Interleukin 13 and Interleukin 4 Receptor-α Polymorphisms in Rhinitis and Asthma

Abstract

Background: Asthma and rhinitis may represent two manifestations of the same airway disease. Genetic research can increase our understanding of their common or distinct pathogenesis. IL13 and IL4R polymorphisms are associated with asthma and show gene-gene interaction in asthma. Their role in rhinitis has not been extensively studied. Methods: Association of IL13 and IL4R polymorphisms in relation to rhinitis, asthma, serum IgE and skin test response was studied in: (1) 188 trios ascertained through a proband with rhinitis who were clinically not affected by asthma; (2) 407 trios with an asthmatic proband, and (3) 118 asthma cases and 102 unrelated healthy controls using family-based association testing, logistic regression, and analysis of variance as appropriate. Gene-gene interaction was evaluated using logistic regression analysis. Results: IL13 C–1111T (rs1800925) was significantly associated with rhinitis and atopic phenotypes in rhinitis trios that were not affected by clinical asthma. IL13 Arg130Gln (rs20541) and G870A (rs1295685) were consistently associated with asthma and serum IgE in both asthma populations. IL4R Glu375Ala (rs1805011) and Ser411Leu (rs1805013) were associated with asthma in the asthma case-control population. Combining risk genotypes of IL13 Arg130Gln with IL4R Glu375Ala, and IL13 C–1111T with IL4R Ser478Pro yielded increased risks for asthma compared to their separate effects. Conclusion:IL13 polymorphisms were associated with asthma and rhinitis without clinical asthma; thus, these polymorphisms may constitute a common etiologic pathway for their development. In addition, the study replicates a previously reported interaction of IL13 and IL4R polymorphisms in asthma.

Multiple Hypersensitivities Including Recurrent Airway Obstruction, Insect Bite Hypersensitivity, and Urticaria in 2 Warmblood Horse Populations

“…Furthermore, the combined occurrence of allergic dermatitis, conjunctivitis, rhinitis, and asthma‐like clinical signs has been reported both in naturally occurring and experimental hypersensitivities in dogs 8. The occurrence of MHS, such as asthma, rhinitis, and allergic skin diseases, in the same individual also has been described in humans 9, 10, 11, 12. A temporal sequence of hypersensitivities has been termed an “allergic march” with childhood atopic dermatitis being the precursor to allergic rhinitis and asthma years later 12…”

“…For instance, interleukin‐4 receptor α‐chain ( IL4RA ) has been identified as a candidate gene in atopic dermatitis, rhinitis, and asthma. In addition, IL4RA has been linked to an “allergic predisposition” and is associated with increased serum immunoglobulin E (IgE) concentrations in asthma‐affected humans 9, 10, 11. Polymorphisms in IL13 , a gene involved in the same T‐helper‐2 (Th2)‐type response as IL4RA , are associated with both rhinitis and asthma, and rhinitis was shown to be a risk factor for the development of asthma 10.…”

Interleukin-13 as an important cytokine: A review on its roles in some human diseases

“…This role has been supported by showing that IL-13 polymorphisms, such as G+2044A [e.g. 91,92], C-1112T [e.g. 93], and A-1512C [e.g.…”

H1 antihistamines in allergic rhinitis: The molecular pathways of interleukin and toll - like receptor systems

“…They showed that rs438421 polymorphism in IL-12Rβ1 gene had a significant association with AR. In addition, rs1800925 polymorphism in IL-13 gene showed a significant association with AR susceptibility in Netherland population (23). In other study conducted in Malaysian population, Yadav et al (32) investigated the polymorphic variants of IL-13 R130Q, IL-4 T589C, IL-4 RAI50V, and IL-4 RAQ576R genes in AR patients.…”

“…On contrary, rs2243248, rs2243250, and rs2070874 haplotypes of the IL-4 gene had a significant negative correlation with AR. In other study, Bottema et al (23) analyzed IL-13 and IL-4 polymorphisms in AR and asthma patients in the Netherland. They showed that IL-13 C-1111T (rs1800925) polymorphism was significantly associated with rhinitis and atopic phenotypes in AR patients, but was not associated with asthma.…”