Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases

Zhang, Qian; Chen, Bin; Yan, Fuhua; Guo, Jianbin; Zhu, Xiaofeng; Ma, Shouzhi; Yang, Wenrong

doi:10.1155/2014/284836

Cited by 146 publications

(137 citation statements)

References 64 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…At week 12, the IML group released significantly more IL‐10 (+45.74%) than the CL group suggesting the need to inhibit the more active remodeling process in the IML group. This suggests the anti‐inflammatory action of IL‐10 and its action as a suppressor in the osteoclastic differentiation, finalizing the bone resorption process . The positive correlation between IL‐10 and TNF‐α and IL‐1β biomarkers in both groups at week 8 evidences the inhibiting role of IL‐10 in the final phase of osseointegration, reducing the pro‐inflammatory response of the other cytokines …”

Section: Discussionmentioning

confidence: 77%

Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial

Bielemann

Marcello-Machado

Schuster

et al. 2018

J of Periodontal Research

View full text Add to dashboard Cite

Background Biological responses to different loading protocols during the bone healing phase in subjects with long time since edentulism, rehabilitated with narrow diameter implants (NDIs) to retain mandibular overdentures (MOs), are still unavailable. Objective This randomized clinical trial compared the peri‐implant health, implant stability, and concentrations of pro‐ and anti‐inflammatory cytokines in the peri‐implant crevicular fluid (PICF) in mandibular edentulous patients under conventional (CL) and immediate loading (IML) during healing. Methodology Twenty totally edentulous patients received two NDIs (2.9 × 10 mm, Facility NeoPoros) placed in mandible anterior region and were randomly assigned to two loading protocols: CL (n = 10) and IML (n = 10). The following clinical outcomes were evaluated 1, 2, 4, 8, and 12 weeks after surgery: (a) peri‐implant tissue health (gingival index‐GI, plaque index‐PI, calculus‐presence CP, probing depth‐PD, and bleeding on probing‐BOP); (b) implant stability quotient (ISQ); and (c) IL‐1β, IL‐6, IL‐10, and TNF‐α levels in the PICF analyzed by ELISA. Results The CL group showed significantly higher CP scores at weeks 8 and 12. The IML group showed significantly higher GI from the first week onwards. The IML group presented significantly lower PD at all follow‐up times, and higher BOP rates than CL at week 12. The ISQ values of the CL group were higher than those of the IML group, except at week 4. The IML group released significantly more TNF‐α between weeks 1 and 4 and more IL‐1β during week 4‐12, while releasing less IL‐6 until week 8, mainly at week 2 (−47.6%). The release of IL‐10 was similar for both groups and increased progressively over time. At week 12, the IML group released 45.74% more IL‐10 than the CL group. The survival rates were 95% and 90% for CL and IML, respectively. Conclusion The IML group presented more favorable PD at all evaluation times; the differences between the other clinical parameters were less systematic. The implant stability and the inflammatory marker concentrations were more stable in the CL group.

show abstract

Section: Discussionmentioning

confidence: 77%

Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial

Bielemann

Marcello-Machado

Schuster

et al. 2018

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

“…Studies have demonstrated that IL-10 is a potent anti-inflammatory cytokine [25, 26]. IL-10 can maintain bone mass through inhibiting osteoclastic bone resorption and enhancing osteoblastic bone formation.…”

Section: Discussionmentioning

confidence: 99%

miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6

Jiang

Deng

et al. 2018

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

It has been suggested that microRNAs (miRs) are involved in the immune regulation of periodontitis. However, it is unclear whether and how miRs regulate the function of B cells in the context of periodontitis. This study is to explore the role of miR-146a on the inflammatory cytokine production of B cells challenged by Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS). Primary B cells were harvested from mouse spleen. Quantitative real-time polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA) were used to detect the expression of inflammatory cytokines in B cells in the presence or absence of P. gingivalis LPS and/or miR-146a. Bioinformatics, luciferase reporter assay and overexpression assay were used to explore the binding target of miR-146a. Our results showed that miR-146a level in B cells was elevated by P. gingivalis LPS stimulation, and the mRNA expressions of interleukin (IL)-1β, 6 and 10, and IL-1 receptor associated kinase-1 (IRAK1), but not TNF receptor associated factor 6 (TRAF6), were also upregulated. The expression levels of IL-1β, 6, 10 and IRAK1 were reduced in the presence of miR-146a mimic, but were elevated by the addition of miR-146a inhibitor. MiR-146a could bind with IRAK1 3' untranslated region (UTR) but not TRAF6 3'-UTR. Overexpression of IRAK1 reversed the inhibitory effects of miR-146a on IL-1β, 6 and 10. In summary, miR-146a inhibits inflammatory cytokine production in B cells through directly targeting IRAK1, suggesting a regulatory role of miR-146a in B cell-mediated periodontal inflammation.

show abstract

“…Current data reveal that IL‐10 is upregulated in SIM‐treated rat molar periodontal tissues. IL‐10 is a potent anti‐inflammatory cytokine that also inhibits osteoclastic bone resorption and regulates osteoblastic bone formation . Subgingivally delivered SIM in humans has been shown to stimulate IL‐10 in the fluid around periodontitis pockets and to improve periodontal attachment .…”

Section: Discussionmentioning

confidence: 99%

Identification of Genes Differentially Expressed in Simvastatin‐Induced Alveolar Bone Formation

et al. 2019

View full text Add to dashboard Cite

Local delivery of simvastatin (SIM) has exhibited potential in preventing inflammation and limiting bone loss associated with experimental periodontitis. The primary aim of this study was to analyze transcriptome changes that may contribute to SIM's reduction of periodontal inflammation and bone loss. We evaluate the global genetic profile and signaling mechanisms induced by SIM on experimental periodontitis bone loss and inflammation. Twenty mature female Sprague Dawley rats were subjected to ligature‐induced experimental periodontitis around maxillary second molars (M2) either unilaterally (one side untreated, n = 10) or bilaterally (n = 10). After the ligature removal at day 7, sites were injected with either carrier, pyrophosphate (PPi ×3), 1.5‐mg SIM‐dose equivalent SIM‐pyrophosphate prodrug, or no injection. Three days after ligature removal, animals were euthanized; the M1‐M2 interproximal was evaluated with μCT, histology, and protein expression. M2 palatal gingiva was harvested for RNA sequencing. Although ligature alone caused upregulation of proinflammatory and bone catabolic genes and proteins, seen in human periodontitis, SIM‐PPi upregulated anti‐inflammatory (IL‐10, IL‐1 receptor‐like 1) and bone anabolic (insulin‐like growth factor, osteocrin, fibroblast growth factor, and Wnt/ β‐catenin) genes. The PPi carrier alone did not have these effects. Genetic profile and signaling mechanism data may help identify enhanced pharmacotherapeutic approaches to limit or regenerate periodontitis bone loss. © 2018 The Authors. JBMR Plus Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.

show abstract

Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases

Cited by 146 publications

References 64 publications

Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial

Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial

miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6

Identification of Genes Differentially Expressed in Simvastatin‐Induced Alveolar Bone Formation

Contact Info

Product

Resources

About