Interleukin 10 gene promoter polymorphism and risk of diffuse large B cell lymphoma (DLBCL)

Talaat, Roba M.; Abdel-Aziz, Amal; El-maadawy, Eman A.; Abdel-Bary, Naser

doi:10.1016/j.ejmhg.2013.09.001

Cited by 8 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-10-1082A/G variant genotypes (AG and GG) were not associated with susceptibility to either indolent or aggressive B-NHL subtypes. Similar results were reported by Talaat et al [ 21 ], who concluded that IL-10-1082A/G polymorphic genotypes could not be considered as a genetic risk factor for DLBCL in Egyptians. Moreover, the studies of Kube et al [ 22 ] and Berglund et al [ 23 ] revealed that the IL-10-1082A/G SNP was not associated with susceptibility to aggressive B-NHL in German or Swedish populations, respectively.…”

Section: Discussionsupporting

confidence: 89%

Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians

Rahman

Khorshied

Khorshid

et al. 2018

Tjh

View full text Add to dashboard Cite

Objective:Polymorphisms in the interleukin (IL)-2 and IL-10 genes are known to be associated with susceptibility to different immune-dysregulated disorders and cancers such as non-Hodgkin lymphoma (NHL). To explore the possible association between IL-2-330T/G and IL-10-1082A/G single-nucleotide polymorphisms and the susceptibility to B-cell NHL (B-NHL) in Egyptians, we conducted a case-control study.Materials and Methods:Genotyping of the studied genetic variations was done for 100 B-NHL patients as well as 100 age- and sex-matched healthy controls.Results:The IL-2 variant allele occurred at a significantly higher rate in patients than controls and was associated with susceptibility to B-NHL [odds ratio (OR): 1.91, 95% confidence interval (CI): 1.28-2.85]. It was also associated with advanced performance status score. IL-2 polymorphism conferred an almost threefold increased risk of diffuse large B-cell lymphoma (OR: 2.64, 95% CI: 1.35-5.15) and a fourfold increased risk of indolent subtypes (OR: 4.34, 95% CI: 1.20-15.7). The distribution of IL-10-1082A/G genotypes in our patients was close to that of the controls. Co-inheritance of the variant genotypes of IL-2 and the common genotype of IL-10 conferred an almost sixfold increased risk (OR: 5.75, 95% CI: 1.39-23.72), while co-inheritance of the variant genotypes of IL-2 and IL-10 conferred fivefold increased risk of B-NHL (OR: 5.43, 95% CI: 1.44-20.45). The variant genotypes of IL-2-330T/G and IL-10-1082A/G had no effect on the disease-free survival of B-NHL patients.Conclusion:The present study highlights the possible involvement of the IL-2-330T/G genetic polymorphism in the susceptibility to B-NHL in Egypt, especially indolent subtypes. Moreover, IL-10-1082A/G is not a molecular susceptibility marker for B-NHL in Egyptians.

show abstract

Section: Discussionsupporting

confidence: 89%

Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians

Rahman

Khorshied

Khorshid

et al. 2018

Tjh

View full text Add to dashboard Cite

show abstract

“…6 Viral IL10 is critical for B-cell transformation and proliferation by EBV. 42,43 High IL10 levels were found in the sera of NHL patients [44][45][46][47] and were associated with poor prognosis. 44,45,[48][49][50][51] In Q fever, overproduction of IL10 by infected monocytes is critical in sustaining replication of the bacterium, and is associated with an inhibition of the microbicidal activity of macrophages.…”

