Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome

Orsatti, Cláudio Lera; Orsatti, Fábio Lera; Bezerra, Thaiz Geovana; Quevedo, Ana; Nahás, Eliana Aguiar Petri

doi:10.1080/09513590.2022.2105832

Cited by 3 publications

(2 citation statements)

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“…In addition, it directly stimulates glucose uptake in muscle cells [ 224 , 225 ]. High levels of IL-15 contribute to the improvement of insulin resistance in postmenopausal women with metabolic syndrome [ 226 ]. IL-15 triggers autophagy in the immune cells, mediating homeostasis and the survival of these cells [ 227 , 228 ].…”

Section: Skeletal Muscle Tissuementioning

confidence: 99%

“…IL-15 triggers autophagy in the immune cells, mediating homeostasis and the survival of these cells [ 227 , 228 ]. IL-6 is a pleiotropic cytokine with respect to insulin resistance; while numerous studies have indicated its association with insulin resistance [ 226 – 229 ], others have reported its insulin-sensitizing effects [ 230 , 231 ]. It has been found that IL-6 inhibits starvation-stimulated autophagy in pro-monocytic U937 cells [ 184 ].…”

Section: Skeletal Muscle Tissuementioning

confidence: 99%

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Crosstalk between autophagy and insulin resistance: evidence from different tissues

Sadeghi,

Niknam,

Momeni-Moghaddam

et al. 2023

Eur J Med Res

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Insulin is a critical hormone that promotes energy storage in various tissues, as well as anabolic functions. Insulin resistance significantly reduces these responses, resulting in pathological conditions, such as obesity and type 2 diabetes mellitus (T2DM). The management of insulin resistance requires better knowledge of its pathophysiological mechanisms to prevent secondary complications, such as cardiovascular diseases (CVDs). Recent evidence regarding the etiological mechanisms behind insulin resistance emphasizes the role of energy imbalance and neurohormonal dysregulation, both of which are closely regulated by autophagy. Autophagy is a conserved process that maintains homeostasis in cells. Accordingly, autophagy abnormalities have been linked to a variety of metabolic disorders, including insulin resistance, T2DM, obesity, and CVDs. Thus, there may be a link between autophagy and insulin resistance. Therefore, the interaction between autophagy and insulin function will be examined in this review, particularly in insulin-responsive tissues, such as adipose tissue, liver, and skeletal muscle.

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