(7)(8)(9). An increased risk of developing ID has been reported in obese adults and children (3,(10)(11)(12)(13); however, other studies suggested that ID and obesity may not be correlated (14,15). Thus, whether obesity affects the risk of developing ID remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Obesity and iron deficiency: a quantitative meta‐analysis

et al. 2015

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Hypoferraemia (i.e. iron deficiency) was initially reported among obese individuals several decades ago; however, whether obesity and iron deficiency are correlated remains unclear. Here, we evaluated the putative association between obesity and iron deficiency by assessing the concentration of haematological iron markers and the risks associated with iron deficiency in both obese (including overweight) subjects and non-overweight participants. We performed a systematic search in the databases PubMed and Embase for relevant research articles published through December 2014. A total of 26 cross-sectional and case-control studies were analysed, comprising 13,393 overweight/obese individuals and 26,621 non-overweight participants. Weighted or standardized mean differences of blood iron markers and odds ratio (OR) of iron deficiency were compared between the overweight/obese participants and the non-overweight participants using a random-effects model. Compared with the non-overweight participants, the overweight/obese participants had lower serum iron concentrations (weighted mean difference [WMD]: -8.37 μg dL(-1) ; 95% confidence interval [CI]: -11.38 to -5.36 μg dL(-1) ) and lower transferrin saturation percentages (WMD: 2.34%, 95% CI: -3.29% to -1.40%). Consistent with this finding, the overweight/obese participants had a significantly increased risk of iron deficiency (OR: 1.31; 95% CI: 1.01-1.68). Moreover, subgroup analyses revealed that the method used to diagnose iron deficiency can have a critical effect on the results of the association test; specifically, we found a significant correlation between iron deficiency and obesity in studies without a ferritin-based diagnosis, but not in studies that used a ferritin-based diagnosis. Based upon these findings, we concluded that obesity is significantly associated with iron deficiency, and we recommend early monitoring and treatment of iron deficiency in overweight and obese individuals. Future longitudinal studies will help to test whether causal relationship exists between obesity and iron deficiency.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Obesity and iron deficiency: a quantitative meta‐analysis

et al. 2015

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“…reactions even in such early potential celiac disease which could possibly affect iron metabolism (36). This could also explain the changes observed in sensitive iron parameters, especially the significantly lower ferritin values in potential celiac disease group compared with the controls (37).…”

Section: Borrelli and Colleagues (35) Recently Demonstrated Activatiomentioning

confidence: 97%

Anemia and Iron Deficiency in Children With Potential Celiac Disease

Repo

Lindfors

Mäki

et al. 2017

J. pediatr. gastroenterol. nutr.

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contributed the conception and design of the work and revised the text for important intellectual content. All authors approved the final version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. AbstractObjectives: Active screening for celiac disease frequently detects seropositive children with normal villous morphology (potential celiac disease). It remains unclear whether these subjects should be treated. We here investigated the prevalence of anemia and iron deficiency in children with potential and mucosal atrophy celiac disease.Methods: The prospective study involved 19 children with potential disease, 67 with partial or subtotal villous atrophy (P/SVA) and 16 with total villous atrophy (TVA). Twenty-three healthy children comprised the control group. The groups were compared for various clinical, histological and laboratory parameters and hepcidin.Results: The prevalence of abnormal parameters was as follows (controls, potential celiac disease, P/SVA and TVA, respectively): anemia 0%, 15%, 22% and 63%; low iron 5%, 0%, 14% and 50%; increased transferrin receptor 1 (TfR1) 5%, 16%, 20% and 47%; low ferritin 0%, 21%, 35% and 87%; and low transferrin saturation 10%, 11%, 41% and 71%. One subject had low folate and none had low vitamin B12. The median values for hemoglobin, total iron, ferritin and transferrin saturation were significantly lower and TfR1 values higher in TVA group compared with other groups. After a median of seven months on a gluten-free diet hemoglobin, total iron, ferritin and albumin in children with P/SVA exceeded the baseline values in the potential celiac disease group.Conclusions: The development of anemia and iron deficiency in celiac disease is a continuum and may already be present in children with normal villous morphology, advocating an early diagnosis and possible dietary treatment of these patients.

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