Interleukin‐10 promoter polymorphisms in hepatitis C patients with and without <i>Schistosoma mansoni</i> co‐infection

Abbas, Omaima M; Abdel‐Rahman, Mohamed H.; Omar, Nabil; Badran, Hanaa M.; Amir, Elamir M.

doi:10.1111/j.1478-3231.2009.02068.x

Cited by 19 publications

(9 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we did not observe any association between IL-10 polymorphisms with S. haematobium and P. falciparum co-infections in this study. This is in agreement with previous findings indicating that these three IL-10 promoter variants are not associated with susceptibility to hepatitis C virus infection with and without S. mansoni co-infection [33].…”

Section: Discussionsupporting

confidence: 93%

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Adedoja

Hoàn

Tong

et al. 2017

Tropical Med Int Health

View full text Add to dashboard Cite

Abstractobjective Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by Th1 cells and macrophages. The rationale of this study was to examine and validate possible contributions of IL-10 promoter polymorphisms in sub-Saharan Africa in children infected with either Plasmodium falciparum or Schistosoma haematobium and in children co-infected with both parasites.materials and methods A total of 309 Nigerian children aged 4-15 years were recruited. The study group consisted of individuals infected either with P. falciparum (n = 76) or S. haematobium (n = 94) in mono-infections, a group of children co-infected with both P. falciparum and S. haematobium (n = 62) and matched healthy controls (n = 77). The IL-10 promoter polymorphisms -1082G/A, -819C/T and -592C/A were genotyped by direct sequencing.results The frequencies of the IL-10 -1082GG genotype, the -1082G allele and haplotype GCC (positions -1082, -819 and -592) were higher in children infected with P. falciparum than in healthy controls, indicating that the -1082GG genotype and the -1082G allele and the GCC haplotype are associated with increased susceptibility to malaria infection (OR = 3.4, 95% CI = 1.2-10.8, P = 0.02; OR = 2.5, 95% CI = 1.1-3.4, P = 0.02; OR = 3.8, 95% CI = 2.0-7.2, P = 0.0001, respectively). Children with the -1082GG genotype had a higher parasitaemia than children with the -1082AA or -1082AG genotypes (P = 0.0017). Haplotype GCC occurred more frequently in children infected with S. haematobium, while haplotype GTA was less frequent than in controls (OR = 2.2, 95% CI = 1.2-4.4, P = 0.017 and OR = 0.1, 95% CI = 0.02-0.5, P = 0.0004, respectively). No differences in the frequencies of IL-10 promoter polymorphisms were observed between children with P. falciparum-S. haematobium co-infections and healthy controls.conclusion Although IL-10 promoter polymorphisms are not associated with P. falciparum and S. haematobium co-infection, variant -1082G/A and haplotype GCC are associated with malaria, whereas the IL-10 haplotypes GCC and GTA are associated with schistosomiasis.

show abstract

Section: Discussionsupporting

confidence: 93%

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Adedoja

Hoàn

Tong

et al. 2017

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…The details of the discrepancy in the results between IL-10 gene polymorphisms and IFN anti-viral response are still unknown. Abbas et al (37) suggested that the recent IFN treatment strategies including IFN modifications (recombinant and PEGlyated), the duration of treatment, and combination with ribavirin administration might affect the results of these studies. For example, ribavirin administration promotes Th1 lymphocytes and suppresses IL-10 production (38).…”

Section: Discussionmentioning

confidence: 99%

Functional Gene Polymorphisms of Interleukin-10 are Associated with Liver Disease Progression in Japanese Patients with Hepatitis C Virus Infection

et al. 2011

View full text Add to dashboard Cite

Objective The inter-individual difference in response to liver injury appears to be important in the progression of liver fibrosis. Interleukin 10 (IL-10) is an anti-inflammatory cytokine, and several functional gene polymorphisms have been found. The aim of this study was to examine the possible association of IL-10 polymorphisms with the progression of liver fibrosis in hepatitis C virus (HCV)-related chronic liver disease patients. Methods We examined the IL-10 -1087 A/G and -824 T/C gene polymorphisms in 184 Japanese patients with HCV-related chronic liver disease: 94 chronic hepatitis (CH) and 90 with liver cirrhosis (LC). Results There were no significant differences in the genotype distributions or allele frequencies of IL-10 -824 T/C and -1087 A/G between the CH and LC groups. However, among the cirrhotic patients, the lower transcriptional allele, -824 T homozygotes had significantly lower serum albumin and platelet counts, and a higher Child-Pugh score than the -824 C carriers, and the lower transcriptional allele, -1087 A homozygotes had a higher ICG-R 15 compared with -1087 G carriers. Haplotype analysis of IL-10 -1087/-824 showed no significant difference between the CH and LC groups, but the combinations of AT and AC haplotypes (AT/ AT, AT/AC and AC/AC) had a significantly higher ICG-R 15 than the GC carriers. Conclusion IL-10 lower transcriptional -824 T allele, -1087 A allele, and -1087/-824 haplotypes AT and AC are risk factors for the progression of liver fibrosis in HCV-related chronic liver disease.

show abstract

“…[2] of a high response among Egyptian patients with schistosomiasis despite the presence of more severe fibrosis. Increased susceptibility to HCV in schistosomiasis patients because of increased production of IL‐10 is no longer accepted [21]. The reported normal thrombopoietin [22] and elevated von Willebrand factor antigen [23] levels in schistosomiasis may explain the absence of thrombocytopenia as an adverse effect in our patients with bilharzial coinfection.…”

Section: Discussionmentioning

confidence: 90%

Hepatitis C virus genotype 4 with normal transaminases: histological changes, schistosomiasis and response to treatment

Derbala

Amer

Almohanadi³

et al. 2010

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Introduction and aims-Among individuals with chronic HCV infection, approximately 30% of patients show persistently normal alanine aminotransferase (PNALT). Individuals with PNALT have been historically excluded from antiviral treatment. However, some studies have reported sudden worsening of disease in patients with PNALT, suggesting the need to treat individuals with PNALT. To evaluate this further, we compared fibrosis severity and response to treatment in patients with PNALT to patients with abnormal ALT. In addition, we investigated whether liver histology and schistosomiasis affect response to treatment differently in those with PNALT and abnormal ALT.

show abstract

Interleukin‐10 promoter polymorphisms in hepatitis C patients with and without Schistosoma mansoni co‐infection

Abstract: Our findings suggest that common IL-10 (-1082, -819 and -592) genotypes/haplotypes do not influence the degree of HAI and response to combination therapy or susceptibility to HCV infection with and without S. mansoni co-infection.

Cited by 19 publications

References 66 publications

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Differential contribution of interleukin‐10 promoter variants in malaria and schistosomiasis mono‐ and co‐infections among Nigerian children

Functional Gene Polymorphisms of Interleukin-10 are Associated with Liver Disease Progression in Japanese Patients with Hepatitis C Virus Infection

Hepatitis C virus genotype 4 with normal transaminases: histological changes, schistosomiasis and response to treatment

Contact Info

Product

Resources

About