Section: Discussionmentioning

confidence: 99%

B-cell non-Hodgkin lymphoma linked to Coxiella burnetii

Melenotte

Million

Audoly

et al. 2016

Blood

View full text Add to dashboard Cite

Key Points• Coxiella burnetii is associated with an increased risk of lymphoma; its presence in the tumor microenvironment may favor lymphomagenesis.• Lymphoma has to be considered in patients with Q fever and lymphoid disorders, especially those with persistent focalized infections.Bacteria can induce human lymphomas, whereas lymphoproliferative disorders have been described in patients with Q fever. We observed a lymphoma in a patient with Q fever that prompted us to investigate the association between the 2 diseases. We screened 1468 consecutive patients of the 2004 to 2014 French National Referral Center for Q fever database. The standardized incidence ratios (SIRs) of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) were calculated comparatively to the 2012 Francim Registry. The presence of Coxiella burnetii was tested using immunofluorescence and fluorescence in situ hybridization using a specific 16S ribosomal RNA probe and genomic DNA probe. Seven patients (0.48%) presented mature B-cell lymphoma consisting of 6 DLBCL and 1 FL. An excess risk of DLBCL and FL was found in Q fever patients compared with the general population (SIR [95% confidence interval], 25.4 [11.4-56.4] and 6.7 [0.9-47.9], respectively). C burnetii was detected in CD68 1 macrophages within both lymphoma and lymphadenitis tissues but localization in CD123 1 plasmacytoid dendritic cells (pDCs) was found only in lymphoma tissues. Q fever patients with persistent focalized infection were found more at risk of lymphoma (hazard ratio, 9.35 [1.10-79.4]). Interleukin-10 (IL10) overproduction (P 5 .0003) was found in patients developing lymphoma. These results suggest that C burnetii should be added to the list of bacteria that promote human B-cell non-Hodgkin lymphoma, possibly by the infection of pDCs and IL10 overproduction. Screening for early lymphoma diagnosis should be considered in the management of patients with Q fever, especially those with persistent focalized infections. (Blood. 2016;127(1):113-121)

show abstract

“…Suspensions were analyzed in a FACSCalibur and differences between frequencies of the T reg population evaluated by t-test (PϽ0.05). In fact, IL-10 promoter polymorphism Ϫ819C/T, which leads to higher IL-10 expression [45], represents an increased risk to cervical cancer development [46]. Mice were observed every 3 days for tumor detection until tumors, from any group, reached 1-1.2-mm diameter in one axis.…”

Section: Discussionmentioning

confidence: 99%

“…Again, we show that IL-10 is a key molecule in the orchestration of host tolerance toward tumor antigens. In fact, IL-10 promoter polymorphism Ϫ819C/T, which leads to higher IL-10 expression [45], represents an increased risk to cervical cancer development [46]. Concerning cervical cancer, most research groups obtained results that indicate that IL-10 plays a role in suppression of anti-HPV responses, therefore, facilitating tumor growth [47].…”

Section: Discussionmentioning

confidence: 99%

HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells

Stone

Rossetti

Bolpetti

et al. 2014

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Tumors are complex structures containing different types of cells and molecules. The importance of the tumor microenvironment in tumor progression, growth, and maintenance is well-established. However, tumor effects are not restricted to the tumor microenvironment. Molecules secreted by, as well as cells that migrate from tumors, may circulate and reach other tissues. This may cause a series of systemic effects, including modulation of immune responses, and in some cases, leukocytosis and metastasis promotion. Leukocytosis has been described as a poor prognostic factor in patients with cervical cancer. The main etiological factor for cervical cancer development is persistent infection with high oncogenic risk HPV. Our laboratory has been exploring the effects of high oncogenic risk, HPV-associated tumors on lymphoid organs of the host. In the present study, we observed an increase in myeloid cell proliferation and alteration in cell signaling in APCs in the spleen of tumor-bearing mice. In parallel, we characterized the cytokines secreted in the inflammatory and tumor cell compartments in the tumor microenvironment and in the spleen of tumor-bearing mice. We show evidence of constitutive activation of the IL-6/STAT3 signaling pathway in the tumor, including TAMs, and in APCs in the spleen. We also observed that IL-10 is a central molecule in the tolerance toward tumor antigens through control of NF-κB activation, costimulatory molecule expression, and T cell proliferation. These systemic effects over myeloid cells are robust and likely an important problem to be addressed when considering strategies to improve anti-tumor T cell responses.

show abstract

Interleukin 10 gene promoter polymorphism and risk of diffuse large B cell lymphoma (DLBCL)

Cited by 8 publications

References 30 publications

Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians

Association of Interleukin-2-330T/G and Interleukin-10-1082A/G Genetic Polymorphisms with B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians

B-cell non-Hodgkin lymphoma linked to Coxiella burnetii

HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells

Contact Info

Product

Resources

About