Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner

Tedde, Andrea; Putignano, Anna Laura; Bagnoli, Siro; Congregati, Caterina; Milla, Mónica; Sorbi, Sandro; Genuardi, Maurizio; Papi, Laura

doi:10.1080/00365520701885507

Cited by 51 publications

(24 citation statements)

References 25 publications

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“…In subsequent studies, IL10 promoter polymorphisms were sporadically associated with IBD. For example, G-1082A SNPs was associated with UC and/or CD in Spanish, Australian, New Zealand, Italian, and Mexican studies (Fernandez et al 2005;Fowler et al 2005;Castro-Santos et al 2006;Hong et al 2008;Tedde et al 2008;Garza-Gonzalez et al 2010;Wang et al 2011), but the findings were not consistent, showing associations for both G and A allele (or genotypes containing those alleles). The polymorphism C-592A was also associated with CD in Canadian pediatric patients (Amre et al 2009).…”

Section: Discussionmentioning

confidence: 94%

The Polymorphism rs3024505 (C/T) Downstream of the <i>IL10 </i>Gene Is Associated with Crohn’s Disease in Serbian Patients with Inflammatory Bowel Disease

Mijač

Petrović

Djuranović

et al. 2016

Tohoku J. Exp. Med.

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Inflammatory bowel disease (IBD), manifesting as Crohn's disease (CD) and ulcerative colitis (UC), is characterized by recurring episodes of inflammation in gastrointestinal tract, in which aberrant production of regulatory cytokine interleukin-10 (IL-10) presumably plays important role. Single nucleotide polymorphisms (SNPs) that affect IL-10 production, such as rs1800896 (G/A) at position -1082 and rs1800871 (C/T) at position -819 in the promoter region of the IL10 gene, have been associated with CD and/or UC, but the results were inconsistent. Another SNP that may alter IL-10 production, rs3024505 (C/ T) located immediately downstream of the IL10 gene has been recently identified. T allele of rs3024505 was associated with both UC and CD in Western populations, but the studies from East European countries are lacking. Therefore, our aim was to assess the association of rs3024505, rs1800896 and rs1800871 with Serbian IBD patients. To this end, 107 CD and 99 UC patients and 255 healthy controls were genotyped. As a result, T allele of rs3024505 was associated with CD at allelic, genotypic (GT genotype) and haplotypic (GCCT haplotype) level, suggesting potential role of this variant in susceptibility to CD. In contrast, CD patients carrying C allele of rs3024505 had significantly increased risk of anemia and stricturing/penetrating behavior. No association was observed between rs3024505 and UC or SNPs in IL10 promoter region and any form of IBD. In conclusion, rs3024505 SNP flanking the IL10 gene is associated with susceptibility and severity of disease in Serbian CD patients, further validating its role as a potential biomarker in IBD.

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Section: Discussionmentioning

confidence: 94%

The Polymorphism rs3024505 (C/T) Downstream of the <i>IL10 </i>Gene Is Associated with Crohn’s Disease in Serbian Patients with Inflammatory Bowel Disease

Mijač

Petrović

Djuranović

et al. 2016

Tohoku J. Exp. Med.

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“…On the other hand, IL-10-1082 G/A polymorphism has been reported to influence susceptibility to UC [38,86,126]. A gender effect has been reported, with women of AG/AA genotypes of IL-10-1082 G/A, having a higher risk of developing UC at a younger age and is related to the lower IL-10 production associated with the -1082A allele and to the IL10 downregulating effect of estrogens [86].…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the IL-10 promoter polymorphisms and IBD susceptibility have also been inconsistent [71,[83][84][85][86][87][88][89]. Some studies have found an associations between IL-10 polymorphism and IBD [71,86,87,90], whereas other studies were unable to find any association between IBD and the IL-10 promoter polymorphisms [83,84,88,91].…”

Section: Introductionmentioning

confidence: 91%

“…Some studies have found an associations between IL-10 polymorphism and IBD [71,86,87,90], whereas other studies were unable to find any association between IBD and the IL-10 promoter polymorphisms [83,84,88,91]. In this study, we evaluated the association of five polymorphism in IL-10, TNF-α, and TNF-β genes with susceptibility risk of IBD in Saudi patients.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Bowel Disease: The Association of Inflammatory Cytokine Gene Polymorphisms

Al-Robayan¹,

Arfin²,

Meghaiseeb³

et al. 2016

New Insights Into Inflammatory Bowel Disease

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“…Finally, a total of 7 case-control studies met the preset inclusion criteria, in which 1890 cases and 2929 controls were included for the pooled analysis [15][16][17][18][19][20][21] . The characteristics of the studies are summarized in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: A meta-analysis

Guo

et al. 2016

Afr H. Sci.

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Background: The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD) ,but the previous results are conflicting. Materials and methods: The present study aimed at investigating the association between this polymorphism and risk of IBD using a meta-analysis.PubMed,Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effects models. Results: A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64-1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn's disease(CD)(CT vs. CC:OR=0.68,95%CI 0.48-0.97). Conclusion: In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk.

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Interleukin-10 promoter polymorphisms influence susceptibility to ulcerative colitis in a gender-specific manner

Cited by 51 publications

References 25 publications

The Polymorphism rs3024505 (C/T) Downstream of the <i>IL10 </i>Gene Is Associated with Crohn’s Disease in Serbian Patients with Inflammatory Bowel Disease

The Polymorphism rs3024505 (C/T) Downstream of the <i>IL10 </i>Gene Is Associated with Crohn’s Disease in Serbian Patients with Inflammatory Bowel Disease

Inflammatory Bowel Disease: The Association of Inflammatory Cytokine Gene Polymorphisms

Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: A meta-analysis

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