1996
DOI: 10.1016/s0039-6060(96)80299-6
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Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice

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Cited by 158 publications
(77 citation statements)
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“…The changes of IL-6 can reflect the degree of surgical stimulation and injury, [20] whereas IL-10 can inhibit the release of inflammatory cytokines IL-6 and tumor necrosis factor (TNF)-a, which play an anti-inflammatory role. [21] As a marker protein of glial cells, S100b protein is mainly expressed in astrocytes and Schwann cells. [22] High concentration of S100b protein is toxic to neurons, and is closely related to POCD.…”
Section: Discussionmentioning
confidence: 99%
“…The changes of IL-6 can reflect the degree of surgical stimulation and injury, [20] whereas IL-10 can inhibit the release of inflammatory cytokines IL-6 and tumor necrosis factor (TNF)-a, which play an anti-inflammatory role. [21] As a marker protein of glial cells, S100b protein is mainly expressed in astrocytes and Schwann cells. [22] High concentration of S100b protein is toxic to neurons, and is closely related to POCD.…”
Section: Discussionmentioning
confidence: 99%
“…in vivo [22,29] , the effect of PPARγ on AP has not been fully elucidated. This anti-inflammatory effect seems to be related to multiple mechanisms.…”
mentioning
confidence: 99%
“…The onset and subsequent rapid deterioration seen in SAP is likely due to the over-production of proinflammatory cytokines, which are considered critical to the pathogenesis of the disease [14] . Thus, cytokines derived from macrophages are believed to play an integral role in the evolution of acute pancreatitis [22] . It has been suggested that the local pancreatic lesion activates macrophages to release pro-inflammatory cytokines [14,23] .…”
Section: Discussionmentioning
confidence: 99%